Search Results - "Gimisis, Thanasis"

Radical Reactions in Organic Synthesis: Exploring in-, on-, and with-Water Methods by Chatgilialoglu, Chryssostomos, Barata-Vallejo, Sebastian, Gimisis, Thanasis

“…Radical reactions in water or aqueous media are important for organic synthesis, realizing high-yielding processes under non-toxic and environmentally friendly…”
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Anomeric Spironucleosides of β-d-Glucopyranosyl Uracil as Potential Inhibitors of Glycogen Phosphorylase by Stathi, Aggeliki, Mamais, Michael, Chrysina, Evangelia D, Gimisis, Thanasis

“…In the case of type 2 diabetes, inhibitors of glycogen phosphorylase (GP) may prevent unwanted glycogenolysis under high glucose conditions and thus aim at the…”
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Synthesis, Kinetic and Conformational Studies of 2-Substituted-5-(β-d-glucopyranosyl)-pyrimidin-4-ones as Potential Inhibitors of Glycogen Phosphorylase by Mavreas, Konstantinos F, Neofytos, Dionysios D, Chrysina, Evangelia D, Venturini, Alessandro, Gimisis, Thanasis

“…Dysregulation of glycogen phosphorylase, an enzyme involved in glucose homeostasis, may lead to a number of pathological states such as type 2 diabetes and…”
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Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies by Wen, Xiaoan, Sun, Hongbin, Liu, Jun, Cheng, Keguang, Zhang, Pu, Zhang, Liying, Hao, Jia, Zhang, Luyong, Ni, Peizhou, Zographos, Spyros E, Leonidas, Demetres D, Alexacou, Kyra-Melinda, Gimisis, Thanasis, Hayes, Joseph M, Oikonomakos, Nikos G

“…Twenty-five naturally occurring pentacyclic triterpenes, 15 of which were synthesized in this study, were biologically evaluated as inhibitors of rabbit muscle…”
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Isolation, Characterization, and Independent Synthesis of Guanine Oxidation Products by Gimisis, Thanasis, Cismaş, Crina

“…Oxidatively produced DNA damage is a physiological process that has been associated with many human conditions. Of the four DNA bases, guanine is the most…”
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C-1′ Radical-Based Approaches for the Synthesis of Anomeric Spironucleosides by Chatgilialoglu, Chryssostomos, Gimisis, Thanasis, Spada, Gian Piero

“…A 1,5‐radical translocation from a conveniently situated alkoxyl or vinyl radical next to the C‐1′ position is the key step for the successful radical‐based…”
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DNA Damage and Radical Reactions: Mechanistic Aspects, Formation in Cells and Repair Studies by Jean Cadet, Thomas Carell, Luciano Cellai, Chryssostomos Chatgilialoglu, Thanasis Gimisis, Miguel Miranda, Peter O'Neill, Jean-Luc Ravanat, Marc Robert

“…Several examples of oxidative and reductive reactions of DNA components that lead to single and tandem modifications are discussed in this review. These…”
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Requirement of transcription-coupled nucleotide excision repair for the removal of a specific type of oxidatively induced DNA damage by Sarmini, Leen, Meabed, Mohammed, Emmanouil, Eirini, Atsaves, George, Robeska, Elena, Karwowski, Bolesław T, Campalans, Anna, Gimisis, Thanasis, Khobta, Andriy

“…Abstract Accumulation of DNA damage resulting from reactive oxygen species was proposed to cause neurological and degenerative disease in patients, deficient…”
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First characterisation of two important postulated intermediates in the formation of a HydT DNA lesion, a thymidine oxidation product by Psykarakis, Emmanuel E, Chatzopoulou, Elli, Gimisis, Thanasis

“…A number of environmental pollutants and endogenous oxidation agents form 1-(2-deoxy-β-d-ribofuranosyl)-5-hydroxy-5-methylhydantoin (HydT), an important DNA…”
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Synthesis and Biological Evaluation of Novel 1′-Branched and Spironucleoside Analogues by Chatgilialoglu, Chryssostomos, Ferreri, Carla, Gimisis †, Thanasis, Roberti, Marinella, Balzarini, Jan, De Clercq, Erik

“…Novel anomeric spironucleosides and 1′-cyano-2′,3′-didehydro-2′,3′-dideoxyuridine, a structural analogue of known anti-HIV agents, were prepared by…”
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A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function by Minadakis, Michail-Panagiotis, Mavreas, Konstantinos F, Neofytos, Dionysios D, Paschou, Maria, Kogkaki, Artemis, Athanasiou, Varvara, Mamais, Michael, Veclani, Daniele, Iatrou, Hermis, Venturini, Alessandro, Chrysina, Evangelia D, Papazafiri, Panagiota, Gimisis, Thanasis

“…Molecular rotors belong to a family of fluorescent compounds characterized as molecular switches, where a fluorescence on/off signal signifies a change in the…”
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Synthesis of N-glucopyranosidic derivatives as potential inhibitors that bind at the catalytic site of glycogen phosphorylase by Gimisis, Thanasis

“…Glycogen phosphorylase (GP) is a promising molecular target for the treatment of Type 2 diabetes. The design of potential inhibitors for the catalytic site of…”
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A New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site by Mamais, Michael, Degli Esposti, Alessandra, Kouloumoundra, Virginia, Gustavsson, Thomas, Monti, Filippo, Venturini, Alessandro, Chrysina, Evangelia D., Markovitsi, Dimitra, Gimisis, Thanasis

“…The design and synthesis of a glucose‐based acridone derivative (GLAC), a potent inhibitor of glycogen phosphorylase (GP) are described. GLAC is the first…”
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Synthesis of N4-aryl-β-d-glucopyranosylcytosines: a methodology study by Mamais, Michael, Kouloumoundra, Virginia, Smyrli, Eugenia, Grammatopoulos, Paschalis, Chrysina, Evangelia D., Gimisis, Thanasis

“…[Display omitted] A number of leaving groups, including arylsulfonates, triazoles, 3-nitrotriazoles, and tetrazoles, have been studied for the substitution…”
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Frontispiece: A New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site by Mamais, Michael, Degli Esposti, Alessandra, Kouloumoundra, Virginia, Gustavsson, Thomas, Monti, Filippo, Venturini, Alessandro, Chrysina, Evangelia D., Markovitsi, Dimitra, Gimisis, Thanasis

“…Glycogen phosphorylase (GP) plays a key role in glucose regulation. The design and synthesis of a new potent inhibitor of GP is described. By exploiting its…”
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Tautomerism in the Guanyl Radical by Chatgilialoglu, Chryssostomos, Caminal, Clara, Altieri, Alessio, Vougioukalakis, Georgios C, Mulazzani, Quinto G, Gimisis, Thanasis, Guerra, Maurizio

“…Despite a few decades of intense study, a full description of tautomers of one-electron-oxidized guanine remains to be achieved. Here we show that two of these…”
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A highly efficient synthesis of 3-methylcholanthrene by Gimisis, Thanasis, Koreeda, Masato

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exo- N-[2-(4-Azido-2,3,5,6-tetrafluorobenzamido)ethyl]-dC: a novel intermediate in the synthesis of dCTP derivatives for photoaffinity labelling by Cismaş, Crina, Gimisis, Thanasis

“…An alternative route for the synthesis of a photoaffinity labelling (PAL) dCTP derivative is reported. This method involves the intermediacy of exo-…”
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Independent Generation of C5‘-Nucleosidyl Radicals in Thymidine and 2‘-Deoxyguanosine by Manetto, Antonio, Georganakis, Dimitris, Leondiadis, Leondios, Gimisis, Thanasis, Mayer, Peter, Carell, Thomas, Chatgilialoglu, Chryssostomos

“…The synthesis of the C5‘ tert-butyl ketone of thymidine 1a and 2‘-deoxyguanosine 2 is achieved by reaction of 5‘-C-cyano derivatives with tert-butyl lithium…”
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Comparison of Isoelectronic 8-HO-G and 8-NH2-G Derivatives in Redox Processes by Kaloudis, Panagiotis, D’Angelantonio, Mila, Guerra, Maurizio, Spadafora, Marie, Cismaş, Crina, Gimisis, Thanasis, Mulazzani, Quinto G, Chatgilialoglu, Chryssostomos

“…8-Oxo-7,8-dihydroguanine (8-oxo-G) is the major lesion of oxidatively generated DNA damage. Despite two decades of intense study, several fundamental…”
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