Search Results - "Gilson, Eric"

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells by Marçais, Antoine, Cherfils-Vicini, Julien, Viant, Charlotte, Degouve, Sophie, Viel, Sébastien, Fenis, Aurore, Rabilloud, Jessica, Mayol, Katia, Tavares, Armelle, Bienvenu, Jacques, Gangloff, Yann-Gaël, Gilson, Eric, Vivier, Eric, Walzer, Thierry

“…The kinase mTOR is important in lymphocyte bioenergetics but has not been examined in natural killer cells. Walzer and colleagues demonstrate that mTOR is key…”
Get full text

Longevity clocks: The promoting role of telomeres? by Cherfils-Vicini, Julien, Gilson, Éric

“…Aging is an alteration of our physiological capacities that is accompanied by an increased susceptibility to develop a wide range of diseases and which…”
Get more information

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells by Nassour, Joe, Martien, Sébastien, Martin, Nathalie, Deruy, Emeric, Tomellini, Elisa, Malaquin, Nicolas, Bouali, Fatima, Sabatier, Laure, Wernert, Nicolas, Pinte, Sébastien, Gilson, Eric, Pourtier, Albin, Pluquet, Olivier, Abbadie, Corinne

“…The main characteristic of senescence is its stability which relies on the persistence of DNA damage. We show that unlike fibroblasts, senescent epithelial…”
Get full text

The Power of Stress: The Telo-Hormesis Hypothesis by Jacome Burbano, Maria Sol, Gilson, Eric

“…Adaptative response to stress is a strategy conserved across evolution to promote survival. In this context, the groundbreaking findings of Miroslav Radman on…”
Get full text

Length-dependent processing of telomeres in the absence of telomerase by Fallet, Emilie, Jolivet, Pascale, Soudet, Julien, Lisby, Michael, Gilson, Eric, Teixeira, Maria Teresa

“…In the absence of telomerase, telomeres progressively shorten with every round of DNA replication, leading to replicative senescence. In telomerase-deficient…”
Get full text

Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells by Cherfils‐Vicini, Julien, Gilson, Eric

“…In the context of tumorigenesis, telomere shortening is associated with apparent antagonistic outcomes: On one side, it favors cancer initiation through…”
Get full text

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection by Benarroch-Popivker, Delphine, Pisano, Sabrina, Mendez-Bermudez, Aaron, Lototska, Liudmyla, Kaur, Parminder, Bauwens, Serge, Djerbi, Nadir, Latrick, Chrysa M., Fraisier, Vincent, Pei, Bei, Gay, Alexandre, Jaune, Emilie, Foucher, Kevin, Cherfils-Vicini, Julien, Aeby, Eric, Miron, Simona, Londoño-Vallejo, Arturo, Ye, Jing, Le Du, Marie-Hélène, Wang, Hong, Gilson, Eric, Giraud-Panis, Marie-Josèphe

“…The shelterin proteins protect telomeres against activation of the DNA damage checkpoints and recombinational repair. We show here that a dimer of the…”
Get full text

Genetic and pharmacological inactivation of the purinergic P2RX7 receptor dampens inflammation but increases tumor incidence in a mouse model of colitis-associated cancer by Hofman, Paul, Cherfils-Vicini, Julien, Bazin, Marie, Ilie, Marius, Juhel, Thierry, Hébuterne, Xavier, Gilson, Eric, Schmid-Alliana, Annie, Boyer, Olivier, Adriouch, Sahil, Vouret-Craviari, Valérie

“…Colitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD). Binding of extracellular ATP to the purinergic receptor P2RX7 has…”
Get full text

Telomeric position effect: From the yeast paradigm to human pathologies? by Ottaviani, Alexandre, Gilson, Eric, Magdinier, Frédérique

“…Alteration of the epigenome is associated with a wide range of human diseases. Therefore, deciphering the pathways that regulate the epigenetic modulation of…”
Get full text

Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2 by Mendez-Bermudez, Aaron, Lototska, Liudmyla, Bauwens, Serge, Giraud-Panis, Marie-Josèphe, Croce, Olivier, Jamet, Karine, Irizar, Agurtzane, Mowinckel, Macarena, Koundrioukoff, Stephane, Nottet, Nicolas, Almouzni, Genevieve, Teulade-Fichou, Mare-Paule, Schertzer, Michael, Perderiset, Mylène, Londoño-Vallejo, Arturo, Debatisse, Michelle, Gilson, Eric, Ye, Jing

“…Hard-to-replicate regions of chromosomes (e.g., pericentromeres, centromeres, and telomeres) impede replication fork progression, eventually leading, in the…”
Get full text

Ecology of Endozoicomonadaceae in three coral genera across the Pacific Ocean by Hochart, Corentin, Paoli, Lucas, Ruscheweyh, Hans-Joachim, Salazar, Guillem, Boissin, Emilie, Romac, Sarah, Poulain, Julie, Bourdin, Guillaume, Iwankow, Guillaume, Moulin, Clémentine, Ziegler, Maren, Porro, Barbara, Armstrong, Eric J., Hume, Benjamin C. C., Aury, Jean-Marc, Pogoreutz, Claudia, Paz-García, David A., Nugues, Maggy M., Agostini, Sylvain, Banaigs, Bernard, Boss, Emmanuel, Bowler, Chris, de Vargas, Colomban, Douville, Eric, Flores, Michel, Forcioli, Didier, Furla, Paola, Gilson, Eric, Lombard, Fabien, Pesant, Stéphane, Reynaud, Stéphanie, Thomas, Olivier P., Troublé, Romain, Wincker, Patrick, Zoccola, Didier, Allemand, Denis, Planes, Serge, Thurber, Rebecca Vega, Voolstra, Christian R., Sunagawa, Shinichi, Galand, Pierre E.

“…Health and resilience of the coral holobiont depend on diverse bacterial communities often dominated by key marine symbionts of the Endozoicomonadaceae family…”
Get full text

Diversity of the Pacific Ocean coral reef microbiome by Galand, Pierre E., Ruscheweyh, Hans-Joachim, Salazar, Guillem, Hochart, Corentin, Henry, Nicolas, Hume, Benjamin C. C., Oliveira, Pedro H., Perdereau, Aude, Labadie, Karine, Belser, Caroline, Boissin, Emilie, Romac, Sarah, Poulain, Julie, Bourdin, Guillaume, Iwankow, Guillaume, Moulin, Clémentine, Armstrong, Eric J., Paz-García, David A., Ziegler, Maren, Agostini, Sylvain, Banaigs, Bernard, Boss, Emmanuel, Bowler, Chris, de Vargas, Colomban, Douville, Eric, Flores, Michel, Forcioli, Didier, Furla, Paola, Gilson, Eric, Lombard, Fabien, Pesant, Stéphane, Reynaud, Stéphanie, Thomas, Olivier P., Troublé, Romain, Zoccola, Didier, Voolstra, Christian R., Thurber, Rebecca Vega, Sunagawa, Shinichi, Wincker, Patrick, Allemand, Denis, Planes, Serge

“…Coral reefs are among the most diverse ecosystems on Earth. They support high biodiversity of multicellular organisms that strongly rely on associated…”
Get full text

Pervasive tandem duplications and convergent evolution shape coral genomes by Noel, Benjamin, Denoeud, France, Rouan, Alice, Buitrago-López, Carol, Capasso, Laura, Poulain, Julie, Boissin, Emilie, Pousse, Mélanie, Da Silva, Corinne, Couloux, Arnaud, Armstrong, Eric, Carradec, Quentin, Cruaud, Corinne, Labadie, Karine, Lê-Hoang, Julie, Tambutté, Sylvie, Barbe, Valérie, Moulin, Clémentine, Bourdin, Guillaume, Iwankow, Guillaume, Romac, Sarah, Agostini, Sylvain, Banaigs, Bernard, Boss, Emmanuel, Bowler, Chris, de Vargas, Colomban, Douville, Eric, Flores, J Michel, Forcioli, Didier, Furla, Paola, Galand, Pierre E, Lombard, Fabien, Pesant, Stéphane, Reynaud, Stéphanie, Sullivan, Matthew B, Sunagawa, Shinichi, Thomas, Olivier P, Troublé, Romain, Thurber, Rebecca Vega, Allemand, Denis, Planes, Serge, Gilson, Eric, Zoccola, Didier, Wincker, Patrick, Voolstra, Christian R, Aury, Jean-Marc

“…Over the last decade, several coral genomes have been sequenced allowing a better understanding of these symbiotic organisms threatened by climate change…”
Get full text

Role of the telomeric factor TRF2 in post-hypoxic brain damages by Gao, Shuaiyun, Huang, Sheng, Xu, Yiwen, Wang, Bo, Cheng, Peng, Lu, Yiming, Gilson, Eric, Ye, Jing

“…The neuronal excitotoxicity that follows reoxygenation after a hypoxic period may contribute to epilepsy, Alzheimer's disease, Parkinson's disease and various…”
Get full text

Host transcriptomic plasticity and photosymbiotic fidelity underpin Pocillopora acclimatization across thermal regimes in the Pacific Ocean by Armstrong, Eric J., Lê-Hoang, Julie, Carradec, Quentin, Aury, Jean-Marc, Noel, Benjamin, Hume, Benjamin C. C., Voolstra, Christian R., Poulain, Julie, Belser, Caroline, Paz-García, David A., Cruaud, Corinne, Labadie, Karine, Da Silva, Corinne, Moulin, Clémentine, Boissin, Emilie, Bourdin, Guillaume, Iwankow, Guillaume, Romac, Sarah, Agostini, Sylvain, Banaigs, Bernard, Boss, Emmanuel, Bowler, Chris, de Vargas, Colomban, Douville, Eric, Flores, Michel, Forcioli, Didier, Furla, Paola, Galand, Pierre E., Gilson, Eric, Lombard, Fabien, Pesant, Stéphane, Reynaud, Stéphanie, Sullivan, Matthew B., Sunagawa, Shinichi, Thomas, Olivier P., Troublé, Romain, Thurber, Rebecca Vega, Zoccola, Didier, Planes, Serge, Allemand, Denis, Wincker, Patrick

“…Heat waves are causing declines in coral reefs globally. Coral thermal responses depend on multiple, interacting drivers, such as past thermal exposure,…”
Get full text

Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition by Ghilain, Claire, Gilson, Eric, Giraud-Panis, Marie-Josèphe

“…Protecting telomere from the DNA damage response is essential to avoid the entry into cellular senescence and organismal aging. The progressive telomere DNA…”
Get full text

The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin by Bauwens, Serge, Lototska, Liudmyla, Koundrioukoff, Stephane, Debatisse, Michelle, Ye, Jing, Gilson, Eric, Mendez-Bermudez, Aaron

“…Heterochromatic regions render the replication process particularly difficult due to the high level of chromatin compaction and the presence of repeated DNA…”
Get full text

TRFH domain： at the root of telomere protein evolution by Giraud-Panis, Marie-Joseph, Ye, Jing, Gilson, Eric

“…Two articles in Cell Research focus on the structure-function relation- ships in the shelterin complex that binds to telomeres and is essential for their…”
Get full text

Nitric Oxide Synthase 2 Improves Proliferation and Glycolysis of Peripheral γδ T Cells by Douguet, Laetitia, Cherfils-Vicini, Julien, Bod, Lloyd, Lengagne, Renée, Gilson, Eric, Prévost-Blondel, Armelle

“…γδ T cells play critical roles in host defense against infections and cancer. Although advances have been made in identifying γδ TCR ligands, it remains…”
Get full text

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway by Rizzo, Angela, Salvati, Erica, Porru, Manuela, D’Angelo, Carmen, Stevens, Malcolm F., D’Incalci, Maurizio, Leonetti, Carlo, Gilson, Eric, Zupi, Gabriella, Biroccio, Annamaria

“…Functional telomeres are required to maintain the replicative ability of cancer cells and represent putative targets for G-quadruplex (G4) ligands. Here, we…”
Get full text