Search Results - "Gilpin, Sarah E."

Regeneration and experimental orthotopic transplantation of a bioengineered kidney by Song, Jeremy J, Guyette, Jacques P, Gilpin, Sarah E, Gonzalez, Gabriel, Vacanti, Joseph P, Ott, Harald C

“…Building on their earlier work on heart and lung organ engineering, Jeremy Song and his colleagues have now adapted the technology of using decellularized…”
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Bioengineering Human Myocardium on Native Extracellular Matrix by Guyette, Jacques P, Charest, Jonathan M, Mills, Robert W, Jank, Bernhard J, Moser, Philipp T, Gilpin, Sarah E, Gershlak, Joshua R, Okamoto, Tatsuya, Gonzalez, Gabriel, Milan, David J, Gaudette, Glenn R, Ott, Harald C

“…RATIONALE:More than 25 million individuals have heart failure worldwide, with ≈4000 patients currently awaiting heart transplantation in the United States…”
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Acellular human lung scaffolds to model lung disease and tissue regeneration by Gilpin, Sarah E, Wagner, Darcy E

“…Recent advances in whole lung bioengineering have opened new doors for studying lung repair and regeneration using acellular human derived lung tissue…”
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Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip by Bai, Haiqing, Si, Longlong, Jiang, Amanda, Belgur, Chaitra, Zhai, Yunhao, Plebani, Roberto, Oh, Crystal Yuri, Rodas, Melissa, Patil, Aditya, Nurani, Atiq, Gilpin, Sarah E., Powers, Rani K., Goyal, Girija, Prantil-Baun, Rachelle, Ingber, Donald E.

“…Mechanical breathing motions have a fundamental function in lung development and disease, but little is known about how they contribute to host innate…”
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Enhanced Lung Epithelial Specification of Human Induced Pluripotent Stem Cells on Decellularized Lung Matrix by Gilpin, Sarah E., PhD, Ren, Xi, PhD, Okamoto, Tatsuya, MD, PhD, Guyette, Jacques P., PhD, Mou, Hongmei, PhD, Rajagopal, Jayaraj, MD, Mathisen, Douglas J., MD, Vacanti, Joseph P., MD, Ott, Harald C., MD

“…Background Whole-lung scaffolds can be created by perfusion decellularization of cadaveric donor lungs. The resulting matrices can then be recellularized to…”
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Proteomic analysis of naturally-sourced biological scaffolds by Li, Qiyao, Uygun, Basak E, Geerts, Sharon, Ozer, Sinan, Scalf, Mark, Gilpin, Sarah E, Ott, Harald C, Yarmush, Martin L, Smith, Lloyd M, Welham, Nathan V, Frey, Brian L

“…Abstract A key challenge to the clinical implementation of decellularized scaffold-based tissue engineering lies in understanding the process of removing cells…”
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Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts by Kitano, Kentaro, Schwartz, Dana M., Zhou, Haiyang, Gilpin, Sarah E., Wojtkiewicz, Gregory R., Ren, Xi, Sommer, Cesar A., Capilla, Amalia V., Mathisen, Douglas J., Goldstein, Allan M., Mostoslavsky, Gustavo, Ott, Harald C.

“…Patients with short bowel syndrome lack sufficient functional intestine to sustain themselves with enteral intake alone. Transplantable vascularized…”
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Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis by Moeller, Antje, Gilpin, Sarah E, Ask, Kjetil, Cox, Gerard, Cook, Deborah, Gauldie, Jack, Margetts, Peter J, Farkas, Laszlo, Dobranowski, Julian, Boylan, Colm, O'Byrne, Paul M, Strieter, Robert M, Kolb, Martin

“…The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major challenge due to lack of effective drug therapy or accurate indicators for…”
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Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips by Izadifar, Zohreh, Cotton, Justin, Chen, Siyu, Horvath, Viktor, Stejskalova, Anna, Gulati, Aakanksha, LoGrande, Nina T., Budnik, Bogdan, Shahriar, Sanjid, Doherty, Erin R., Xie, Yixuan, To, Tania, Gilpin, Sarah E., Sesay, Adama M., Goyal, Girija, Lebrilla, Carlito B., Ingber, Donald E.

“…Modulation of the cervix by steroid hormones and commensal microbiome play a central role in the health of the female reproductive tract. Here we describe…”
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Bioengineering Lungs for Transplantation by Gilpin, Sarah E., PhD, Charest, Jonathan M., MS, Ren, Xi, PhD, Ott, Harald C., MD

“…Whole lung extracellular matrix scaffolds can be created by perfusion of cadaveric organs with decellularizing detergents, providing a platform for organ…”
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Assessment of Proliferation and Cytotoxicity in a Biomimetic Three-Dimensional Model of Lung Cancer by Tapias, Luis F., MD, Gilpin, Sarah E., PhD, Ren, Xi, PhD, Wei, Lan, PhD, Fuchs, Bryan C., PhD, Tanabe, Kenneth K., MD, Lanuti, Michael, MD, Ott, Harald C., MD

“…Background Decellularized whole-organ scaffolds show great potential in cancer research. They have been used in the biomimetic three-dimensional (3D) culture…”
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Using nature's platform to engineer bio-artificial lungs by Gilpin, Sarah E, Ott, Harald C

“…Native lung extracellular matrix can be isolated from cadaveric organs via perfusion decellularization and provides a novel scaffold material for lung…”
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AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage by Li, Juan, Wen, Amy M., Potla, Ratnakar, Benshirim, Ezekiel, Seebarran, Ariel, Benz, Maximilian A., Henry, Olivier Y. F., Matthews, Benjamin D., Prantil-Baun, Rachelle, Gilpin, Sarah E., Levy, Oren, Ingber, Donald E.

“…Enhanced vascular permeability in the lungs can lead to pulmonary edema, impaired gas exchange, and ultimately respiratory failure. While oxygen delivery,…”
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Perfusion decellularization of whole organs by Guyette, Jacques P, Gilpin, Sarah E, Charest, Jonathan M, Tapias, Luis F, Ren, Xi, Ott, Harald C

“…This describes how to decellularize whole organs using pressure-controlled perfusion, which enables preparation of acellular 3D scaffolds with preserved…”
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Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019 by Wagner, Darcy E, Ikonomou, Laertis, Gilpin, Sarah E, Magin, Chelsea M, Cruz, Fernanda, Greaney, Allison, Magnusson, Mattias, Chen, Ya-Wen, Davis, Brian, Vanuytsel, Kim, Rolandsson Enes, Sara, Krasnodembskaya, Anna, Lehmann, Mareike, Westergren-Thorsson, Gunilla, Stegmayr, John, Alsafadi, Hani N, Hoffman, Evan T, Weiss, Daniel J, Ryan, Amy L

“…A workshop entitled "Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Diseases" was hosted by the University of Vermont Larner College of…”
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Altered progenitor cell and cytokine profiles in bronchiolitis obliterans syndrome by Gilpin, Sarah E., PhD, Lung, Kalvin C., BSc, Sato, Masaaki, MD, PhD, Singer, Lianne G., MD, Keshavjee, Shaf, MD, MSc, Waddell, Thomas K., MD, MSc

“…Background Bone marrow–derived progenitor cells may play a key role in both lung repair and in fibrogenesis. The contribution of CD45+ collagen-1+ fibrocytes…”
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Bioengineering Human Lung Grafts on Porcine Matrix by Zhou, Haiyang, Kitano, Kentaro, Ren, Xi, Rajab, Taufiek Konrad, Wu, Min, Gilpin, Sarah E, Wu, Tong, Baugh, Lauren, Black, Lauren D, Mathisen, Douglas J, Ott, Harald C

“…OBJECTIVE:Bioengineering of viable, functional, and implantable human lung grafts on porcine matrix. SUMMARY BACKGROUND DATA:Implantable bioartificial organ…”
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Modeling pulmonary cystic fibrosis in a human lung airway-on-a-chip by Plebani, Roberto, Potla, Ratnakar, Soong, Mercy, Bai, Haiqing, Izadifar, Zohreh, Jiang, Amanda, Travis, Renee N., Belgur, Chaitra, Dinis, Alexandre, Cartwright, Mark J., Prantil-Baun, Rachelle, Jolly, Pawan, Gilpin, Sarah E., Romano, Mario, Ingber, Donald E.

“…•Human lung airway chip was created lined with cystic fibrosis patient cells.•Organ chip model recapitulates many features of cystic fibrosis lung in…”
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Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017. An Official American Thoracic Society Workshop Report by Ryan, Amy L., Ikonomou, Laertis, Atarod, Sadaf, Bölükbas, Deniz A., Collins, Jennifer, Freishtat, Rob, Hawkins, Finn, Gilpin, Sarah E., Uhl, Franziska E., Uriarte, Juan Jose, Weiss, Daniel J., Wagner, Darcy E.

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The molecular mechanisms of extracellular matrix-derived hydrogel therapy in idiopathic pulmonary fibrosis models by Evangelista-Leite, Daniele, Carreira, Ana C.O., Nishiyama, Milton Y., Gilpin, Sarah E., Miglino, Maria A.

“…Idiopathic Pulmonary Fibrosis (IPF) is a progressively debilitating lung condition characterized by oxidative stress, cell phenotype shifts, and excessive…”
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