Search Results - "Gilpin, Nicholas W."

Racial inequity in grant funding from the US National Institutes of Health by Taffe, Michael A, Gilpin, Nicholas W

“…Biomedical science and federal funding for scientific research are not immune to the systemic racism that pervades American society. A groundbreaking analysis…”
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The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders by Gilpin, Nicholas W, Herman, Melissa A, Roberto, Marisa

“…Abstract The central amygdala (CeA) plays a central role in physiologic and behavioral responses to fearful stimuli, stressful stimuli, and drug-related…”
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Central amygdala CRF1 cells control nociception and anxiety-like behavior by Weera, Marcus M, Gilpin, Nicholas W

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Effects of Chronic Nicotine Inhalation on Systemic and Pulmonary Blood Pressure and Right Ventricular Remodeling in Mice by Oakes, Joshua M., Xu, Jiaxi, Morris, Tamara M., Fried, Nicholas D., Pearson, Charlotte S., Lobell, Thomas D., Gilpin, Nicholas W., Lazartigues, Eric, Gardner, Jason D., Yue, Xinping

“…Cigarette smoking is the single most important risk factor for the development of cardiovascular and pulmonary diseases; however, the role of nicotine in the…”
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Positive allosteric modulation of the cannabinoid type-1 receptor (CB1R) in periaqueductal gray (PAG) antagonizes anti-nociceptive and cellular effects of a mu-opioid receptor agonist in morphine-withdrawn rats by Datta, Udita, Kelley, Leslie K., Middleton, Jason W., Gilpin, Nicholas W.

“…Opioid drugs are a first-line treatment for severe acute pain and other chronic pain conditions, but long-term opioid drug use produces opioid-induced…”
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Adolescent binge drinking leads to changes in alcohol drinking, anxiety, and amygdalar corticotropin releasing factor cells in adulthood in male rats by Gilpin, Nicholas W, Karanikas, Chrisanthi A, Richardson, Heather N

“…Heavy episodic drinking early in adolescence is associated with increased risk of addiction and other stress-related disorders later in life. This suggests…”
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Animal models of post-traumatic stress disorder and recent neurobiological insights by Whitaker, Annie M, Gilpin, Nicholas W, Edwards, Scott

“…Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder characterized by the intrusive re-experiencing of past trauma, avoidant behavior,…”
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The Role of Melanocortin Plasticity in Pain-Related Outcomes After Alcohol Exposure by Sharfman, Nathan, Gilpin, Nicholas W

“…The global COVID-19 pandemic has shone a light on the rates and dangers of alcohol misuse in adults and adolescents in the US and globally. Alcohol exposure…”
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Sex differences in traumatic stress reactivity in rats with and without a history of alcohol drinking by Albrechet-Souza, Lucas, Schratz, Connor L, Gilpin, Nicholas W

“…Alcohol misuse and post-traumatic stress disorder (PTSD) are highly comorbid, and treatment outcomes are worse in individuals with both conditions. Although…”
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Corticotropin Releasing Factor–Induced Amygdala Gamma-Aminobutyric Acid Release Plays a Key Role in Alcohol Dependence by Roberto, Marisa, Cruz, Maureen T, Gilpin, Nicholas W, Sabino, Valentina, Schweitzer, Paul, Bajo, Michal, Cottone, Pietro, Madamba, Samuel G, Stouffer, David G, Zorrilla, Eric P, Koob, George F, Siggins, George R, Parsons, Loren H

“…Background Corticotropin-releasing factor (CRF) and gamma-aminobutyric acid (GABA)ergic systems in the central amygdala (CeA) are implicated in the…”
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Traumatic Stress Promotes Hyperalgesia via Corticotropin-Releasing Factor-1 Receptor (CRFR1) Signaling in Central Amygdala by Itoga, Christy A, Roltsch Hellard, Emily A, Whitaker, Annie M, Lu, Yi-Ling, Schreiber, Allyson L, Baynes, Brittni B, Baiamonte, Brandon A, Richardson, Heather N, Gilpin, Nicholas W

“…Hyperalgesia is an exaggerated response to noxious stimuli produced by peripheral or central plasticity. Stress modifies nociception, and humans with…”
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Generation of a CRF1-Cre transgenic rat and the role of central amygdala CRF1 cells in nociception and anxiety-like behavior by Weera, Marcus M, Agoglia, Abigail E, Douglass, Eliza, Jiang, Zhiying, Rajamanickam, Shivakumar, Shackett, Rosetta S, Herman, Melissa A, Justice, Nicholas J, Gilpin, Nicholas W

“…Corticotropin-releasing factor type-1 (CRF 1 ) receptors are critical to stress responses because they allow neurons to respond to CRF released in response to…”
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Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala by Gilpin, Nicholas W., Roberto, Marisa, Koob, George F., Schweitzer, Paul

“…Activation of the kappa opioid receptor (KOR) system mediates negative emotional states and considerable evidence suggests that KOR and their natural ligand,…”
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Nicotine Downregulates the Compensatory Angiotensin-Converting Enzyme 2/Angiotensin Type 2 Receptor of the Renin-Angiotensin System by Yue, Xinping, Basting, Tyler M, Flanagan, Thomas W, Xu, Jiaxi, Lobell, Thomas D, Gilpin, Nicholas W, Gardner, Jason D, Lazartigues, Eric

“…Smoking is a major risk factor for the development of cardiovascular and pulmonary diseases. The importance of the renin-angiotensin system in the development…”
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Amygdalar endocannabinoids are affected by predator odor stress in a sex-specific manner and modulate acoustic startle reactivity in female rats by Albrechet-Souza, Lucas, Nastase, Andrei S., Hill, Matthew N., Gilpin, Nicholas W.

“…Understanding sex differences in behavioral and molecular effects of stress has important implications for understanding the vulnerability to chronic…”
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Alcohol Modulation of Cardiac Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of MMPs Favors Collagen Accumulation by El Hajj, Elia C., El Hajj, Milad C., Voloshenyuk, Tetyana G., Mouton, Alan J., Khoutorova, Elena, Molina, Patricia E., Gilpin, Nicholas W., Gardner, Jason D.

“…Background Chronic alcohol consumption has been shown in human and animal studies to result in collagen accumulation, myocardial fibrosis, and heart failure…”
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Brain reward and stress systems in addiction by Gilpin, Nicholas W

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Synaptic GABAergic transmission in the central amygdala (CeA) of rats depends on slice preparation and recording conditions by Avegno, Elizabeth M., Middleton, Jason W., Gilpin, Nicholas W.

“…The central nucleus of the amygdala (CeA) is a primarily GABAergic brain region implicated in stress and addictive disorders. Using in vitro slice…”
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The predator odor avoidance model of post-traumatic stress disorder in rats by Albrechet-Souza, Lucas, Gilpin, Nicholas W

“…Individuals with post-traumatic stress disorder avoid trauma-related stimuli and exhibit blunted hypothalamic–pituitary–adrenal axis response at the time of…”
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Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats by Aldridge, Gabriel M., Zarin, Tyler A., Brandner, Adam J., George, Olivier, Gilpin, Nicholas W., Repunte-Canonigo, Vez, Sanna, Pietro Paolo, Koob, George F., Vendruscolo, Leandro F., Schmeichel, Brooke E.

“…Hypocretin/orexin (HCRT) is a neuropeptide that is associated with both stress and reward systems in humans and rodents. The different contributions of…”
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