Search Results - "Gilpatrick, Timothy"

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc by Delmore, Jake E., Issa, Ghayas C., Lemieux, Madeleine E., Rahl, Peter B., Shi, Junwei, Jacobs, Hannah M., Kastritis, Efstathios, Gilpatrick, Timothy, Paranal, Ronald M., Qi, Jun, Chesi, Marta, Schinzel, Anna C., McKeown, Michael R., Heffernan, Timothy P., Vakoc, Christopher R., Bergsagel, P. Leif, Ghobrial, Irene M., Richardson, Paul G., Young, Richard A., Hahn, William C., Anderson, Kenneth C., Kung, Andrew L., Bradner, James E., Mitsiades, Constantine S.

“…MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to modulate the function of the c-Myc oncoprotein do not exist. Toward this…”
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Characterization of human telomerase reverse transcriptase promoter methylation and transcription factor binding in differentiated thyroid cancer cell lines by Avin, Brittany A., Wang, Yongchun, Gilpatrick, Timothy, Workman, Rachael E., Lee, Isac, Timp, Winston, Umbricht, Christopher B., Zeiger, Martha A.

“…Telomerase reverse transcriptase (TERT) activation plays an important role in cancer development by enabling the immortalization of cells. TERT regulation is…”
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Reprogramming of Polycomb-Mediated Gene Silencing in Embryonic Stem Cells by the miR-290 Family and the Methyltransferase Ash1l by Kanellopoulou, Chryssa, Gilpatrick, Timothy, Kilaru, Gokhul, Burr, Patrick, Nguyen, Cuong K., Morawski, Aaron, Lenardo, Michael J., Muljo, Stefan A.

“…Members of the miR-290 family are the most abundantly expressed microRNAs (miRNAs) in mouse embryonic stem cells (ESCs). They regulate aspects of…”
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Targeted nanopore sequencing with Cas9-guided adapter ligation by Gilpatrick, Timothy, Lee, Isac, Graham, James E., Raimondeau, Etienne, Bowen, Rebecca, Heron, Andrew, Downs, Bradley, Sukumar, Saraswati, Sedlazeck, Fritz J, Timp, Winston

“…Despite recent improvements in sequencing methods, there remains a need for assays that provide high sequencing depth and comprehensive variant detection…”
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Simultaneous profiling of chromatin accessibility and methylation on human cell lines with nanopore sequencing by Lee, Isac, Razaghi, Roham, Gilpatrick, Timothy, Molnar, Michael, Gershman, Ariel, Sadowski, Norah, Sedlazeck, Fritz J., Hansen, Kasper D., Simpson, Jared T., Timp, Winston

“…Probing epigenetic features on DNA has tremendous potential to advance our understanding of the phased epigenome. In this study, we use nanopore sequencing to…”
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Age and Race-Based Differences in Anal Cytology: Implications for Screening and Prevention of Anal Cancer Disparities: A Single Institutional Study by Gilpatrick, Timothy, Long, Steven, Mousavi, Seyedreza, Samghabadi, Peyman, Vohra, Poonam

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Characterization of Allele-Specific Regulation of Telomerase Reverse Transcriptase in Promoter Mutant Thyroid Cancer Cell Lines by McKelvey, Brittany A, Gilpatrick, Timothy, Wang, Yongchun, Timp, Winston, Umbricht, Christopher B, Zeiger, Martha A

“…Telomerase reverse transcriptase ( ) promoter mutations play a role in carcinogenesis and are found in both tumors and cancer cell lines. promoter methylation,…”
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Long read mitochondrial genome sequencing using Cas9-guided adaptor ligation by Vandiver, Amy R., Pielstick, Brittany, Gilpatrick, Timothy, Hoang, Austin N., Vernon, Hillary J., Wanagat, Jonathan, Timp, Winston

“…•Cas9-guided adaptor ligation for nanopore sequencing allows amplification free enrichment of the mitochondrial genome (mtDNA) in long read sequencing,…”
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Signal Analysis of Nanopore RNA Sequencing to Interrogate Poly(A) Tails and Post-Transcriptional Modifications by Razaghi, Roham, Gilpatrick, Timothy, Sadowski, Norah, Tang, Paul, Workman, Rachael, Simpson, Jared, Timp, Winston

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Targeted nanopore sequencing with Cas9-guided adaptor ligation by Gilpatrick, Timothy, Lee, Isac, Graham, James E., Raimondeau, Etienne, Bowen, Rebecca, Heron, Andrew, Downs, Bradley, Sukmar, Saraswati, Sedlazeck, Fritz J, Timp, Winston

“…Despite recent improvements in sequencing methods, there remains a need for assays that provide high sequencing depth and comprehensive variant detection…”
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Nanopore native RNA sequencing of a human poly(A) transcriptome by Workman, Rachael E., Tang, Alison D., Tang, Paul S., Jain, Miten, Tyson, John R., Razaghi, Roham, Zuzarte, Philip C., Gilpatrick, Timothy, Payne, Alexander, Quick, Joshua, Sadowski, Norah, Holmes, Nadine, de Jesus, Jaqueline Goes, Jones, Karen L., Soulette, Cameron M., Snutch, Terrance P., Loman, Nicholas, Paten, Benedict, Loose, Matthew, Simpson, Jared T., Olsen, Hugh E., Brooks, Angela N., Akeson, Mark, Timp, Winston

“…High-throughput complementary DNA sequencing technologies have advanced our understanding of transcriptome complexity and regulation. However, these methods…”
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Author Correction: Nanopore native RNA sequencing of a human poly(A) transcriptome by Workman, Rachael E., Tang, Alison D., Tang, Paul S., Jain, Miten, Tyson, John R., Razaghi, Roham, Zuzarte, Philip C., Gilpatrick, Timothy, Payne, Alexander, Quick, Joshua, Sadowski, Norah, Holmes, Nadine, de Jesus, Jaqueline Goes, Jones, Karen L., Soulette, Cameron M., Snutch, Terrance P., Loman, Nicholas, Paten, Benedict, Loose, Matthew, Simpson, Jared T., Olsen, Hugh E., Brooks, Angela N., Akeson, Mark, Timp, Winston

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Examining the Role of Lipoprotein‐Associated Phospholipase A2 in Atherosclerosis by Gilpatrick, Timothy Edward, Tomczak, Jonathan, Bahnson, Brian J.

“…Abstract only Interest in the enzyme Lipoprotein Associated Phospholipase A2 (Lp‐PLA2) emerged when it was recognized to be elevated in patients at risk for…”
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Inhibition of c-Myc Expression and Function in Hematologic Malignancies by Issa, Ghayas C, Delmore, Jake E, McKeown, Michael R, Lemieux, Madeleine E, Rahl, Peter B, Jacobs, Hannah M., Kastritis, Efstathios, Gilpatrick, Timothy, Paranal, Ronald M, Qi, Jun, Shi, Junwei, Chesi, Marta, Schinzel, Anna C., Vakoc, Christopher R., Bergsagel, P.Leif, Richardson, Paul G., Young, Richard, Hahn, William C., Ghobrial, Irene M., Anderson, Kenneth C, Kung, Andrew L., Mitsiades, Constantine S., Bradner, James E

“…Abstract 1409 MYC is among the most prolific oncogenes in cancer, yet pharmacologic strategies to modulate the function of the c-Myc oncoprotein do not exist…”
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