PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers

PRIMAGE is one of the largest and more ambitious research projects dealing with medical imaging, artificial intelligence and cancer treatment in children. It is a 4-year European Commission-financed project that has 16 European partners in the consortium, including the European Society for Paediatri...

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Bibliographic Details
Published in:	European radiology experimental Vol. 4; no. 1; p. 22
Main Authors:	Martí-Bonmatí, Luis, Alberich-Bayarri, Ángel, Ladenstein, Ruth, Blanquer, Ignacio, Segrelles, J. Damian, Cerdá-Alberich, Leonor, Gkontra, Polyxeni, Hero, Barbara, García-Aznar, J. M., Keim, Daniel, Jentner, Wolfgang, Seymour, Karine, Jiménez-Pastor, Ana, González-Valverde, Ismael, Martínez de las Heras, Blanca, Essiaf, Samira, Walker, Dawn, Rochette, Michel, Bubak, Marian, Mestres, Jordi, Viceconti, Marco, Martí-Besa, Gracia, Cañete, Adela, Richmond, Paul, Wertheim, Kenneth Y., Gubala, Tomasz, Kasztelnik, Marek, Meizner, Jan, Nowakowski, Piotr, Gilpérez, Salvador, Suárez, Amelia, Aznar, Mario, Restante, Giuliana, Neri, Emanuele
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 03-04-2020 Springer Nature B.V SpringerOpen
Subjects:	Artificial Intelligence Biomarkers Biomarkers (tumour) Biomarkers - analysis Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - therapy Child Cloud Computing Decision Support Techniques Diagnostic Radiology Diffuse intrinsic pontine glioma Disease Progression Europe Female Glioma Glioma - diagnostic imaging Glioma - therapy Humans Imaging Internal Medicine Interventional Radiology Male Medicine Medicine & Public Health Neuroblastoma Neuroblastoma - diagnostic imaging Neuroblastoma - therapy Neuroradiology Original Original Article Phenotype Prognosis Radiology Tumor Burden Ultrasound Europe Cloud computing Neuroblastoma Artificial intelligence Diffuse intrinsic pontine glioma Biomarkers (tumour)
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Summary:	PRIMAGE is one of the largest and more ambitious research projects dealing with medical imaging, artificial intelligence and cancer treatment in children. It is a 4-year European Commission-financed project that has 16 European partners in the consortium, including the European Society for Paediatric Oncology, two imaging biobanks, and three prominent European paediatric oncology units. The project is constructed as an observational in silico study involving high-quality anonymised datasets (imaging, clinical, molecular, and genetics) for the training and validation of machine learning and multiscale algorithms. The open cloud-based platform will offer precise clinical assistance for phenotyping (diagnosis), treatment allocation (prediction), and patient endpoints (prognosis), based on the use of imaging biomarkers, tumour growth simulation, advanced visualisation of confidence scores, and machine-learning approaches. The decision support prototype will be constructed and validated on two paediatric cancers: neuroblastoma and diffuse intrinsic pontine glioma. External validation will be performed on data recruited from independent collaborative centres. Final results will be available for the scientific community at the end of the project, and ready for translation to other malignant solid tumours.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Undefined-2
ISSN:	2509-9280 2509-9280
DOI:	10.1186/s41747-020-00150-9