Search Results - "Gilon, Chaim"

Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified by Beck, Johannes G, Chatterjee, Jayanta, Laufer, Burkhardt, Kiran, Marelli Udaya, Frank, Andreas O, Neubauer, Stefanie, Ovadia, Oded, Greenberg, Sarit, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…Insufficient oral bioavailability is considered as a key limitation for the widespread development of peptides as therapeutics. While the oral bioavailability…”
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The tripartite mechanism as the basis for a biochemical memory engram by Marx, Gerard, Gilon, Chaim

“…In this paper, we address the enigma of the memory engram, the physical trace of memory in terms of its composition, processes, and location. A neurochemical…”
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Development of Clarstatin, a Novel Drug Lead for the Therapy of Autoimmune Uveitis by Merzbach, Shira, Hoffman, Amnon, Lazarovici, Philip, Gilon, Chaim, Amer, Radgonde

“…We describe the design, synthesis, and activity of a potent thiourea-bridged backbone cyclic peptidomimetic known as Clarstatin, comprising a 5-amino acid…”
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Synthesis of Novel Arginine Building Blocks with Increased Lipophilicity Compatible with Solid-Phase Peptide Synthesis by Glavaš, Mladena, Gitlin-Domagalska, Agata, Ptaszyńska, Natalia, Starego, Dominika, Freza, Sylwia, Dębowski, Dawid, Helbik-Maciejewska, Aleksandra, Łęgowska, Anna, Gilon, Chaim, Rolka, Krzysztof

“…Arginine, due to the guanidine moiety, increases peptides' hydrophilicity and enables interactions with charged molecules, but at the same time, its presence…”
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The Effect of Multiple N-Methylation on Intestinal Permeability of Cyclic Hexapeptides by Ovadia, Oded, Greenberg, Sarit, Chatterjee, Jayanta, Laufer, Burkhardt, Opperer, Florian, Kessler, Horst, Gilon, Chaim, Hoffman, Amnon

“…Recent progress in peptide synthesis simplified the synthesis of multiple N-methylation of peptides. To evaluate how multiple N-methylation affects the…”
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Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway by Schumacher-Klinger, Adi, Fanous, Joseph, Merzbach, Shira, Weinmüller, Michael, Reichart, Florian, Räder, Andreas F. B, Gitlin-Domagalska, Agata, Gilon, Chaim, Kessler, Horst, Hoffman, Amnon

“…Hydrophilic peptides constitute most of the active peptides. They mostly permeate via tight junctions (paracellular pathway) in the intestine. This…”
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Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults by Gilon, Chaim, Gitlin-Domagalska, Agata, Lahiani, Adi, Yehoshua- Alshanski, Shiran, Shumacher-Klinger, Adi, Gilon, Dan, Taha, Mahmoud, Sekler, Israel, Hoffman, Amnon, Lazarovici, Philip

“…[Display omitted] •Humanin is a cytoprotective, 24-amino acid mitochondrial-derived peptide.•Humanin novel synthetic analogs HUJInin and c(D-Ser14-HN) were…”
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Conversion of Protein Active Regions into Peptidomimetic Therapeutic Leads Using Backbone Cyclization and Cycloscan - How to Do it Yourself by Rubin, Samuel J S, Tal-Gan, Yftah, Gilon, Chaim, Qvit, Nir

“…Protein-protein Interactions (PPIs) are particularly important for controlling both physiologic and pathologic biological processes but are difficult to target…”
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Deciphering Direct and Indirect Effects of Neurokinin B and GnRH in the Brain-Pituitary Axis of Tilapia by Mizrahi, Naama, Gilon, Chaim, Atre, Ishwar, Ogawa, Satoshi, Parhar, Ishwar S, Levavi-Sivan, Berta

“…Neurokinin B (NKB) and its cognate receptor (NK3R) are emerging as important components of the neuroendocrine regulation of reproduction. Unlike mammalian ,…”
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Structure-Activity Relationship of Synthetic Linear KTS-Peptides Containing Meta-Aminobenzoic Acid as Antagonists of α1β1 Integrin with Anti-Angiogenic and Melanoma Anti-Tumor Activities by Naamneh, Majdi Saleem, Momic, Tatjana, Klazas, Michal, Grosche, Julius, Eble, Johannes A, Marcinkiewicz, Cezary, Khazanov, Netaly, Senderowitz, Hanoch, Hoffman, Amnon, Gilon, Chaim, Katzhendler, Jehoshua, Lazarovici, Philip

“…To develop peptide drugs targeting integrin receptors, synthetic peptide ligands endowed with well-defined selective binding motifs are necessary. The snake…”
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DMAP-assisted sulfonylation as an efficient step for the methylation of primary amine motifs on solid support by Naoum, Johnny N, Chandra, Koushik, Shemesh, Dorit, Gerber, R Benny, Gilon, Chaim, Hurevich, Mattan

“…Several multistep strategies were developed to ensure single methylation of amines on solid support. These strategies rely on the introduction of the -NBS…”
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A small shared epitope-mimetic compound potently accelerates osteoclast-mediated bone damage in autoimmune arthritis by Fu, Jiaqi, Ling, Song, Liu, Ying, Yang, Jianyi, Naveh, Shirly, Hannah, Margaret, Gilon, Chaim, Zhang, Yang, Holoshitz, Joseph

“…We have recently proposed that the shared epitope (SE) may contribute to rheumatoid arthritis pathogenesis by acting as a ligand that activates…”
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Treatment with αvβ3-integrin-specific 29P attenuates pressure-overload induced cardiac remodelling after transverse aortic constriction in mice by Njegić, Alexandra, Laid, Lina, Zi, Min, Maniati, Eleni, Wang, Jun, Chelu, Alexandru, Wisniewski, Laura, Hunter, Jenna, Prehar, Sukhpal, Stafford, Nicholas, Gilon, Chaim, Hoffman, Amnon, Weinmüller, Michael, Kessler, Horst, Cartwright, Elizabeth J., Hodivala-Dilke, Kairbaan

“…Heart failure remains one of the largest clinical burdens globally, with little to no improvement in the development of disease-eradicating therapeutics…”
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The Molecular Basis of Neural Memory. Part 7: Neural Intelligence (NI) versus Artificial Intelligence (AI) by Marx, Gerard, Gilon, Chaim

“…The link of memory to intelligence is incontestable, though the development of electronic artifacts with memory has confounded cognitive and computer…”
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Cyclizing Painkillers: Development of Backbone-Cyclic TAPS Analogs by Talhami, Alaa, Swed, Avi, Hess, Shmuel, Ovadia, Oded, Greenberg, Sarit, Schumacher-Klinger, Adi, Rosenthal, David, Shalev, Deborah E., Hurevich, Mattan, Lazarovici, Philip, Hoffman, Amnon, Gilon, Chaim

“…Painkillers are commonly used medications. Native peptide painkillers suffer from various pharmacological disadvantages, while small molecule painkillers like…”
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Backbone Cyclic Peptidomimetic Melanocortin-4 Receptor Agonist as a Novel Orally Administrated Drug Lead for Treating Obesity by Hess, Shmuel, Linde, Yaniv, Ovadia, Oded, Safrai, Eli, Shalev, Deborah E, Swed, Avi, Halbfinger, Efrat, Lapidot, Tair, Winkler, Ilan, Gabinet, Yael, Faier, Avi, Yarden, Dana, Xiang, Zhimin, Portillo, Federico P, Haskell-Luevano, Carrie, Gilon, Chaim, Hoffman, Amnon

“…The tetrapeptide sequence His-Phe-Arg-Trp, derived from melanocyte-stimulating hormone (αMSH) and its analogs, causes a decrease in food intake and elevates…”
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Allosteric inhibition of g-protein coupled receptor oligomerization: strategies and challenges for drug development by Hurevich, Mattan, Talhami, Alaa, Shalev, Deborah E, Gilon, Chaim

“…G-protein coupled receptors (GPCRs) mediate a large number of biological pathways and are major therapeutic targets. One of the most exiting phenomena of GPCRs…”
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The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: The melanocortin agonist paradigm by Ovadia, Oded, Linde, Yaniv, Haskell-Luevano, Carrie, Dirain, Marvin L., Sheynis, Tanya, Jelinek, Raz, Gilon, Chaim, Hoffman, Amnon

“…General structure of peptides, peptoids, peptomers and backbone cyclic peptomers. A peptide–peptoid hybrid (peptomer) library was designed and synthesized,…”
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Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis by Gilon, Chaim, Klazas, Michal, Lahiani, Adi, Schumacher-Klinger, Adi, Merzbach, Shira, Naoum, Johnny N, Ovadia, Haim, Rubin, Limor, Cornell-Kennon, Susan, Schaefer, Erik M, Katzhendler, Jehoshua, Marcinkiewicz, Cezary, Hoffman, Amnon, Lazarovici, Philip

“…Integrins α4β1/ α9β1 are important in the pathogenesis and progression of inflammatory and autoimmune diseases by their roles in leukocyte activation and…”
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Oxytocin-Monolayer-Based Impedimetric Biosensor for Zinc and Copper Ions by Tadi, Kiran Kumar, Alshanski, Israel, Mervinetsky, Evgeniy, Marx, Gerard, Petrou, Panayiota, Dimitrios, Karussis M, Gilon, Chaim, Hurevich, Mattan, Yitzchaik, Shlomo

“…Zinc and copper are essential metal ions for numerous biological processes. Their levels are tightly maintained in all body organs. Impairment of the Zn2+ to…”
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