Search Results - "Gilmore, Linda"

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation by Morgan, Hugh P., O'Reilly, Francis J., Wear, Martin A., O'Neill, J. Robert, Fothergill-Gilmore, Linda A., Hupp, Ted, Walkinshaw, Malcolm D.

“…We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between monomers and tetramers regulated by allosteric binding of naturally…”
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Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis by Zhong, Wenhe, Cui, Liang, Goh, Boon Chong, Cai, Qixu, Ho, Peiying, Chionh, Yok Hian, Yuan, Meng, Sahili, Abbas El, Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D., Lescar, Julien, Dedon, Peter C.

“…Pyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in all organisms, with tight…”
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Incorporating physical activities in teaching practice by Gilmore, Linda, Sullivan, Karen A., Hughes, Brenda

“…Although the value of physical activity for physical and mental health is well accepted, benefits for learning are less clear. Research about the incorporation…”
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An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor by Yuan, Meng, McNae, Iain W, Chen, Yiyuan, Blackburn, Elizabeth A, Wear, Martin A, Michels, Paul A M, Fothergill-Gilmore, Linda A, Hupp, Ted, Walkinshaw, Malcolm D

“…We have tested the effect of all 20 proteinogenic amino acids on the activity of the M2 isoenzyme of pyruvate kinase (M2PYK) and show that, within…”
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Moringa Oleifera Seed Extract Concomitantly Supplemented with Chemotherapy Worsens Tumor Progression in Mice with Triple Negative Breast Cancer and Obesity by Zunica, Elizabeth R. M., Yang, Shengping, Coulter, Ann, White, Christy, Kirwan, John P., Gilmore, Linda A.

“…Triple negative breast cancer (TNBC) is an aggressive and highly metastatic breast cancer subtype with limited treatment options. Obesity and insulin…”
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Intellectual disability and sexuality: Attitudes of disability support staff and leisure industry employees by Gilmore, Linda, Chambers, Brooke

“…Background The attitudes of support staff and others in the community towards the sexuality of individuals with an intellectual disability (ID) have the…”
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Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism by Zhong, Wenhe, Li, Kuohan, Cai, Qixu, Guo, Jingjing, Yuan, Meng, Wong, Yee Hwa, Walkinshaw, Malcolm D., Fothergill-Gilmore, Linda A., Michels, Paul A.M., Dedon, Peter C., Lescar, Julien

“…During its intra-erythrocytic growth phase, the malaria parasite Plasmodium falciparum relies heavily on glycolysis for its energy requirements. Pyruvate…”
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'It's a Lot Trickier than I Expected': Assessment Issues and Dilemmas for Intern Psychologists by Gilmore, Linda, Campbell, Marilyn

“…Beyond the basic information provided in foundation texts and test manuals, there is a notable scarcity of professional literature addressing complex issues…”
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The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site by Morgan, Hugh P., McNae, Iain W., Nowicki, Matthew W., Zhong, Wenhe, Michels, Paul A.M., Auld, Douglas S., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.

“…Ehrlich's pioneering chemotherapeutic experiments published in 1904 (Ehrlich, P., and Shiga, K. (1904) Berlin Klin. Wochenschrift 20, 329–362) described the…”
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Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis by Zhong, Wenhe, Guo, Jingjing, Cui, Liang, Chionh, Yok Hian, Li, Kuohan, El Sahili, Abbas, Cai, Qixu, Yuan, Meng, Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D., Mu, Yuguang, Lescar, Julien, Dedon, Peter C.

“…In response to the stress of infection, Mycobacterium tuberculosis (Mtb) reprograms its metabolism to accommodate nutrient and energetic demands in a changing…”
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Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition by Yuan, Meng, Vásquez-Valdivieso, Montserrat G., McNae, Iain W., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.

“…The gluconeogenic enzyme fructose-1,6-bisphosphatase has been proposed as a potential drug target against Leishmania parasites that cause up to 20,000–30,000…”
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Modifications to Infant Formula Instructions Improve the Accuracy of Formula Dispensing by Gilmore, Linda A, Altazan, Abby D, Flanagan, Emily W, Beyer, Alexandra G, Olson, Kelsey N, O'Connell, Alexis A, Nguyen, Timothy H, Beyl, Robbie A, Redman, Leanne M

“…Readability of infant formula preparation instructions is universally poor, which may result in inaccurate infant feeding. Given that inaccurate formula…”
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Allosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock Model by Morgan, Hugh P., McNae, Iain W., Nowicki, Matthew W., Hannaert, Véronique, Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.

“…Allosteric regulation provides a rate management system for enzymes involved in many cellular processes. Ligand-controlled regulation is easily recognizable,…”
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A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase by Morgan, Hugh P, Walsh, Martin J, Blackburn, Elizabeth A, Wear, Martin A, Boxer, Matthew B, Shen, Min, Veith, Henrike, McNae, Iain W, Nowicki, Matthew W, Michels, Paul A M, Auld, Douglas S, Fothergill-Gilmore, Linda A, Walkinshaw, Malcolm D

“…PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems…”
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Changing student teachers' attitudes towards disability and inclusion by Campbell, Jennifer, Gilmore, Linda, Cuskelly, Monica

“…A total of 274 preservice teacher education students were surveyed at the beginning and end of a one-semester unit on Human Development and Education which…”
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Parenting satisfaction and self-efficacy: A longitudinal study of mothers of children with Down syndrome by Gilmore, Linda, Cuskelly, Monica

“…Continuities and changes in parenting sense of competence were examined for mothers of children with Down syndrome from early childhood to adolescence. The…”
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Development of the Dimensions of Adult Mastery Motivation Questionnaire by Doherty-Bigara, Jacqueline, Gilmore, Linda

“…Mastery motivation is an important developmental construct that has implications for development across the lifespan. Research to date has focused…”
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Pyruvate kinases have an intrinsic and conserved decarboxylase activity by Zhong, Wenhe, Morgan, Hugh P, Nowicki, Matthew W, McNae, Iain W, Yuan, Meng, Bella, Juraj, Michels, Paul A M, Fothergill-Gilmore, Linda A, Walkinshaw, Malcolm D

“…The phosphotransfer mechanism of PYKs (pyruvate kinases) has been studied in detail, but the mechanism of the intrinsic decarboxylase reaction catalysed by…”
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Examination of a Scale Assessing Attitudes towards Individuals with Intellectual Disability in China by Su, Hui, Cuskelly, Monica, Gilmore, Linda, Sullivan, Karen

“…This study examined the applicability of the four-factor structure of the short form of the Community Living Attitudes Scale-Intellectual Disability 1 1 We…”
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Adapting Evidence-Based Interventions for Students with Developmental Disabilities by Gilmore, Linda, Campbell, Marilyn, Shochet, Ian

“…Students with developmental disabilities have many challenges with learning and adaptive behaviour, as well as a higher prevalence rate of mental health…”
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