Search Results - "Gilmore, D"

Evolutionary Origins of Toll-like Receptor Signaling by Brennan, Joseph J, Gilmore, Thomas D

“…Toll-like receptors (TLRs) are transmembrane pattern recognition receptors that are best known for their roles in innate immunity for the detection of and…”
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An innate ability: How do basal invertebrates manage their chronic exposure to microbes? by Williams, Leah M, Gilmore, Thomas D

“…Homologs of mammalian innate immune sensing and downstream pathway proteins have been discovered in a variety of basal invertebrates, including cnidarians and…”
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NF-κB and Human Cancer: What Have We Learned over the Past 35 Years? by Gilmore, Thomas D.

“…Transcription factor NF-κB has been extensively studied for its varied roles in cancer development since its initial characterization as a potent retroviral…”
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Control of apoptosis by Rel/NF-κB transcription factors by BARKETT, M, GILMORE, T. D

“…Apoptosis is a physiological process critical for organ development, tissue homeostasis, and elimination of defective or potentially dangerous cells in complex…”
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Concise total syntheses of (-)-jorunnamycin A and (-)-jorumycin enabled by asymmetric catalysis by Welin, Eric R, Ngamnithiporn, Aurapat, Klatte, Max, Lapointe, Guillaume, Pototschnig, Gerit M, McDermott, Martina S J, Conklin, Dylan, Gilmore, Christopher D, Tadross, Pamela M, Haley, Christopher K, Negoro, Kenji, Glibstrup, Emil, Grünanger, Christian U, Allan, Kevin M, Virgil, Scott C, Slamon, Dennis J, Stoltz, Brian M

“…The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer…”
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Orthogonal Synthesis of Indolines and Isoquinolines via Aryne Annulation by Gilmore, Christopher D, Allan, Kevin M, Stoltz, Brian M

“…Described in this report is the development of two unique methodologies exploiting the reactivity of arynes. Reaction of N-carbamoyl-functionalized enamine…”
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Rapid profiling of transcription factor-cofactor interaction networks reveals principles of epigenetic regulation by Inge, Melissa M, Miller, Rebekah, Hook, Heather, Bray, David, Keenan, Jessica L, Zhao, Rose, Gilmore, Thomas D, Siggers, Trevor

“…Transcription factor (TF)-cofactor (COF) interactions define dynamic, cell-specific networks that govern gene expression; however, these networks are…”
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The c-Rel Transcription Factor in Development and Disease by Gilmore, Thomas D, Gerondakis, Steve

“…c-Rel is a member of the nuclear factor κB (NF-κB) transcription factor family. Unlike other NF-κB proteins that are expressed in a variety of cell types, high…”
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The Rel/NF-κB signal transduction pathway : introduction by GILMORE, T. D

“…Rel/NF- Kappa B transcription factors include a collection of proteins, conserved from Drosophila to humans. Among model organisms, these transcription factors…”
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Transcription factor NF-κB is modulated by symbiotic status in a sea anemone model of cnidarian bleaching by Mansfield, Katelyn M., Carter, Nicole M., Nguyen, Linda, Cleves, Phillip A., Alshanbayeva, Anar, Williams, Leah M., Crowder, Camerron, Penvose, Ashley R., Finnerty, John R., Weis, Virginia M., Siggers, Trevor W., Gilmore, Thomas D.

“…Transcription factor NF-κB plays a central role in immunity from fruit flies to humans, and NF-κB activity is altered in many human diseases. To investigate a…”
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Analysis of variable major protein antigenic variation in the relapsing fever spirochete, Borrelia miyamotoi, in response to polyclonal antibody selection pressure by Gilmore, Robert D, Armstrong, Brittany A, Brandt, Kevin S, Van Gundy, Taylor J, Hojgaard, Andrias, Lopez, Job E, Kneubehl, Alexander R

“…Borrelia miyamotoi is a tick-transmitted spirochete that is genetically grouped with relapsing fever Borrelia and possesses multiple archived pseudogenes that…”
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Good cop, bad cop: the different faces of NF-κB by Perkins, N D, Gilmore, T D

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Human neuroglial cells internalize Borrelia burgdorferi by coiling phagocytosis mediated by Daam1 by Williams, Shanna K, Weiner, Zachary P, Gilmore, Robert D

“…Borrelia burgdorferi, the agent of Lyme borreliosis, can elude hosts' innate and adaptive immunity as part of the course of infection. The ability of B…”
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Intraspecific variation in oxidative stress tolerance in a model cnidarian: Differences in peroxide sensitivity between and within populations of Nematostella vectensis by Friedman, Lauren E, Gilmore, Thomas D, Finnerty, John R

“…Nematostella vectensis is a member of the phylum Cnidaria, a lineage that includes anemones, corals, hydras, and jellyfishes. This estuarine anemone is an…”
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Variations in structural MRI quality significantly impact commonly used measures of brain anatomy by Gilmore, Alysha D., Buser, Nicholas J., Hanson, Jamie L.

“…Subject motion can introduce noise into neuroimaging data and result in biased estimations of brain structure. In-scanner motion can compromise data quality in…”
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Borrelia miyamotoi BipA-like protein, BipM, is a candidate serodiagnostic antigen distinguishing between Lyme disease and relapsing fever Borrelia infections by Brandt, Kevin S., Armstrong, Brittany A., Goodrich, Irina, Gilmore, Robert D.

“…A Borrelia miyamotoi gene with partial homology to bipA of relapsing fever spirochetes Borrelia hermsii and Borrelia turicatae was identified by a GenBank…”
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Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid by Zakeyah, A.A., Whitt, J., Duke, C., Gilmore, D.F., Meeker, D.G., Smeltzer, M.S., Alam, M.A.

“…[Display omitted] •Benign synthesis of new pyrazole derivatives.•29 novel molecules.•MIC as low as 0.78 μM (S. aureus, MRSA, B. subtilis, and A…”
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Serologic Proteome Analysis of Borrelia burgdorferi Membrane-Associated Proteins by Nowalk, Andrew J, Gilmore, Robert D. Jr, Carroll, James A

“…Lyme disease, a global health concern, is caused by infection with Borrelia burgdorferi, B. afzelii, or B. garinii. The spirochete responsible for the disease…”
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4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents by Hansa, Raj KC, Khan, M.M.K., Frangie, M.M., Gilmore, D.F., Shelton, R.S., Savenka, A.V., Basnakian, A.G., Shuttleworth, S.L., Smeltzer, M.S., Alam, M.A.

“…A collection of potent antimicrobials consisting of novel 1,3-bis-benzoic acid and trifluoromethyl phenyl derived pyrazoles has been synthesized and tested for…”
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Transcription factor cross-talk: the estrogen receptor and NF-κB by Kalaitzidis, Demetrios, Gilmore, Thomas D.

“…The NF-κB family of transcription factors regulates many genes that are essential primarily for the development, maintenance and function of the innate and…”
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