Search Results - "Gilmer, TM"

Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells by KONECNY, Gottfried E, PEGRAM, Mark D, KEITH, Barry R, GILMER, Tona M, BERGER, Mark, PODRATZ, Karl C, SLAMON, Dennis J, VENKATESAN, Natarajan, FINN, Richard, GUORONG YANG, RAHMEH, Martina, UNTCH, Michael, RUSNAK, David W, SPEHAR, Glenn, MULLIN, Robert J

“…Lapatinib (GW572016) is a selective inhibitor of both epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. Here, we explore the therapeutic…”
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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells by WOOD, Edgar R, TRUESDALE, Anne T, ALLIGOOD, Krystal J, RUSNAK, David W, GILMER, Tona M, SHEWCHUK, Lisa, MCDONALD, Octerloney B, YUAN, Derek, HASSELL, Anne, DICKERSON, Scott H, ELLIS, Byron, PENNISI, Christopher, HORNE, Earnest, LACKEY, Karen

“…GW572016 (Lapatinib) is a tyrosine kinase inhibitor in clinical development for cancer that is a potent dual inhibitor of epidermal growth factor receptor…”
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The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth of Human Normal and Tumor-derived Cell Lines in Vitro and in Vivo by Rusnak, D W, Lackey, K, Affleck, K, Wood, E R, Alligood, K J, Rhodes, N, Keith, B R, Murray, D M, Knight, W B, Mullin, R J, Gilmer, T M

“…The epidermal growth factor receptor (EGFR) and ErbB-2 transmembrane tyrosine kinases are currently being targeted by various mechanisms in the treatment of…”
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The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer by RUSNAK, David W, AFFLECK, Karen, JOWETT, Amanda, STABLES, Jeremy, TOPLEY, Peter, WOOD, Edgar R, BRIGNOLA, Perry S, KADWELL, Sue H, REEP, Bryan R, MULLIN, Robert J, ALLIGOOD, Krystal J, KEITH, Barry R, COCKERILL, Stuart G, CROSBY, Renae M, MURRAY, Doris M, KNIGHT, W. Blaine, GILMER, Tona M, LACKEY, Karen, STUBBERFIELD, Colin, HARRIS, Robert, PAGE, Martin, SMITH, Kathryn J, GUNTRIP, Stephen B, CARTER, Malcolm C, SHAW, Robert J

“…The type I receptor tyrosine kinases constitute a family of transmembrane proteins involved in various aspects of cell growth and survival and have been…”
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S5-3: Basement Membrane Localized Tumor Cells Are Protected from HER2−Targeted Therapy In Vivo by Zoeller, JJ, Bronson, RT, Gilmer, TM, Selfors, LM, Lu, Y, Mills, GB, Brugge, JS

“…Abstract Drug resistance compromises the efficacy of HER2−targeted therapy. Results from our laboratory, and previous reports from others, indicate that tumor…”
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Abstract P4-08-05: Basement membrane localized tumor cells are protected from HER2-targeted therapy in vivo by Zoeller, JJ, Bronson, RT, Gilmer, TM, Selfors, LM, Lu, Y, Apple, SK, Press, MF, Hurvitz, SA, Slamon, DJ, Mills, GB, Brugge, JS

“…Abstract Drug resistance compromises the efficacy of HER2-targeted therapy. Results from our laboratory, and previous reports from others, indicate that tumor…”
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Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen by Smith, Martin L., I.-Tsuen Chen, Zhan, Qimin, Bae, Insoo, Chen, Chaw-Yuan, Gilmer, Tona M., Kastan, Michael B., O'Connor, Patrick M., Fornace, Albert J.

“…GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21$^{WAF1/CIP1}$,…”
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Growth factor modulation of p53-mediated growth arrest versus apoptosis by Canman, C E, Gilmer, T M, Coutts, S B, Kastan, M B

“…Irradiation of mammalian cells can cause cell cycle perturbations and apoptotic cell death. We have investigated the modulation of these physiologic end points…”
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Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation by Xia, Ling, Wang, Lijuan, Chung, Alicia S, Ivanov, Stanimir S, Ling, Mike Y, Dragoi, Ana M, Platt, Adam, Gilmer, Tona M, Fu, Xin-Yuan, Chin, Y Eugene

“…The cytoplasmic region of human epidermal growth factor receptor (EGFR) contains an intrinsic tyrosine kinase (697–955) followed by a 231-residue-long…”
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Discovery and Biological Evaluation of Potent Dual ErbB-2/EGFR Tyrosine Kinase Inhibitors: 6-Thiazolylquinazolines by Gaul, Micheal D, Guo, Yu, Affleck, Karen, Cockerill, G.Stuart, Gilmer, Tona M, Griffin, Robert J, Guntrip, Stephen, Keith, Barry R, Knight, Wilson B, Mullin, Robert J, Murray, Doris M, Rusnak, David W, Smith, Kathryn, Tadepalli, Sarva, Wood, Edgar R, Lackey, Karen

“…We have identified a novel class of 6-thiazolylquinazolines as potent and selective inhibitors of both ErbB-2 and EGFR tyrosine kinase activity, with IC 50…”
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A simple method for predicting serum protein binding of compounds from IC50 shift analysis for in vitro assays by RUSNAK, David W, ZHIHONG LAI, LANSING, Timothy J, RHODES, Nelson, GILMER, Tona M, COPELAND, Robert A

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The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization by Goldman, SC, Chen, CY, Lansing, TJ, Gilmer, TM, Kastan, MB

“…Mutations of the p53 tumor suppressor gene are rarely found in neuroblastoma. Though typically a nuclear protein, a number of tumor cell types have recently…”
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Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers by Clark, G J, Kinch, M S, Gilmer, T M, Burridge, K, Der, C J

“…Although experimental studies suggest that aberrant Ras function can promote the malignant progression of human breast epithelial cells, the occurrence of…”
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Characterization of human Gadd45, a p53-regulated protein by Carrier, F, Smith, M L, Bae, I, Kilpatrick, K E, Lansing, T J, Chen, C Y, Engelstein, M, Friend, S H, Henner, W D, Gilmer, T M

“…GADD45 (growth arrest and DNA damage) is a DNA-damage-inducible gene regulated in part by the tumor suppressor p53. A role in negative growth control has…”
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Expression and Purification of Active Recombinant ATM Protein from Transiently Transfected Mammalian Cells by Rhodes, Nelson, Gilmer, Tona M., Lansing, Timothy J.

“…The gene mutated in the human disease ataxia telangiectasia (AT), termed ATM, encodes a large protein kinase involved in DNA repair and cell cycle control…”
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ras mutations and expression in head and neck squamous cell carcinomas by Yarbrough, W G, Shores, C, Witsell, D L, Weissler, M C, Fidler, M E, Gilmer, T M

“…Mutational activation and overexpression of the family of ras proto-oncogenes have been associated with many human tumors. The role of mutations of H-ras,…”
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Induction of Gene Amplification by Arsenic by Lee, Te-Chang, Tanaka, Noriho, Lamb, Patricia W., Gilmer, Tona M., Barrett, J. Carl

“…Arsenic is a well-established carcinogen in humans, but there is little evidence for its carcinogenicity in animals and it is inactive as an initiator or tumor…”
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Defective potassium currents in ataxia telangiectasia fibroblasts by Rhodes, N, D'Souza, T, Foster, C D, Ziv, Y, Kirsch, D G, Shiloh, Y, Kastan, M B, Reinhart, P H, Gilmer, T M

“…Similarities exist between the progressive cerebellar ataxia in ataxia telangiectasia (AT) patients and a number of neurodegenerative diseases in both mouse…”
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Nonrandom loss of chromosome 15 in Syrian hamster tumours induced by v-Ha- ras plus v- myc oncogenes by Oshimura, Mitsuo, Gilmer, Tona M, Barrett, J. Carl

“…Nonrandom chromosome rearrangements, observed in a variety of human and animal tumours, are associated in some cases with enhanced expression or deregulation…”
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The formation of a covalent complex between a dipeptide ligand and the src SH2 domain by Alligood, Krystal J., Charifson, Paul S., Crosby, Renae, Consler, Thomas G., Feldman, Paul L., Gampe, Robert T., Gilmer, Tona M., Jordan, Steven R., Milstead, Mark W., Mohr, Christopher, Peel, Michael R., Rocque, Warren, Rodriguez, Marc, Rusnak, David W., Shewchuk, Lisa M., Sternbach, Daniel D.

“…The X-ray crystal structure of the src SH2 domain revealed the presence of a thiol residue (Cys 188) located proximal to the phosphotyrosine portion of a…”
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