Search Results - "Gillrie, Mark R"

An on-chip model of protein paracellular and transcellular permeability in the microcirculation by Offeddu, Giovanni S., Haase, Kristina, Gillrie, Mark R., Li, Ran, Morozova, Olga, Hickman, Dean, Knutson, Charles G., Kamm, Roger D.

“…Recent therapeutic success of large-molecule biologics has led to intense interest in assays to measure with precision their transport across the vascular…”
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Pericytes Contribute to Dysfunction in a Human 3D Model of Placental Microvasculature through VEGF‐Ang‐Tie2 Signaling by Haase, Kristina, Gillrie, Mark R., Hajal, Cynthia, Kamm, Roger D.

“…Placental vasculopathies are associated with a number of pregnancy‐related diseases, including pre‐eclampsia (PE)—a leading cause of maternal–fetal morbidity…”
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Vascular traffic control of neutrophil recruitment to the liver by microbiota-endothelium crosstalk by Zucoloto, Amanda Z., Schlechte, Jared, Ignacio, Aline, Thomson, Carolyn A., Pyke, Shannon, Yu, Ian-ling, Geuking, Markus B., McCoy, Kathy D., Yipp, Bryan G., Gillrie, Mark R., McDonald, Braedon

“…During bloodstream infections, neutrophils home to the liver as part of an intravascular immune response to eradicate blood-borne pathogens, but the mechanisms…”
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Case report: Immune profiling links neutrophil and plasmablast dysregulation to microvascular damage in post-COVID-19 Multisystem Inflammatory Syndrome in Adults (MIS-A) by Gillrie, Mark R, Rosin, Nicole, Sinha, Sarthak, Kang, Hellen, Farias, Raquel, Nguyen, Angela, Volek, Kelsie, Mah, Jordan, Mahe, Etienne, Fritzler, Marvin J, Yipp, Bryan G, Biernaskie, Jeff

“…Despite surviving a SARS-CoV-2 infection, some individuals experience an intense post-infectious Multisystem Inflammatory Syndrome (MIS) of uncertain etiology…”
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Microfluidic‐Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease by Serrano, Jean C., Gillrie, Mark R., Li, Ran, Ishamuddin, Sarah H., Moeendarbary, Emad, Kamm, Roger D.

“…The knowledge of the blood microvasculature and its functional role in health and disease has grown significantly attributable to decades of research and…”
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Prolonged SARS-CoV-2 infection following rituximab treatment: clinical course and response to therapeutic interventions correlated with quantitative viral cultures and cycle threshold values by Thornton, Christina S, Huntley, Kevin, Berenger, Byron M, Bristow, Michael, Evans, David H, Fonseca, Kevin, Franko, Angela, Gillrie, Mark R, Lin, Yi-Chan, Povitz, Marcus, Shafey, Mona, Conly, John M, Tremblay, Alain

“…Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is completed through reverse transcriptase-PCR (RT-PCR) from either oropharyngeal…”
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Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin by Cholera, Rushina, Brittain, Nathaniel J, Gillrie, Mark R, Lopera-Mesa, Tatiana M, Diakité, Séidina A.S, Arie, Takayuki, Krause, Michael A, Guindo, Aldiouma, Tubman, Abby, Fujioka, Hisashi, Diallo, Dapa A, Doumbo, Ogobara K, Ho, May, Wellems, Thomas E, Fairhurst, Rick M

“…Sickle trait, the heterozygous state of normal hemoglobin A (HbA) and sickle hemoglobin S (HbS), confers protection against malaria in Africa. AS children…”
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Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor by Offeddu, Giovanni S., Cambria, Elena, Shelton, Sarah E., Haase, Kristina, Wan, Zhengpeng, Possenti, Luca, Nguyen, Huu Tuan, Gillrie, Mark R., Hickman, Dean, Knutson, Charles G., Kamm, Roger D.

“…Desmoplasia in breast cancer leads to heterogeneity in physical properties of the tissue, resulting in disparities in drug delivery and treatment efficacy…”
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CD36 recruits α₅β₁ integrin to promote cytoadherence of P. falciparum-infected erythrocytes by Davis, Shevaun P, Lee, Kristine, Gillrie, Mark R, Roa, Lina, Amrein, Matthias, Ho, May

“…The adhesion of Plasmodium falciparum-infected erythrocytes (IRBC) to receptors on different host cells plays a divergent yet critical role in determining the…”
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Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model by Haase, Kristina, Offeddu, Giovanni S., Gillrie, Mark R., Kamm, Roger D.

“…Drug discovery and efficacy in cancer treatments are limited by the inability of pre‐clinical models to predict successful outcomes in humans. Limitations…”
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Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence by Gillrie, Mark R, Renaux, Bernard, Russell-Goldman, Eleanor, Avril, Marion, Brazier, Andrew J, Mihara, Koichiro, Di Cera, Enrico, Milner, Jr, Danny A, Hollenberg, Morley D, Smith, Joseph D, Ho, May

“…Plasmodium falciparum malaria remains one of the most deadly infections worldwide. The pathogenesis of the infection results from the sequestration of infected…”
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Omentum-on-a-chip: A multicellular, vascularized microfluidic model of the human peritoneum for the study of ovarian cancer metastases by Ibrahim, Lina I., Hajal, Cynthia, Offeddu, Giovanni S., Gillrie, Mark R., Kamm, Roger D.

“…Epithelial ovarian cancer has the highest mortality rate of any gynecologic malignancy and most frequently metastasizes to the peritoneal cavity…”
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Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19 by Sinha, Sarthak, Rosin, Nicole L., Arora, Rohit, Labit, Elodie, Jaffer, Arzina, Cao, Leslie, Farias, Raquel, Nguyen, Angela P., de Almeida, Luiz G. N., Dufour, Antoine, Bromley, Amy, McDonald, Braedon, Gillrie, Mark R., Fritzler, Marvin J., Yipp, Bryan G., Biernaskie, Jeff

“…Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics…”
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Eggerthella lenta Bloodstream Infections Are Associated With Increased Mortality Following Empiric Piperacillin-Tazobactam (TZP) Monotherapy: A Population-based Cohort Study by Ugarte-Torres, Alejandra, Gillrie, Mark R, Griener, Thomas P, Church, Deirdre L

“…Eggerthella lenta bloodstream infections are increasingly recognized, often caused by intraabdominal infections and associated with high mortality. Eggerthella…”
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Leukotriene B4-Mediated Neutrophil Recruitment Causes Pulmonary Capillaritis during Lethal Fungal Sepsis by Lee, Esther K.S., Gillrie, Mark R., Li, Lu, Arnason, Jason W., Kim, Jung Hwan, Babes, Liane, Lou, Yuefei, Sanati-Nezhad, Amir, Kyei, Stephen K., Kelly, Margaret M., Mody, Christopher H., Ho, May, Yipp, Bryan G.

“…Candida albicans bloodstream infection causes fungal septicaemia and death in over half of afflicted patients. Polymorphonuclear leukocytes (PMN) mediate…”
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Diverse functional outcomes of Plasmodium falciparum ligation of EPCR: potential implications for malarial pathogenesis by Gillrie, Mark R., Avril, Marion, Brazier, Andrew J., Davis, Shevaun P., Stins, Monique F., Smith, Joseph D., Ho, May

“…Summary Plasmodium falciparum‐infected erythrocytes (IRBC) expressing the domain cassettes (DC) 8 and 13 of the cytoadherent ligand P. falciparum erythrocyte…”
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Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction by Gillrie, Mark R, Lee, Kristine, Gowda, D. Channe, Davis, Shevaun P, Monestier, Marc, Cui, Liwang, Hien, Tran Tinh, Day, Nicholas P.J, Ho, May

“…Plasmodium falciparum is a protozoan parasite of human erythrocytes that causes the most severe form of malaria. Severe P. falciparum infection is associated…”
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Dynamic interactions of Plasmodium spp. with vascular endothelium by Gillrie, Mark R., Ho, May

“…Plasmodial species are protozoan parasites that infect erythrocytes. As such, they are in close contact with microvascular endothelium for most of the life…”
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Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor (Adv. Sci. 38/2024) by Offeddu, Giovanni S., Cambria, Elena, Shelton, Sarah E., Haase, Kristina, Wan, Zhengpeng, Possenti, Luca, Nguyen, Huu Tuan, Gillrie, Mark R., Hickman, Dean, Knutson, Charles G., Kamm, Roger D.

“…Vascularized Patient‐Derived Tumoroid Confocal microscopy image of a patient‐derived tumoroid, vascularized by perfusable microvascular networks in a…”
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Plasmodium falciparum‐induced CD36 clustering rapidly strengthens cytoadherence via p130CAS‐mediated actin cytoskeletal rearrangement by Davis, Shevaun P., Amrein, Matthias, Gillrie, Mark R., Lee, Kristine, Muruve, Daniel A., Ho, May

“…The adhesion of infected red blood cells (IRBCs) to microvascular endothelium is critical in the pathogenesis of severe malaria. Here we used atomic force and…”
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