Search Results - "Gillis, Ad JM"

Defining minimum genomic regions of imbalance involved in testicular germ cell tumors of adolescents and adults through genome wide microarray analysis of cDNA clones by MCINTYRE, Alan, SUMMERSGILL, Brenda, CLARK, Jeremy, SHIPLEY, Janet, JAFER, Osman, RODRIGUEZ, Sandrine, ZAFARANA, Gaetano, OOSTERHUIS, J. Wolter, GILLIS, Ad J. M, LOOIJENGA, Leendert, COOPER, Colin, HUDDART, Robert

“…Identifying changes in DNA copy number can pinpoint genes that may be involved in tumor development. Here we have defined the smallest overlapping regions of…”
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A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors by Voorhoeve, P. Mathijs, le Sage, Carlos, Schrier, Mariette, Gillis, Ad J.M., Stoop, Hans, Nagel, Remco, Liu, Ying-Poi, van Duijse, Josyanne, Drost, Jarno, Griekspoor, Alexander, Zlotorynski, Eitan, Yabuta, Norikazu, De Vita, Gabriella, Nojima, Hiroshi, Looijenga, Leendert H.J., Agami, Reuven

“…Endogenous small RNAs (miRNAs) regulate gene expression by mechanisms conserved across metazoans. While the number of verified human miRNAs is still expanding,…”
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Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance by Wermann, Hendrik, Stoop, Hans, Gillis, Ad JM, Honecker, Friedemann, van Gurp, Ruud JHLM, Ammerpohl, Ole, Richter, Julia, Oosterhuis, J. Wolter, Bokemeyer, Carsten, Looijenga, Leendert HJ

“…Differences in the global methylation pattern, ie hyper- as well as hypo-methylation, are observed in cancers including germ cell tumours (GCTs). Related to…”
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Endogenous Nodal signaling regulates germ cell potency during mammalian testis development by Spiller, Cassy M, Feng, Chun-Wei, Jackson, Andrew, Gillis, Ad J M, Rolland, Antoine D, Looijenga, Leendert H J, Koopman, Peter, Bowles, Josephine

“…Germ cells, the embryonic precursors of sperm or oocytes, respond to molecular cues that regulate their sex-specific development in the fetal gonads. In males…”
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Identification and Validation Model for Informative Liquid Biopsy-Based microRNA Biomarkers: Insights from Germ Cell Tumor In Vitro, In Vivo and Patient-Derived Data by Lobo, João, Gillis, Ad J M, van den Berg, Annette, Dorssers, Lambert C J, Belge, Gafanzer, Dieckmann, Klaus-Peter, Roest, Henk P, van der Laan, Luc J W, Gietema, Jourik, Hamilton, Robert J, Jerónimo, Carmen, Henrique, Rui, Salvatori, Daniela, Looijenga, Leendert H J

“…Liquid biopsy-based biomarkers, such as microRNAs, represent valuable tools for patient management, but often do not make it to integration in the clinic. We…”
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Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors by Killian, J Keith, Dorssers, Lambert C J, Trabert, Britton, Gillis, Ad J M, Cook, Michael B, Wang, Yonghong, Waterfall, Joshua J, Stevenson, Holly, Smith, Jr, William I, Noyes, Natalia, Retnakumar, Parvathy, Stoop, J Hans, Oosterhuis, J Wolter, Meltzer, Paul S, McGlynn, Katherine A, Looijenga, Leendert H J

“…Testicular germ cell tumors (TGCTs) share germline ancestry but diverge phenotypically and clinically as seminoma (SE) and nonseminoma (NSE), the latter…”
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Expression of BLIMP1/PRMT5and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors by Eckert, Dawid, Biermann, Katharina, Nettersheim, Daniel, Gillis, Ad JM, Steger, Klaus, Jäck, Hans-Martin, Müller, Annette M, Looijenga, Leendert HJ, Schorle, Hubert

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Genomic and expression profiling of human spermatocytic seminomas : Primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene by LOOIJENGA, Leendert H. J, HERSMUS, Remko, REIJO PERA, Renee, SCHNEIDER, Dominik T, SUMMERSGILL, Brenda, SHIPLEY, Janet, MCLNTYRE, Alan, VAN DER SPEK, Peter, SCHOENMAKERS, Eric, OOSTERHUIS, J. Wolter, GILLIS, Ad J. M, PFUNDT, Rolph, STOOP, Hans J, VAN GURP, Ruud J. H. L. M, VELTMAN, Joris, BEVERLOO, H. Berna, VAN DRUNEN, Ellen, VAN KESSEL, Ad Geurts

“…Spermatocytic seminomas are solid tumors found solely in the testis of predominantly elderly individuals. We investigated these tumors using a genome-wide…”
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NANOG promoter methylation and expression correlation during normal and malignant human germ cell development by Nettersheim, Daniel, Biermann, Katharina, Gillis, Ad J.M., Steger, Klaus, Looijenga, Leendert H.J., Schorle, Hubert

“…Testicular germ cell tumors are the most frequent malignant tumors in young Caucasian males, with increasing incidence. The actual model of tumorigenesis is…”
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Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults by MCLNTYRE, Alan, SUMMERSGILL, Brenda, CLARK, Jeremy, OOSTERHUIS, J. Wolter, LOOIJENGA, Leendert H. J, SHIPLEY, Janet, GRYGALEWICZ, Beata, GILLIS, Ad J. M, STOOP, J, VAN GURP, Ruud J. H. L. M, DENNIS, Nening, FISHER, Cyril, HUDDART, Robert, COOPER, Colin

“…We have previously identified amplification at 4q12 in testicular germ cell tumors of adolescents and adults centered around the KIT gene encoding a tyrosine…”
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Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors by Eckert, Dawid, Biermann, Katharina, Nettersheim, Daniel, Gillis, Ad J M, Steger, Klaus, Jäck, Hans-Martin, Müller, Annette M, Looijenga, Leendert H J, Schorle, Hubert

“…Most testicular germ cell tumors arise from intratubular germ cell neoplasia unclassified (IGCNU, also referred to as carcinoma in situ), which is thought to…”
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Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas: e1003384 by Basten, Sander G, Davis, Erica E, Gillis, Ad JM, Rooijen, Ellen van, Stoop, Hans, Babala, Nikolina, Logister, Ive, Heath, Zachary G, Jonges, Trudy N, Katsanis, Nicholas, Voest, Emile E, Eeden, Freek Jvan, Medema, Rene H, Ketting, René F, Schulte-Merker, Stefan, Looijenga, Leendert HJ, Giles, Rachel H

“…Seminoma is a subclass of human testicular germ cell tumors (TGCT), the most frequently observed cancer in young men with a rising incidence. Here we describe…”
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IGF2/H19 imprinting analysis of human germ cell tumors (GCTs) using the methylation-sensitive single-nucleotide primer extension method reflects the origin of GCTs in different stages of primordial germ cell development by Sievers, Sonja, Alemazkour, Katayoun, Zahn, Susanne, Perlman, Elizabeth J., Gillis, Ad J. M., Looijenga, Leendert H. J., Göbel, Ulrich, Schneider, Dominik T.

“…Previous studies have demonstrated biallelic expression of the imprinted genes H19 and IGF2 and loss of DNA methylation of the SNRPN gene, indicating a common…”
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Unique expression patterns of H19 in human testicular cancers of different etiology by VERKERK, A. J. M. H, ARIE, I, DEKKER, M. C, SCHNEIDER, T, VAN GURP, R. J. L. M, DE GROOT, N, GILLIS, A. J. M, OOSTERHUIS, J. W, HOCHBERG, A. A, LOOIJENGA, L. H

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Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors: e0122146 by Rijlaarsdam, Martin A, Tax, David MJ, Gillis, Ad JM, Dorssers, Lambert CJ, Koestler, Devin C, Ridder, Jeroen de, Looijenga, Leendert HJ

“…The cell of origin of the five subtypes (I-V) of germ cell tumors (GCTs) are assumed to be germ cells from different maturation stages. This is (potentially)…”
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Seminoma and Embryonal Carcinoma Footprints Identified by Analysis of Integrated Genome-Wide Epigenetic and Expression Profiles of Germ Cell Cancer Cell Lines: e98330 by Zwan, G vander, Rijlaarsdam, Martin A, Rossello, Fernando J, Notini, Amanda J, Boer, Suzan de, Watkins, D Neil, Gillis, Ad JM, Dorssers, Lambert CJ, White, Stefan J, Looijenga, Leendert HJ

“…Background Originating from Primordial Germ Cells/gonocytes and developing via a precursor lesion called Carcinoma In Situ (CIS), Germ Cell Cancers (GCC) are…”
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Genomic and expression profiling of human spermatocytic seminomas: pathogenetic implications by Looijenga, Leendert H.J, Stoop, Hans, Hersmus, Remko, Gillis, Ad J.M, Wolter Oosterhuis, J

“…Traditionally, germ cell tumours (GCTs) have been classified based on their histological appearance, i.e. the differentiation of lineages. Various subtypes of…”
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