Search Results - "Gillian Q. Horn"
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Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro
Published in Frontiers in immunology (28-09-2022)“…Human B cells encompass functionally diverse lineages and phenotypic states that contribute to protective as well as pathogenic responses. Epstein-Barr virus…”
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High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire
Published in PLoS pathogens (28-11-2022)“…Antibodies targeting the human malaria parasite Plasmodium falciparum circumsporozoite protein (PfCSP) can prevent infection and disease. PfCSP contains…”
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Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein
Published in Cell reports (Cambridge) (28-11-2023)“…IGHV3-33-encoded antibodies are prevalent in the human humoral response against the Plasmodium falciparum circumsporozoite protein (PfCSP). Among VH3-33…”
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TitrationAnalysis : a tool for high throughput binding kinetics data analysis for multiple label-free platforms
Published in Gates open research (2023)“…Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics…”
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Cryptic-site-specific antibodies to the SARS-CoV-2 receptor binding domain can retain functional binding affinity to spike variants
Published in Journal of virology (21-12-2023)“…Multiple SARS-CoV-2 variants of concern have emerged and caused a significant number of infections and deaths worldwide. These variants of concern contain…”
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Higher antigen occupancy of high avidity CSP serum antibodies associates with protection against human malaria
Published in Biophysical journal (10-02-2023)Get full text
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Simulated microgravity-mediated reversion of murine lymphoma immune evasion
Published in Scientific reports (10-10-2019)“…No human has returned to the moon since the end of the Apollo program 47 years ago, however, new missions are planned for an orbital outpost. Space radiation…”
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TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms
Published in Gates open research (2023)“…Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics…”
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Identification of RTS,S/AS01 vaccine-induced humoral biomarkers predictive of protection against controlled human malaria infection
Published in JCI insight (08-10-2024)“…BACKGROUNDThe mechanism(s) responsible for the efficacy of WHO-recommended malaria vaccine RTS,S/AS01 are not completely understood. We previously identified…”
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Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study
Published in Science (American Association for the Advancement of Science) (22-10-2021)“…Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2…”
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Titrationanalysis: A Tool for High-throughput Analysis of Binding Kinetics Data for Multiple Label-Free Platforms
Published in Biophysical journal (12-02-2021)Get full text
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TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms [version 2; peer review: 3 approved]
Published in Gates open research (01-06-2024)“…Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics…”
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