Search Results - "Gillian Douce"

An intact S-layer is advantageous to Clostridioides difficile within the host by Ormsby, Michael J, Vaz, Filipa, Kirk, Joseph A, Barwinska-Sendra, Anna, Hallam, Jennifer C, Lanzoni-Mangutchi, Paola, Cole, John, Chaudhuri, Roy R, Salgado, Paula S, Fagan, Robert P, Douce, Gillian R

“…Clostridioides difficile is responsible for substantial morbidity and mortality in antibiotically-treated, hospitalised, elderly patients, in which toxin…”
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LOV-based reporters for fluorescence imaging by Buckley, Anthony M, Petersen, Jan, Roe, Andrew J, Douce, Gillian R, Christie, John M

“…•Flavin-binding LOV domains have been engineered as green fluorescent reporters.•Several LOV-based FPs are available with different photophysical…”
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Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo by Nale, Janet Y, Spencer, Janice, Hargreaves, Katherine R, Buckley, Anthony M, Trzepiński, Przemysław, Douce, Gillian R, Clokie, Martha R J

“…The microbiome dysbiosis caused by antibiotic treatment has been associated with both susceptibility to and relapse of Clostridium difficile infection (CDI)…”
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Structure and assembly of the S-layer in C. difficile by Lanzoni-Mangutchi, Paola, Banerji, Oishik, Wilson, Jason, Barwinska-Sendra, Anna, Kirk, Joseph A., Vaz, Filipa, O’Beirne, Shauna, Baslé, Arnaud, El Omari, Kamel, Wagner, Armin, Fairweather, Neil F., Douce, Gillian R., Bullough, Per A., Fagan, Robert P., Salgado, Paula S.

“…Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers the cell surface and plays crucial roles in cell physiology. Here,…”
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The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile by Carter, Glen P, Douce, Gillian R, Govind, Revathi, Howarth, Pauline M, Mackin, Kate E, Spencer, Janice, Buckley, Anthony M, Antunes, Ana, Kotsanas, Despina, Jenkin, Grant A, Dupuy, Bruno, Rood, Julian I, Lyras, Dena

“…Nosocomial infections are increasingly being recognised as a major patient safety issue. The modern hospital environment and associated health care practices…”
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Enhancing a multi-purpose artificial urine for culture and gene expression studies of uropathogenic Escherichia coli strains by Rimbi, Patricia T, O'Boyle, Nicky, Douce, Gillian R, Pizza, Mariagrazia, Rosini, Roberto, Roe, Andrew J

“…The main objective of this study was to modify a recently reported multi-purpose artificial urine (MP-AU) for culture and gene expression studies of…”
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New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability by Kirk, Joseph A, Gebhart, Dana, Buckley, Anthony M, Lok, Stephen, Scholl, Dean, Douce, Gillian R, Govoni, Gregory R, Fagan, Robert P

“…There is a medical need for antibacterial agents that do not damage the resident gut microbiota or promote the spread of antibiotic resistance. We recently…”
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Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion by Connolly, James P. R., Slater, Sabrina L., O’Boyle, Nicky, Goldstone, Robert J., Crepin, Valerie F., Ruano-Gallego, David, Herzyk, Pawel, Smith, David G. E., Douce, Gillian R., Frankel, Gad, Roe, Andrew J.

“…Niche-adaptation of a bacterial pathogen hinges on the ability to recognize the complexity of signals from the environment and integrate that information with…”
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A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens by Wale, Kabo R, O'Boyle, Nicky, McHugh, Rebecca E, Serrano, Ester, Mark, David R, Douce, Gillian R, Connolly, James P R, Roe, Andrew J

“…The ability of the attaching and effacing pathogens enterohaemorrhagic Escherichia coli (EHEC) and Citrobacter rodentium to overcome colonisation resistance is…”
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Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection by McCaughey, Laura C., Ritchie, Neil. D., Douce, Gillian R., Evans, Thomas J., Walker, Daniel

“…Protein antibiotics, known as bacteriocins, are widely produced by bacteria for intraspecies competition. The potency and targeted action of bacteriocins…”
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Distinct ecological fitness factors coordinated by a conserved Escherichia coli regulator during systemic bloodstream infection by O'Boyle, Nicky, Douce, Gillian R, Farrell, Gillian, Rattray, Nicholas J W, Schembri, Mark A, Roe, Andrew J, Connolly, James P R

“…The ability of bacterial pathogens to adapt to host niches is driven by the carriage and regulation of genes that benefit pathogenic lifestyles. Genes that…”
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The duration of antibiotic treatment is associated with carriage of toxigenic and non-toxigenic strains of Clostridioides difficile in dogs by Albuquerque, Carolina, Pagnossin, Davide, Landsgaard, Kirsten, Simpson, Jessica, Brown, Derek, Irvine, June, Candlish, Denise, Ridyard, Alison E, Douce, Gillian, Millins, Caroline

“…Clostridioides difficile is a leading cause of human antibiotic-associated diarrhoeal disease globally. Zoonotic reservoirs of infection are increasingly…”
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Lighting Up Clostridium Difficile: Reporting Gene Expression Using Fluorescent Lov Domains by Buckley, Anthony M., Jukes, Caitlin, Candlish, Denise, Irvine, June J., Spencer, Janice, Fagan, Robert P., Roe, Andrew J., Christie, John M., Fairweather, Neil F., Douce, Gillian R.

“…The uses of fluorescent reporters derived from green fluorescent protein have proved invaluable for the visualisation of biological processes in bacteria grown…”
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Susceptibility of hamsters to Clostridium difficile isolates of differing toxinotype by Buckley, Anthony M, Spencer, Janice, Maclellan, Lindsay M, Candlish, Denise, Irvine, June J, Douce, Gillian R

“…Clostridium difficile is the most commonly associated cause of antibiotic associated disease (AAD), which caused ∼21,000 cases of AAD in 2011 in the U.K…”
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The post‐translational modification of the Clostridium difficile flagellin affects motility, cell surface properties and virulence by Faulds‐Pain, Alexandra, Twine, Susan M., Vinogradov, Evgeny, Strong, Philippa C. R., Dell, Anne, Buckley, Anthony M., Douce, Gillian R., Valiente, Esmeralda, Logan, Susan M., Wren, Brendan W.

“…Summary Clostridium difficile is a prominent nosocomial pathogen, proliferating and causing enteric disease in individuals with a compromised gut microflora…”
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The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7 by Beckham, Katherine S. H., Connolly, James P. R., Ritchie, Jennifer M., Wang, Dai, Gawthorne, Jayde A., Tahoun, Amin, Gally, David L., Burgess, Karl, Burchmore, Richard J., Smith, Brian O., Beatson, Scott A., Byron, Olwyn, Wolfe, Alan J., Douce, Gillian R., Roe, Andrew J.

“…Summary Classical studies have focused on the role that individual regulators play in controlling virulence gene expression. An emerging theme, however, is…”
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The metabolic enzyme AdhE controls the virulence of Escherichia coliO157:H7 by Beckham, Katherine SH, Connolly, James PR, Ritchie, Jennifer M, Wang, Dai, Gawthorne, Jayde A, Tahoun, Amin, Gally, David L, Burgess, Karl, Burchmore, Richard J, Smith, Brian O, Beatson, Scott A, Byron, Olwyn, Wolfe, Alan J, Douce, Gillian R, Roe, Andrew J

“…Classical studies have focused on the role that individual regulators play in controlling virulence gene expression. An emerging theme, however, is that…”
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Targeted Delivery of Narrow-Spectrum Protein Antibiotics to the Lower Gastrointestinal Tract in a Murine Model of Escherichia coli Colonization by Carpena, Nuria, Richards, Kerry, Bello Gonzalez, Teresita D J, Bravo-Blas, Alberto, Housden, Nicholas G, Gerasimidis, Konstantinos, Milling, Simon W F, Douce, Gillian, Malik, Danish J, Walker, Daniel

“…Bacteriocins are narrow-spectrum protein antibiotics that could potentially be used to engineer the human gut microbiota. However, technologies for targeted…”
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Author Correction: Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion by Connolly, James P. R., Slater, Sabrina L., O’Boyle, Nicky, Goldstone, Robert J., Crepin, Valerie F., Ruano-Gallego, David, Herzyk, Pawel, Smith, David G. E., Douce, Gillian R., Frankel, Gad, Roe, Andrew J.

“…The original version of this Article contained an error in the spelling of the author David Ruano-Gallego, which was incorrectly given as David R. Gallego…”
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Protective Efficacy Induced by Recombinant Clostridium difficile Toxin Fragments by Leuzzi, Rosanna, Spencer, Janice, Buckley, Anthony, Brettoni, Cecilia, Martinelli, Manuele, Tulli, Lorenza, Marchi, Sara, Luzzi, Enrico, Irvine, June, Candlish, Denise, Veggi, Daniele, Pansegrau, Werner, Fiaschi, Luigi, Savino, Silvana, Swennen, Erwin, Cakici, Osman, Oviedo-Orta, Ernesto, Giraldi, Monica, Baudner, Barbara, D'Urzo, Nunzia, Maione, Domenico, Soriani, Marco, Rappuoli, Rino, Pizza, Mariagrazia, Douce, Gillian R, Scarselli, Maria

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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