Clinical outcomes of dogs with transitional cell carcinoma receiving medical therapy, with and without partial cystectomy

The objective of this retrospective study was to evaluate the effects of surgery on outcome for dogs with naturally occurring urinary bladder transitional cell carcinoma. Forty-seven dogs met the inclusion criteria. Thirty-one dogs (Group A) were treated with partial cystectomy and adjunctive medica...

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Bibliographic Details
Published in:	Canadian veterinary journal Vol. 62; no. 2; pp. 133 - 140
Main Authors:	Bradbury, Marcus L, Mullin, Christine M, Gillian, Shaban D, Weisse, Chick, Bergman, Philip J, Morges, Michelle A, May, Lauren R, Vail, David M, Clifford, Craig A
Format:	Journal Article
Language:	English
Published:	Canada Canadian Veterinary Medical Association 01-02-2021
Subjects:	Animals Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - surgery Carcinoma, Transitional Cell - veterinary Cystectomy - veterinary Dog Diseases - drug therapy Dog Diseases - surgery Dogs Prospective Studies Retrospective Studies Scientific Treatment Outcome Urinary Bladder Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - surgery Urinary Bladder Neoplasms - veterinary
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Summary:	The objective of this retrospective study was to evaluate the effects of surgery on outcome for dogs with naturally occurring urinary bladder transitional cell carcinoma. Forty-seven dogs met the inclusion criteria. Thirty-one dogs (Group A) were treated with partial cystectomy and adjunctive medical therapy and 16 dogs (Group B) were treated with medical therapy alone. Overall survival was greater in dogs treated with partial cystectomy and adjunctive medical therapy (498 days for Group A 335 days for Group B, hazard ratio 2.5; 95% confidence interval: 1.1 to 5.7; = 0.026). Progression-free survival was not different between groups (85 days for Group A 83 days for Group B; = 0.663). No prognostic factors were identified for progression-free survival. Due to the many cases in Group A that were lost to follow-up, time-to-event survival analysis was performed. No significant difference in overall survival was noted, and no prognostic factors were identified in the time-to-event analysis. Prospective, randomized studies are needed to determine the role of partial cystectomy in the treatment of transitional cell carcinoma.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Dr. Bradbury’s current address is Coastal Empire Veterinary Surgery, 355 Stephenson Avenue, Savannah, Georgia 31405, USA.
ISSN:	0008-5286