Search Results - "Gillian, Martínez Donato"

A peptide derived from HSP60 reduces proinflammatory cytokines and soluble mediators: a therapeutic approach to inflammation by Domínguez-Horta, Maria Del Carmen, Serrano-Díaz, Anabel, Hernández-Cedeño, Mabel, Martínez-Donato, Gillian, Guillén-Nieto, Gerardo

“…Cytokines are secretion proteins that mediate and regulate immunity and inflammation. They are crucial in the progress of acute inflammatory diseases and…”
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Positive effects of Phycocyanobilin on gene expression in glutamate-induced excitotoxicity in SH-SY5Y cells and animal models of multiple sclerosis and cerebral ischemia by Gardón, Daniel Palenzuela, Cervantes-Llanos, Majel, Matamoros, Beatriz Piniella, Rodríguez, Hanlet Camacho, Tan, Chan-yuan, Marín –Prida, Javier, Falcón-Cama, Viviana, Pavón-Fuentes, Nancy, Lemus, Jessica Gómez, Ruiz, Laura de la Caridad Bakos, Argudin, Tamara Díaz, Donato, Gillian Martínez, Perera, Yasser, Yang, Ke, Pentón-Rol, Giselle

“…Oxidative stress has a predominant role in the pathogenesis of neurodegenerative diseases and therefore the modulation of genes and the identification of…”
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HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin by Yalena Amador-Caizares Gillian Martínez-Donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera

“…AIM:To analyze hepatitis C virus(HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-α(IFN-α)plus ribavirin…”
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A chimeric protein encompassing hepatitis C virus epitopes is able to elicit both humoral and cell-mediated immune responses in mice by Aguilar-Noriega, Daylen, Alvarez-Lajonchere, Liz, Brown, Emma, Santana, Felix Leonardo, Dubuisson, Jean, Wychowski, Czeslaw, Guerra, Ivis, Martínez-Donato, Gillian, Pérez, Angel, Amador-Cañizares, Yalena, Dueñas-Carrera, Santiago

“…Hepatitis C virus (HCV) infection is a worldwide health problem. Vaccines against this pathogen are not available and advances in this field are limited…”
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Clinical Evaluation of Terap C Vaccine in Combined Treatment with Interferon and Ribavirin in Patients with Hepatitis C by Zaily, Dorta Guridi, Marlen, Castellanos Fernandez, Santiago, Dueñas-Carrera, Gillian, Martínez Donato, Carmen, Valenzuela Silva, Zurina, Cinza Estevez, Enrique R., Arús Soler, Liz, Alvarez-Lajonchere, Lisset, González Fabián, Sacha, Lazo del Vallín, Elena, Ferrer Bataille

“…An estimated 170 million individuals worldwide are infected with the hepatitis C virus (HCV). Although treatment options using a combination of pegylated…”
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Ratio of HCV structural antigens in protein-based vaccine formulations is critical for functional immune response induction by Martínez-Donato, Gillian, Musacchio, Alexis, Alvarez-Lajonchere, Liz, Acosta-Rivero, Nelson, Amador, Yalena, Guerra, Ivis, Peña, Dilver, Pérez, Angel, Castro, Jorge, Puentes, Pedro, Soria, Yordanka, Cosme, Karelia, Sanchez, Jorge, Dueñas-Carrera, Santiago

“…HCV (hepatitis C virus) infection is among the leading causes of chronic liver disease, but currently there is no vaccine available. Data have accumulated…”
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Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis by Marín-Prida, Javier, Pavón-Fuentes, Nancy, Lagumersindez-Denis, Nielsen, Camacho-Rodríguez, Hanlet, García-Soca, Ana Margarita, Sarduy-Chávez, Rocío de la Caridad, Vieira, Érica Leandro Marciano, Carvalho-Tavares, Juliana, Falcón-Cama, Viviana, Fernández-Massó, Julio Raúl, Hernández-González, Ignacio, Martínez-Donato, Gillian, Guillén-Nieto, Gerardo, Pentón-Arias, Eduardo, Teixeira, Mauro Martins, Pentón-Rol, Giselle

“…Cytokines, demyelination and neuroaxonal degeneration in the central nervous system are pivotal elements implicated in the pathogenesis of multiple sclerosis…”
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The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome by Marín-Prida, Javier, Rodríguez-Ulloa, Arielis, Besada, Vladimir, Llopiz-Arzuaga, Alexey, Batista, Nathália Vieira, Hernández-González, Ignacio, Pavón-Fuentes, Nancy, Marciano Vieira, Érica Leandro, Falcón-Cama, Viviana, Acosta, Emilio F., Martínez-Donato, Gillian, Cervantes-Llanos, Majel, Lingfeng, Dai, González, Luis J., Fernández-Massó, Julio Raúl, Guillén-Nieto, Gerardo, Pentón-Arias, Eduardo, Amaral, Flávio Almeida, Teixeira, Mauro Martins, Pentón-Rol, Giselle

“…Introduction The antinociceptive and pharmacological activities of C-Phycocyanin (C-PC) and Phycocyanobilin (PCB) in the context of inflammatory arthritis…”
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CIGB-258, péptido inhibidor de la hiperinflamación en pacientes con COVID-19 by María del Carmen Domínguez Horta, Rafael Venegas Rodríguez, Gerardo Guillén Nieto, Gillian Martínez Donato, Mabel Hernández Cedeño, Mónica Bequet Romero, Rubén Peña Ruiz, Raúl Santana Sánchez, Luis Javier González, Ania Cabrales, Gabriel Padrón, Leticia Rosario Cruz, Idelsis Esquivel Moynelo

“…Introducción. El CIGB-258 es un péptido, cuyo mecanismo de acción se ha asociado con la inhibición de la inflamación. El presente trabajo tiene como objetivo…”
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CIGB-258 Exerts Potent Anti-Inflammatory Activity against Carboxymethyllysine-Induced Acute Inflammation in Hyperlipidemic Zebrafish via the Protection of Apolipoprotein A-I by Cho, Kyung-Hyun, Nam, Hyo-Seon, Kim, Ji-Eun, Na, Hye-Jee, Del Carmen Dominguez-Horta, Maria, Martinez-Donato, Gillian

“…Inflammation and atherosclerosis are intimately associated via the production of dysfunctional high-density lipoproteins (HDL) and modification of…”
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Synergistic Anti-Inflammatory Activity of Lipid-Free Apolipoprotein (apo) A-I and CIGB-258 in Acute-Phase Zebrafish via Stabilization of the apoA-I Structure to Enhance Anti-Glycation and Antioxidant Activities by Cho, Kyung-Hyun, Bahuguna, Ashutosh, Lee, Yunki, Lee, Sang Hyuk, Dominguez-Horta, Maria Del Carmen, Martinez-Donato, Gillian

“…CIGB-258, a 3 kDa peptide from heat shock protein 60, exhibits synergistic anti-inflammatory activity with apolipoprotein A-I (apoA-I) in reconstituted…”
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Induction of IgA and sustained deficiency of cell proliferative response in chronic hepatitis C by Amador-Cañizares, Yalena, Alvarez-Lajonchere, Liz, Guerra, Ivis, Rodríguez-Alonso, Ingrid, Martínez-Donato, Gillian, Triana, Julián, González-Horta, Eddy E, Pérez, Angel, Dueñas-Carrera, Santiago

“…In the present study, antibody and peripheral blood mononuclear cells (PBMC) proliferative responses against hepatitis C virus (HCV) antigens were evaluated in…”
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Multimeric HCV E2 protein obtained from Pichia pastoris cells induces a strong immune response in mice by MARTINEZ-DONATO, Gillian, CAPDESUNER, Yanelis, ACOSTA-RIVERO, Nelson, RODRIGUEZ, Armando, MORALES-GRILLO, Juan, MARTINEZ, Eduardo, GONZALEZ, Marleny, ALVAREZ-OBREGON, Julio C, DUENAS-CARRERA, Santiago

“…Production of immunogenic hepatitis C virus (HCV) envelope proteins will assist in the future development of preventive or therapeutics applications. Only…”
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Synergistic Anti-Inflammatory Activity of Apolipoprotein A-I and CIGB-258 in Reconstituted High-Density Lipoproteins (rHDL) against Acute Toxicity of Carboxymethyllysine in Zebrafish and Its Embryo by Cho, Kyung-Hyun, Kim, Ji-Eun, Kang, Dae-Jin, Dominguez-Horta, Maria Del Carmen, Martinez-Donato, Gillian

“…CIGB-258 is a 3 kDa altered peptide ligand from heat shock protein (HSP) 60 that exhibits anti-inflammatory activity against the acute toxicity of…”
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Enhancing Wound Healing and Anti-Inflammatory Effects by Combination of CIGB-258 and Apolipoprotein A-I against Carboxymethyllysine Toxicity in Zebrafish: Insights into Structural Stabilization and Antioxidant Properties by Cho, Kyung-Hyun, Lee, Yunki, Lee, Sang Hyuk, Kim, Ji-Eun, Bahuguna, Ashutosh, Dominguez-Horta, Maria Del Carmen, Martinez-Donato, Gillian

“…CIGB-258 is known to exert anti-inflammatory activity via structural stabilization of apolipoprotein A-I (apoA-I) and functional enhancement of high-density…”
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The treatment with Jusvinza reduces hyperinflammation and hypercoagulation in critical ill patients with COVID-19 by Rafael Venegas Rodríguez, Anabel Serrano Díaz, Rubén Peña Ruiz, Raúl Santana Sánchez, Aliusha Rittoles Navarro, Inti Grecesqui Cruz, Liam Manuel Pérez Aguilera, Anadys Segura Fernández, Mabel Hernández-Cedeño, Leticia Rosario Cruz, Deyli Chacón Montano, Gillian Martínez-Donato, Gerardo Guillén-Nieto, María del Carmen Domínguez Horta

“…Introduction: Infection with SARS-CoV-2 induces a prothrombotic state in patients, by the combination of hyperinflammatory response and hypoxia. In Cuba, the…”
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The treatment with Jusvinza reduces hyperinflammation and hypercoagulation in critical ill patients with COVID-19 by Rafael Venegas Rodríguez, Anabel Serrano Díaz, Rubén Peña Ruiz, Raúl Santana Sánchez, Aliusha Rittoles Navarro, Inti Grecesqui Cruz, Liam Manuel Pérez Aguilera, Anadys Segura Fernández, Mabel Hernández-Cedeño, Leticia Rosario Cruz, Deyli Chacón Montano, Gillian Martínez-Donato, Gerardo Guillén-Nieto, María del Carmen Domínguez Horta

“…Introduction: Infection with SARS-CoV-2 induces a prothrombotic state in patients, by the combination of hyperinflammatory response and hypoxia. In Cuba, the…”
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CIGB-258 immunomodulatory peptide for the treatment of critical and severe COVID-19 patients by Rafael Venegas Rodríguez, Rubén Peña Ruiz, Raúl Santana Sánchez, Mónica Bequet-Romero, Mabel Hernández-Cedeño, Beatriz Santiesteban Licea, Ariana García, Pedro Rafel Aroche de Dios, Daniela Oliva Pérez, Leticia Rosario Cruz, Idelsis Esquivel Moynelo, Maura García Sánchez, Gillian Martínez-Donato, Gerardo Guillén-Nieto, María del Carmen Domínguez Horta

“…Introduction: CIGB-258 is an immunomodulatory peptide with anti-inflammatory properties. Objectives: To establish the therapeutic schedule with CIGB-258…”
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Clinical Evaluation of Terap C Vaccine Candidate in Combined Treatment with Interferon and Ribavirin in Patients with Hepatitis C by Guridi, Zaily Dorta, Castellanos Fernandez, Marlen I, Dueñas-Carrera, Santiago, Donato, Gillian Martínez, Silva, Carmen Valenzuela, Estevez, Zurina Cinza, Arús Soler, Enrique R, Alvarez-Lajonchere, Liz, Fabián, Lisset González, del Vallín, Sacha Lazo, Ferrer, Elena

“…Abstract Background An estimated 170 million individuals worldwide are infected with the hepatitis C virus (HCV). Although treatment options using a…”
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Protective cellular immune response against hepatitis C virus elicited by chimeric protein formulations in BALB/c mice by Olivera, Santa, Perez, Angel, Falcon, Viviana, Urquiza, Dioslaida, Pichardo, Dagmara, Martinez-Donato, Gillian

“…The eradication of hepatitis C virus (HCV) infection is a public health priority. Despite the efficiency of treatment with direct-acting antivirals, the high…”
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