Search Results - "Gillette, J R"

Social monogamy in a territorial salamander by Gillette, Jennifer R., Jaeger, Robert G., Peterson, Megan G.

“…Social monogamy, which does not necessarily imply mating or genetic monogamy, is important in the formation of male–female pair associations. We operationally…”
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Immunological studies on the mechanism of halothane-induced hepatotoxicity: immunohistochemical evidence of trifluoroacetylated hepatocytes by Satoh, H, Fukuda, Y, Anderson, D K, Ferrans, V J, Gillette, J R, Pohl, L R

“…The fulminant hepatotoxicity caused by halothane has been thought to have an immunological basis because this toxicity occurs most often after repeated…”
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Glutathione conjugates of 2-bromohydroquinone are nephrotoxic by Monks, T J, Lau, S S, Highet, R J, Gillette, J R

“…Incubation of either o-bromophenol or 2-bromohydroquinone with rat liver microsomes and 0.25 mM 35S-glutathione (GSH) gave rise to several isomeric 35S-GSH…”
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Theoretical kinetics of sequential metabolism in vitro. Study of the formation of 16 alpha-hydroxyandrostenedione from testosterone by purified rat P450 2C11 by Sugiyama, K, Nagata, K, Gillette, J R, Darbyshire, J F

“…P450 2C11 from rat liver is known to metabolize testosterone to 2 alpha-, 16 alpha-, and 6 beta-hydroxytestosterone, and to androstenedione and 16…”
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Isozymes of cytochrome P-450 that metabolize naphthalene in liver and lung of untreated mice by Nagata, K, Martin, B M, Gillette, J R, Sasame, H A

“…Four isozymes, designated P-450m50a, P-450m50b, P-450m51a, and P-450m51b, have been isolated from liver microsomes of untreated male CD-1 mice…”
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An unusual metabolite of testosterone. 17 beta-Hydroxy-4,6-androstadiene-3-one by Nagata, K, Liberato, D J, Gillette, J R, Sasame, H A

“…A testosterone metabolite, 17 beta-hydroxy-4,6-androstadiene-3-one, possessing an absorbance maximum at 284 nm, was formed during incubation of testosterone…”
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The Pennsylvania State University College of Medicine 1991 Bernard B. Brodie Lecture. Insights into deuterium isotope effects on the metabolism of steroid hormones and foreign compounds by cytochrome P-450 enzymes by Gillette, J R

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Immunochemical evidence of trifluoroacetylated cytochrome P-450 in the liver of halothane-treated rats by Satoh, H, Gillette, J R, Davies, H W, Schulick, R D, Pohl, L R

“…Four hours after the administration of halothane to phenobarbital-pretreated rats, subcellular fractions of liver were isolated and the proteins in the…”
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Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione by Mitchell, J R, Jollow, D J, Potter, W Z, Gillette, J R, Brodie, B B

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Pharmacokinetic procedures for the estimation of organ clearances for the formation of short-lived metabolites. Acetaminophen-induced glutathione depletion in hamster liver by Chen, R, Gillette, J R

“…Several approaches have been developed to estimate in vivo the intrinsic clearances of enzymes that catalyze the formation of chemically reactive metabolites…”
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Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism by Mitchell, J R, Jollow, D J, Potter, W Z, Davis, D C, Gillette, J R, Brodie, B B

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Identification of 2-bromohydroquinone as a metabolite of bromobenzene and o-bromophenol: implications for bromobenzene-induced nephrotoxicity by Lau, S S, Monks, T J, Gillette, J R

“…2-Bromohydroquinone was identified as a metabolite of both bromobenzene and o-bromophenol in the rat in vivo and in vitro. Identification was based on…”
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Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo by Jollow, D J, Mitchell, J R, Potter, W Z, Davis, D C, Gillette, J R, Brodie, B B

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Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin by Pang, K S, Gillette, J R

“…Both [14C]phenacetin and [3H]acetaminophen in tracer concentrations were perfused simultaneously once through the rat liver preparation at a constant perfusate…”
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Diffusion of reactive metabolites out of hepatocytes: studies with bromobenzene by Monks, T J, Lau, S S, Gillette, J R

“…We have developed a simple experimental technique which allows the determination of the relative rates of intracellular inactivation of chemically reactive…”
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Multiple reactive metabolites derived from bromobenzene by Lau, S S, Monks, T J, Gillette, J R

“…It has recently been shown that bromobenzene is converted to multiple reactive metabolites. However, the nature of these reactive metabolites is unclear. In…”
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The formation of glutathione conjugate derived from propranolol by Sasame, H A, Liberato, D J, Gillette, J R

“…Mixed function oxidases in liver microsomes from 3-methylcholanthrene-pretreated guinea pigs converted S-propranolol to 4-hydroxypropranolol,…”
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Theoretical studies on cytochrome P-450 mediated hydroxylation: a predictive model for hydrogen atom abstractions by Korzekwa, Kenneth R, Jones, Jeffery P, Gillette, James R

“…The semiempirical quantum chemical method, AM1, was used to develop a predictive model for cytochrome P-450 hydrogen abstraction reactions. Initially, a…”
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3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen by Hinson, J A, Pohl, L R, Monks, T J, Gillette, J R, Guengerich, F P

“…3-Hydroxyacetaminophen has been isolated and identified as a microsomal metabolite of acetaminophen. Analysis of the metabolite by gas chromatography-mass…”
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Role of detoxifying enzymes in bromobenzene-induced liver necrosis by Zampaglione, N, Jollow, D J, Mitchell, J R, Stripp, B, Hamrick, M, Gillette, J R

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