The effect of hip replacement on prescribing of NSAIDs, ulcer healing drugs and hospitalization-a matched cohort study

Purpose To assess the impact of total hip replacement on prescribing of non‐steroidal anti‐inflammatory drugs (NSAIDs), ulcer healing drugs (UHDs) and hospitalization. Methods Observational matched cohort study. Results There were 282 subjects in the hip replacement cohort and 1691 in the comparator...

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Bibliographic Details
Published in:	Pharmacoepidemiology and drug safety Vol. 8; no. 6; pp. 423 - 431
Main Authors:	Davey, Peter G., McMahon, Alex D., Barbone, Fabio, Gillespie, William G., Rizvi, K. A., MacDonald, Thomas M.
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-10-1999
Subjects:	arthritis gastrointestinal haemorrhage hip replacement non steroidal anti-inflammatory drugs (NSAIDs) ulcer healing drugs
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Summary:	Purpose To assess the impact of total hip replacement on prescribing of non‐steroidal anti‐inflammatory drugs (NSAIDs), ulcer healing drugs (UHDs) and hospitalization. Methods Observational matched cohort study. Results There were 282 subjects in the hip replacement cohort and 1691 in the comparator cohort. Dispensing of NSAIDs fell from 89% to 57% after hip replacement but increased from 36% to 39% in comparators. Dispensing of UHDs fell from 33% to 30% after hip replacement but increased from 16% to 23% in the comparators. Hospitalization for upper gastrointestinal events fell from 2.5% to 1.8% after hip replacement but increased from 1.4% to 1.7% in comparators. Hospitalization for other causes increased from 32% to 42% after hip replacement compared with 25% to 28% in comparators. Conclusions Hip replacement is associated with reduced prescribing of NSAIDs and UHDs. However, any effect on GI admissions will be small compared with increased hospitalization for other causes. Copyright © 1999 John Wiley & Sons, Ltd.
Bibliography:	ark:/67375/WNG-Z6D3XHXD-C ArticleID:PDS447 istex:FDD324929AA02CA7DB0F7A68ACFDE6A22560B28B Dundee Teaching Hospitals Research and Development Committee This study was supported by a grant from the Dundee Teaching Hospitals Research and Development Committee. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1053-8569 1099-1557
DOI:	10.1002/(SICI)1099-1557(199910/11)8:6<423::AID-PDS447>3.0.CO;2-T