Search Results - "Gillespie, Virginia"

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection by Rathnasinghe, Raveen, Strohmeier, Shirin, Amanat, Fatima, Gillespie, Virginia L., Krammer, Florian, García-Sastre, Adolfo, Coughlan, Lynda, Schotsaert, Michael, Uccellini, Melissa B.

“…Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide pandemic with high morbidity and mortality. Development of animal models…”
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Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death by Ang, Rosalind L., Chan, Mark, Legarda, Diana, Sundberg, John P., Sun, Shao-Cong, Gillespie, Virginia L., Chun, Nicholas, Heeger, Peter S., Xiong, Huabao, Lira, Sergio A., Ting, Adrian T.

“…SHARPIN, together with RNF31/HOIP and RBCK1/HOIL1, form the linear ubiquitin chain assembly complex (LUBAC) E3 ligase that catalyzes M1-linked…”
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A single-shot adenoviral vaccine provides hemagglutinin stalk-mediated protection against heterosubtypic influenza challenge in mice by Bliss, Carly M., Freyn, Alec W., Caniels, Tom G., Leyva-Grado, Victor H., Nachbagauer, Raffael, Sun, Weina, Tan, Gene S., Gillespie, Virginia L., McMahon, Meagan, Krammer, Florian, Hill, Adrian V.S., Palese, Peter, Coughlan, Lynda

“…Conventional influenza vaccines fail to confer broad protection against diverse influenza A viruses with pandemic potential. Efforts to develop a universal…”
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Treatment of Intestinal Inflammation With Epicutaneous Immunotherapy Requires TGF-β and IL-10 but Not Foxp3 + Tregs by Chen, Xin, Berin, M Cecilia, Gillespie, Virginia L, Sampson, Hugh A, Dunkin, David

“…Inflammatory bowel disease (IBD) involves an increase in T effector cells in the intestines that disrupts the normal balance with T regulatory cells (Tregs). A…”
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Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera by Rathnasinghe, Raveen, Jangra, Sonia, Ye, Chengjin, Cupic, Anastasija, Singh, Gagandeep, Martínez-Romero, Carles, Mulder, Lubbertus C. F., Kehrer, Thomas, Yildiz, Soner, Choi, Angela, Yeung, Stephen T., Mena, Ignacio, Gillespie, Virginia, De Vrieze, Jana, Aslam, Sadaf, Stadlbauer, Daniel, Meekins, David A., McDowell, Chester D., Balaraman, Velmurugan, Corley, Michael J., Richt, Juergen A., De Geest, Bruno G., Miorin, Lisa, Krammer, Florian, Martinez-Sobrido, Luis, Simon, Viviana, García-Sastre, Adolfo, Schotsaert, Michael

“…Due to differences in human and murine angiotensin converting enzyme 2 (ACE-2) receptor, initially available SARS-CoV-2 isolates could not infect mice. Here we…”
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Pre‐clinical development of a cryopreservable megakaryocytic cell product capable of sustained platelet production in mice by Patel, Ami, Clementelli, Cara Marie, Jarocha, Danuta, Mosoyan, Gohar, Else, Cindy, Kintali, Manisha, Fong, Helen, Tong, Jay, Gordon, Ronald, Gillespie, Virginia, Keyzner, Alla, Poncz, Mortimer, Hoffman, Ronald, Iancu‐Rubin, Camelia

“…BACKGROUND Platelet (PLT) transfusions are the most effective treatments for patients with thrombocytopenia. The growing demand for PLT transfusion products is…”
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Lifetime Evaluation of Left Ventricular Structure and Function in Male C57BL/6J Mice after Gamma and Space-Type Radiation Exposure by Brojakowska, Agnieszka, Jackson, Cedric J, Bisserier, Malik, Khlgatian, Mary K, Grano, Cynthia, Blattnig, Steve R, Zhang, Shihong, Fish, Kenneth M, Chepurko, Vadim, Chepurko, Elena, Gillespie, Virginia, Dai, Ying, Lee, Brooke, Garikipati, Venkata Naga Srikanth, Hadri, Lahouaria, Kishore, Raj, Goukassian, David A

“…The lifetime effects of space irradiation (IR) on left ventricular (LV) function are unknown. The cardiac effects induced by space-type IR, specifically 5-ion…”
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Germline deletion of Krüppel-like factor 14 does not increase risk of diet induced metabolic syndrome in male C57BL/6 mice by Argmann, Carmen A., Violante, Sara, Dodatko, Tetyana, Amaro, Mariana P., Hagen, Jacob, Gillespie, Virginia L., Buettner, Christoph, Schadt, Eric E., Houten, Sander M.

“…The transcription factor Krüppel-like factor 14 (KLF14) has been associated with type 2 diabetes and high-density lipoprotein-cholesterol (HDL-C) through…”
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Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection by Leyva-Grado, Victor H, Ermler, Megan E, Schotsaert, Michael, Gonzalez, Ma G, Gillespie, Virginia, Lim, Jean K, García-Sastre, Adolfo

“…An exacerbated immune response is one of the main causes of influenza-induced lung damage during infection. The molecular mechanisms regulating the fate of the…”
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Lifetime evaluation of left ventricular structure and function in male ApoE null mice after gamma and space-type radiation exposure by Brojakowska, Agnieszka, Jackson, Cedric J, Bisserier, Malik, Khlgatian, Mary K, Jagana, Vineeta, Eskandari, Abrisham, Grano, Cynthia, Blattnig, Steve R, Zhang, Shihong, Fish, Kenneth M, Chepurko, Vadim, Chepurko, Elena, Gillespie, Virginia, Dai, Ying, Kumar Rai, Amit, Garikipati, Venkata Naga Srikanth, Hadri, Lahouaria, Kishore, Raj, Goukassian, David A

“…The space radiation (IR) environment contains high charge and energy (HZE) nuclei emitted from galactic cosmic rays with the ability to overcome current…”
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The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo by Hamard, Pierre-Jacques, Barthelery, Nicolas, Hogstad, Brandon, Mungamuri, Sathish Kumar, Tonnessen, Crystal A, Carvajal, Luis A, Senturk, Emir, Gillespie, Virginia, Aaronson, Stuart A, Merad, Miriam, Manfredi, James J

“…The p53 tumor suppressor is a transcription factor that mediates varied cellular responses. The C terminus of p53 is subjected to multiple and diverse…”
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Morbid Obesity Resulting from Inactivation of the Ciliary Protein CEP19 in Humans and Mice by Shalata, Adel, Ramirez, Maria C., Desnick, Robert J., Priedigkeit, Nolan, Buettner, Christoph, Lindtner, Claudia, Mahroum, Mohammed, Abdul-Ghani, Muhammad, Dong, Feng, Arar, Nazik, Camacho-Vanegas, Olga, Zhang, Rui, Camacho, Sandra C., Chen, Ying, Ibdah, Mwafaq, DeFronzo, Ralph, Gillespie, Virginia, Kelley, Kevin, Dynlacht, Brian D., Kim, Sehyun, Glucksman, Marc J., Borochowitz, Zvi U., Martignetti, John A.

“…Obesity is a major public health concern, and complementary research strategies have been directed toward the identification of the underlying causative gene…”
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Inflammatory Responses with Left Ventricular Compromise after Induction of Myocardial Infarcts in Sheep (Ovis aries) by Gordon, Hylton P, Katz, Michael G, Fazal, Shahood, Gillespie, Virginia L, Fargnoli, Anthony S, Gubara, Sarah M, Madjarova, Sophia J, Cohen, Jonathan A

“…Ischemic myocardial disease is a major cause of death among humans worldwide; it results in scarring and pallor of the myocardium and triggers an inflammatory…”
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Effects of Multimodal Analgesia with Low-Dose Buprenorphine and Meloxicam on Fecal Glucocorticoid Metabolites after Surgery in New Zealand White Rabbits (Oryctolagus cuniculus) by Goldschlager, Gregg B, Gillespie, Virginia L, Palme, Rupert, Baxter, Mark G

“…Despite the increasing use of rabbits as companion animals and models for biomedical research, rabbits have not been extensively studied to identify an…”
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Scar Size and Other Parameters for Tracking Left Ventricular Dysfunction after Induction of Myocardial Infarcts in Sheep (Ovis aries) by Gordon, Hylton P, Katz, Michael G, Fargnoli, Anthony S, Gillespie, Virginia L, Hajjar, Roger J, Bridges, Charles R

“…In humans, cardiovascular disease (CVD) is the most frequent cause of death worldwide. Myocardial infarction (MI) is a leading cause of heart failure due to…”
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Butanol Purified Food Allergy Herbal Formula-2 Has an Immunomodulating Effect ex-vivo in Pediatric Crohn's Disease Subjects by Chen, Xin, Lai, Joanne, Song, Ying, Yang, Nan, Gnjatic, Sacha, Gillespie, Virginia, Hahn, William, Chefitz, Ezra, Pittman, Nanci, Jossen, Jacqueline, Benkov, Keith, Dubinsky, Marla, Li, Xiu-Min, Dunkin, David

“…TNF-α has a major role in the pathogenesis of Crohn's disease (CD). In contrast, GM-CSF may be beneficial for its anti-inflammatory role in a subset of…”
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Substitutions T200A and E227A in the Hemagglutinin of Pandemic 2009 Influenza A Virus Increase Lethality but Decrease Transmission by Martínez-Romero, Carles, de Vries, Erik, Belicha-Villanueva, Alan, Mena, Ignacio, Tscherne, Donna M., Gillespie, Virginia L., Albrecht, Randy A., de Haan, Cornelis A. M., García-Sastre, Adolfo

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Histological Examination of Respiratory Tissues of Dolphins and Porpoises Subjected to Postmortem Blast Exposure by Fetherston, Thomas, Russell, Stephen, Gillespie, Virginia, Reidenberg, Joy

“…Exposure to explosions often causes morbidity as waves of over‐pressure and under‐pressure shear interstitial tissue and cause traumatic damage including…”
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Navtemadlin (KRT-232), a Small Molecule MDM2 Inhibitor, Is More Effective Than Decitabine Against Myeloproliferative Neoplasm-Blast Phase in a Patient-Derived Xenograft Model by Wang, Xiaoli, Hu, Cing Siang, Gillespie, Virginia, Krejsa, Cecile Marie, Hoffman, Ronald

“…Patients with myeloproliferative neoplasm-blast phase (MPN-BP) have a particularly dismal prognosis with a median survival of less than 6 months with currently…”
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Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system by Rosselot, Carolina, Li, Yansui, Wang, Peng, Alvarsson, Alexandra, Beliard, Kara, Lu, Geming, Kang, Randy, Li, Rosemary, Liu, Hongtao, Gillespie, Virginia, Tzavaras, Nikolaos, Kumar, Kunal, DeVita, Robert J, Stewart, Andrew F, Stanley, Sarah A, Garcia-Ocaña, Adolfo

“…Five hundred thirty-seven million people globally suffer from diabetes. Insulin-producing β cells are reduced in number in most people with diabetes, but most…”
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