Search Results - "Gillespie, H"

Improving outcomes for multidrug-resistant TB: the role of integrated systems by Gillespie, S. H.

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The role of moxifloxacin in tuberculosis therapy by Gillespie, Stephen H

“…Tuberculosis (TB) remains a global threat with more than 9 million new infections. Treatment remains difficult and there has been no change in the duration of…”
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Routine use of microbial whole genome sequencing in diagnostic and public health microbiology by Köser, Claudio U, Ellington, Matthew J, Cartwright, Edward J P, Gillespie, Stephen H, Brown, Nicholas M, Farrington, Mark, Holden, Matthew T G, Dougan, Gordon, Bentley, Stephen D, Parkhill, Julian, Peacock, Sharon J

“…According to the current diagnostic paradigm for Mycobacterium tuberculosis complex (MTBC), clinical samples (usually sputum) are first analysed using smear…”
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Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis by Gillespie, Stephen H, Crook, Angela M, McHugh, Timothy D, Mendel, Carl M, Meredith, Sarah K, Murray, Stephen R, Pappas, Frances, Phillips, Patrick P.J, Nunn, Andrew J

“…One approach to improving tuberculosis therapy is to shorten the duration from 6 months to 4 months. In this trial in over 1900 patients with smear-positive…”
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Tuberculosis Treatment Monitoring and Outcome Measures: New Interest and New Strategies by Heyckendorf, Jan, Georghiou, Sophia B, Frahm, Nicole, Heinrich, Norbert, Kontsevaya, Irina, Reimann, Maja, Holtzman, David, Imperial, Marjorie, Cirillo, Daniela M, Gillespie, Stephen H, Ruhwald, Morten

“…Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a global public health threat. A significant challenge for TB control…”
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A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses by Svensson, Robin J., Aarnoutse, Rob E., Diacon, Andreas H., Dawson, Rodney, Gillespie, Stephen H., Boeree, Martin J., Simonsson, Ulrika S.H.

“…Accumulating evidence suggests that increasing doses of rifampicin may shorten tuberculosis treatment. The PanACEA HIGHRIF1 trial assessed safety,…”
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Red Blood Cell Contribution to Hemostasis by Gillespie, Andrea H, Doctor, Allan

“…Red Blood Cells (RBCs) have been increasingly recognized to play important roles in hemostasis and the mechanisms by which they do so continue to be…”
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New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects by Zumla, Alimuddin I, Prof, Gillespie, Stephen H, Prof, Hoelscher, Michael, Prof, Philips, Patrick P J, PhD, Cole, Stewart T, Prof, Abubakar, Ibrahim, Prof, McHugh, Timothy D, Prof, Schito, Marco, PhD, Maeurer, Markus, Prof, Nunn, Andrew J, Prof

“…Summary About 1·3 million people died of tuberculosis in 2012, despite availability of effective drug treatment. Barriers to improvements in outcomes include…”
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Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice by Bitto, Alessandro, Ito, Takashi K, Pineda, Victor V, LeTexier, Nicolas J, Huang, Heather Z, Sutlief, Elissa, Tung, Herman, Vizzini, Nicholas, Chen, Belle, Smith, Kaleb, Meza, Daniel, Yajima, Masanao, Beyer, Richard P, Kerr, Kathleen F, Davis, Daniel J, Gillespie, Catherine H, Snyder, Jessica M, Treuting, Piper M, Kaeberlein, Matt

“…The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions…”
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High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial by Boeree, Martin J, PhD, Heinrich, Norbert, MD, Aarnoutse, Rob, PhD, Diacon, Andreas H, PhD, Dawson, Rodney, PhD, Rehal, Sunita, MSc, Kibiki, Gibson S, Prof, Churchyard, Gavin, Prof, Sanne, Ian, FRCP, Ntinginya, Nyanda E, MD, Minja, Lilian T, MD, Hunt, Robert D, BSc, Charalambous, Salome, PhD, Hanekom, Madeleine, PhD, Semvua, Hadija H, PhD, Mpagama, Stellah G, PhD, Manyama, Christina, MD, Mtafya, Bariki, MSc, Reither, Klaus, MD, Wallis, Robert S, Prof, Venter, Amour, NatDipMicr, Narunsky, Kim, MD, Mekota, Anka, PhD, Henne, Sonja, MSc, Colbers, Angela, PhD, van Balen, Georgette Plemper, PhD, Gillespie, Stephen H, Prof, Phillips, Patrick P J, PhD, Hoelscher, Michael, Prof

“…Summary Background Tuberculosis is the world's leading infectious disease killer. We aimed to identify shorter, safer drug regimens for the treatment of…”
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Genetic Drift in an Infinite Population: The Pseudohitchhiking Model by Gillespie, John H

“…Selected substitutions at one locus can induce stochastic dynamics that resemble genetic drift at a closely linked neutral locus. The pseudohitchhiking model…”
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A simple label-free method reveals bacterial growth dynamics and antibiotic action in real-time by Hammond, Robert J. H., Falconer, Kerry, Powell, Thomas, Bowness, Ruth, Gillespie, Stephen H.

“…Understanding the response of bacteria to environmental stress is hampered by the relative insensitivity of methods to detect growth. This means studies of…”
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Why Do We Use 600 mg of Rifampicin in Tuberculosis Treatment? by van Ingen, Jakko, Aarnoutse, Rob E., Donald, Peter R., Diacon, Andreas H., Dawson, Rodney, Plemper van Balen, Georgette, Gillespie, Stephen H., Boeree, Martin J.

“…The 600mg once daily dose of rifampicin in tuberculosis treatment was based on historical arguments concerning pharmacokinetics, toxicity and cost, that have…”
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Perspective for Precision Medicine for Tuberculosis by Lange, Christoph, Aarnoutse, Rob, Chesov, Dumitru, van Crevel, Reinout, Gillespie, Stephen H, Grobbel, Hans-Peter, Kalsdorf, Barbara, Kontsevaya, Irina, van Laarhoven, Arjan, Nishiguchi, Tomoki, Mandalakas, Anna, Merker, Matthias, Niemann, Stefan, Köhler, Niklas, Heyckendorf, Jan, Reimann, Maja, Ruhwald, Morten, Sanchez-Carballo, Patricia, Schwudke, Dominik, Waldow, Franziska, DiNardo, Andrew R

“…Tuberculosis is a bacterial infectious disease that is mainly transmitted from human to human via infectious aerosols. Currently, tuberculosis is the leading…”
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Factors Related to Burnout Among Perinatal Home Visiting Nurses by Greene, Madelyne Z., Gillespie, Kate H.

“…Risks for burnout among nurses have been understudied in public and community health settings. This qualitative descriptive study aimed to describe the…”
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Bacterial etiology of urinary tract infections in patients treated at Kenyan health facilities and their resistance towards commonly used antibiotics by Kiiru, Susan, Maina, John, Katana, Japhet, Mwaniki, John, Asiimwe, Benon B, Mshana, Stephen E, Keenan, Katherine, Gillespie, Stephen H, Stelling, John, Holden, Matthew T G, Kiiru, John

“…Evidence-based empirical antibiotic prescribing requires knowledge of local antimicrobial resistance patterns. The spectrum of pathogens and their…”
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Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use by Keenan, Katherine, Papathomas, Michail, Mshana, Stephen E., Asiimwe, Benon, Kiiru, John, Lynch, Andy G., Kesby, Mike, Neema, Stella, Mwanga, Joseph R., Mushi, Martha F., Jing, Wei, Green, Dominique L., Olamijuwon, Emmanuel, Zhang, Qing, Sippy, Rachel, Fredricks, Kathryn J., Gillespie, Stephen H., Sabiiti, Wilber, Bazira, Joel, Sloan, Derek J., Mmbaga, Blandina T., Kibiki, Gibson, Aanensen, David, Stelling, John, Smith, V. Anne, Sandeman, Alison, Holden, Matthew T. G.

“…The global health crisis of antibacterial resistance (ABR) poses a particular threat in low-resource settings like East Africa. Interventions for ABR typically…”
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Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder by Ferguson, Bradley J, Marler, Sarah, Altstein, Lily L, Lee, Evon Batey, Mazurek, Micah O, McLaughlin, Aaron, Macklin, Eric A, McDonnell, Erin, Davis, Daniel J, Belenchia, Anthony M, Gillespie, Catherine H, Peterson, Catherine A, Bauman, Margaret L, Margolis, Kara Gross, Veenstra-VanderWeele, Jeremy, Beversdorf, David Q

“…Highlights • Lower gastrointestinal tract symptoms relate to cortisol response to stress in ASD. • Lower gastrointestinal tract symptoms not related to…”
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Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study by Tweed, Conor Duncan, Wills, Genevieve Helen, Crook, Angela M, Dawson, Rodney, Diacon, Andreas H, Louw, Cheryl E, McHugh, Timothy D, Mendel, Carl, Meredith, Sarah, Mohapi, Lerato, Murphy, Michael E, Murray, Stephen, Murthy, Sara, Nunn, Andrew J, Phillips, Patrick P J, Singh, Kasha, Spigelman, M, Gillespie, S H

“…Drug-induced liver injury (DILI) is a common complication of tuberculosis treatment. We utilised data from the REMoxTB clinical trial to describe the incidence…”
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Evolution of drug resistance in Mycobacterium tuberculosis: Clinical and molecular perspective by GILLESPIE, Stephen H

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