Search Results - "Gill, Ryan"

Granulomatous hepatitis, a mystery solved by Bahceci, Dorukhan, Hameed, Bilal, Gill, Ryan M.

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Directed Evolution of CRISPR/Cas Systems for Precise Gene Editing by Liu, Rongming, Liang, Liya, Freed, Emily F., Gill, Ryan T.

“…CRISPR technology is a universal tool for genome engineering that has revolutionized biotechnology. Recently identified unique CRISPR/Cas systems, as well as…”
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Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering by Garst, Andrew D, Bassalo, Marcelo C, Pines, Gur, Lynch, Sean A, Halweg-Edwards, Andrea L, Liu, Rongming, Liang, Liya, Wang, Zhiwen, Zeitoun, Ramsey, Alexander, William G, Gill, Ryan T

“…An approach called CREATE enables multiplex genome engineering, protein engineering and mapping of mutations in bacterial and yeast cells. Improvements in DNA…”
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Engineering global regulators for enhanced tolerance to multiple inhibitors by CRISPR‐enabled trackable genome engineering by Song, Xin, Zheng, Yangyang, Li, Shuting, Choudhury, Alaksh, Liu, Xunli, Chen, Tao, Gill, Ryan T., Wang, Zhiwen

“…Strain engineering for industrial production requires the improvement of tolerance to multiple unfavorable conditions. Here, we report global regulator…”
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Organic acid toxicity, tolerance, and production in Escherichia coli biorefining applications by Warnecke, Tanya, Gill, Ryan T

“…Organic acids are valuable platform chemicals for future biorefining applications. Such applications involve the conversion of low-cost renewable resources to…”
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Among Patients With Nonalcoholic Fatty Liver Disease, Modest Alcohol Use Is Associated With Less Improvement in Histologic Steatosis and Steatohepatitis by Ajmera, Veeral, Belt, Patricia, Wilson, Laura A., Gill, Ryan M., Loomba, Rohit, Kleiner, David E., Neuschwander-Tetri, Brent A., Terrault, Norah

“…Cross-sectional studies of patients with nonalcoholic fatty liver disease (NAFLD) have reported a lower prevalence of severe disease among modest drinkers…”
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Directed evolution and synthetic biology applications to microbial systems by Bassalo, Marcelo C, Liu, Rongming, Gill, Ryan T

“…Graphical abstract…”
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A comparison of per sample global scaling and per gene normalization methods for differential expression analysis of RNA-seq data by Li, Xiaohong, Brock, Guy N, Rouchka, Eric C, Cooper, Nigel G F, Wu, Dongfeng, O'Toole, Timothy E, Gill, Ryan S, Eteleeb, Abdallah M, O'Brien, Liz, Rai, Shesh N

“…Normalization is an essential step with considerable impact on high-throughput RNA sequencing (RNA-seq) data analysis. Although there are numerous methods for…”
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A statistical framework for differential network analysis from microarray data by Gill, Ryan, Datta, Somnath, Datta, Susmita

“…It has been long well known that genes do not act alone; rather groups of genes act in consort during a biological process. Consequently, the expression levels…”
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Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling by Chen, Bin, Wei, Wei, Ma, Li, Yang, Bin, Gill, Ryan M, Chua, Mei-Sze, Butte, Atul J, So, Samuel

“…Background & Aims Drug repositioning offers a shorter approval process than new drug development. We therefore searched large public datasets of drug-induced…”
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Combinatorial pathway engineering using type I‐E CRISPR interference by Tarasava, Katia, Liu, Rongming, Garst, Andrew, Gill, Ryan T.

“…ABSTRACT Optimization of metabolic flux is a difficult and time‐consuming process that often involves changing the expression levels of multiple genes…”
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Deep mutational scanning reveals the molecular determinants of RNA polymerase-mediated adaptation and tradeoffs by Choudhury, Alaksh, Gachet, Benoit, Dixit, Zoya, Faure, Roland, Gill, Ryan T., Tenaillon, Olivier

“…RNA polymerase (RNAP) is emblematic of complex biological systems that control multiple traits involving trade-offs such as growth versus maintenance…”
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A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS by McMahon, Mary, Contreras, Adrian, Holm, Mikael, Uechi, Tamayo, Forester, Craig M, Pang, Xiaming, Jackson, Cody, Calvert, Meredith E, Chen, Bin, Quigley, David A, Luk, John M, Kelley, R Kate, Gordan, John D, Gill, Ryan M, Blanchard, Scott C, Ruggero, Davide

“…Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily…”
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Polycystic ovary syndrome (PCOS) is associated with NASH severity and advanced fibrosis by Sarkar, Monika, Terrault, Norah, Chan, Wesley, Cedars, Marcelle I., Huddleston, Heather G., Duwaerts, Caroline C., Balitzer, Dana, Gill, Ryan M.

“…Background Polycystic ovary syndrome (PCOS) affects 10% of reproductive‐aged women, and is marked by irregular menses and high androgens. PCOS is a known risk…”
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Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast by Bradley, Samuel A., Lehka, Beata J., Hansson, Frederik G., Adhikari, Khem B., Rago, Daniela, Rubaszka, Paulina, Haidar, Ahmad K., Chen, Ling, Hansen, Lea G., Gudich, Olga, Giannakou, Konstantina, Lengger, Bettina, Gill, Ryan T., Nakamura, Yoko, de Bernonville, Thomas Dugé, Koudounas, Konstantinos, Romero-Suarez, David, Ding, Ling, Qiao, Yijun, Frimurer, Thomas M., Petersen, Anja A., Besseau, Sébastien, Kumar, Sandeep, Gautron, Nicolas, Melin, Celine, Marc, Jillian, Jeanneau, Remi, O’Connor, Sarah E., Courdavault, Vincent, Keasling, Jay D., Zhang, Jie, Jensen, Michael K.

“…Monoterpenoid indole alkaloids (MIAs) represent a large class of plant natural products with marketed pharmaceutical activities against a wide range of…”
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Rapid profiling of a microbial genome using mixtures of barcoded oligonucleotides by Gill, Ryan T, Warner, Joseph R, Reeder, Philippa J, Karimpour-Fard, Anis, Woodruff, Lauren B A

“…To identify genes affecting traits of interest in E. coli , Warner et al . describe a method to rapidly create and assay rationally mutated versions of every…”
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Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm by Joseph, Nancy M, Brunt, Elizabeth M, Marginean, Celia, Nalbantoglu, ILKe, Snover, Dale C, Thung, Swan N, Yeh, Matthew M, Umetsu, Sarah E, Ferrell, Linda D, Gill, Ryan M

“…Hepatic small vessel neoplasm (HSVN) is a recently described infiltrative vascular neoplasm of the liver, composed of small vessels. Although the infiltrative…”
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A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease by Klair, Jagpal Singh, Yang, Ju Dong, Abdelmalek, Manal F., Guy, Cynthia D., Gill, Ryan M., Yates, Katherine, Unalp‐Arida, Aynur, Lavine, Joel E., Clark, Jeanne M., Diehl, Anna Mae, Suzuki, Ayako

“…Postmenopausal women with nonalcoholic steatohepatitis are at an increased risk of hepatic fibrosis compared with premenopausal women. Whether duration of…”
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Renewable acrylonitrile production by Karp, Eric M., Eaton, Todd R., Nogué, Violeta Sànchez i, Vorotnikov, Vassili, Biddy, Mary J., Tan, Eric C. D., Brandner, David G., Cywar, Robin M., Liu, Rongming, Manker, Lorenz P., Michener, William E., Gilhespy, Michelle, Skoufa, Zinovia, Watson, Michael J., Fruchey, O. Stanley, Vardon, Derek R., Gill, Ryan T., Bratis, Adam D., Beckham, Gregg T.

“…Acrylonitrile (ACN) is a petroleum-derived compound used in resins, polymers, acrylics, and carbon fiber. We present a process for renewable ACN production…”
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Whole Slide Imaging Versus Microscopy for Primary Diagnosis in Surgical Pathology: A Multicenter Blinded Randomized Noninferiority Study of 1992 Cases (Pivotal Study) by Mukhopadhyay, Sanjay, Feldman, Michael D, Abels, Esther, Ashfaq, Raheela, Beltaifa, Senda, Cacciabeve, Nicolas G, Cathro, Helen P, Cheng, Liang, Cooper, Kumarasen, Dickey, Glenn E, Gill, Ryan M, Heaton, Robert P, Kerstens, René, Lindberg, Guy M, Malhotra, Reenu K, Mandell, James W, Manlucu, Ellen D, Mills, Anne M, Mills, Stacey E, Moskaluk, Christopher A, Nelis, Mischa, Patil, Deepa T, Przybycin, Christopher G, Reynolds, Jordan P, Rubin, Brian P, Saboorian, Mohammad H, Salicru, Mauricio, Samols, Mark A, Sturgis, Charles D, Turner, Kevin O, Wick, Mark R, Yoon, Ji Y, Zhao, Po, Taylor, Clive R

“…Most prior studies of primary diagnosis in surgical pathology using whole slide imaging (WSI) versus microscopy have focused on specific organ systems or…”
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