Search Results - "Gill, Parkash S."

AXL mediates resistance to cetuximab therapy by Brand, Toni M, Iida, Mari, Stein, Andrew P, Corrigan, Kelsey L, Braverman, Cara M, Luthar, Neha, Toulany, Mahmoud, Gill, Parkash S, Salgia, Ravi, Kimple, Randall J, Wheeler, Deric L

“…The EGFR antibody cetuximab is used to treat numerous cancers, but intrinsic and acquired resistance to this agent is a common clinical outcome. In this study,…”
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Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis by REN LIU, XIUQING LI, GENYUAN ZHU, LOUIE, Stan, CONTI, Peter S, ZIBO LI, LEE, Amy S, GILL, Parkash S, WENMING GAO, YUE ZHOU, SHIUAN WEY, MITRA, Satyajit K, KRASNOPEROV, Valery, DEZHENG DONG, SHUANGLONG LIU, DAN LI

“…The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy. An oncogenic function of cell…”
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Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion by Scehnet, Jeffrey S., Jiang, Weidong, Ram Kumar, S., Krasnoperov, Valery, Trindade, Alexandre, Benedito, Rui, Djokovic, Dusan, Borges, Cristina, Ley, Eric J., Duarte, Antonio, Gill, Parkash S.

“…Vascular development is dependent on various growth factors and certain modifiers critical for providing arterial or venous identity, interaction with the…”
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PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma by Howard, Emily, Hurrell, Benjamin P, Helou, Doumet Georges, Quach, Christine, Painter, Jacob D, Shafiei-Jahani, Pedram, Fung, Marshall, Gill, Parkash S, Soroosh, Pejman, Sharpe, Arlene H, Akbari, Omid

“…While pulmonary ILC2s represent one of the major tissue-resident innate lymphoid cell populations at steady state and are key drivers of cytokine secretion in…”
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Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis by Djokovic, Dusan, Trindade, Alexandre, Gigante, Joana, Badenes, Marina, Silva, Lilliana, Liu, Ren, Li, Xiuqing, Gong, Ming, Krasnoperov, Valery, Gill, Parkash S, Duarte, Antonio

“…Dll4/Notch and Ephrin-B2/EphB4 pathways play critical roles in tumor vessel development and maturation. This study evaluates the efficacy of the inhibition of…”
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Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos by Trindade, Alexandre, Ram Kumar, S., Scehnet, Jeffrey S., Lopes-da-Costa, Luis, Becker, Jorg, Jiang, Weidong, Liu, Ren, Gill, Parkash S., Duarte, Antonio

“…The importance of Notch signaling pathway in the regulation of vascular development and angiogenesis is suggested by the expression of Notch receptors and…”
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Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression by RAM KUMAR, S, SCEHNET, Jeffrey S, BEART, Robert W, SINGH, Gagandeep, NGUYEN, Cu, KAHN, Michael, GILL, Parkash S, LEY, Eric J, SINGH, Jasbir, KRASNOPEROV, Valery, REN LIU, MANCHANDA, Parmeet K, LADNER, Robert D, HAWES, Debra, WEAVER, Fred A

“…The receptor tyrosine kinase EphB2 is expressed by colon progenitor cells; however, only 39% of colorectal tumors express EphB2 and expression levels decline…”
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A Novel DNA Methylation Signature as an Independent Prognostic Factor in Muscle-Invasive Bladder Cancer by Xu, Zhijie, Gujar, Hemant, Fu, Guanghou, Ahmadi, Hamed, Bhanvadia, Sumeet, Weisenberger, Daniel J, Jin, Baiye, Gill, Parkash S, Gill, Inderbir, Daneshmand, Siamak, Siegmund, Kimberly D, Liang, Gangning

“…Muscle-invasive bladder cancer (MIBC) accounts for approximately 20% of all urothelial bladder carcinomas (UBC) at time of diagnosis, and up to 30% of patients…”
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Receptor Tyrosine Kinase EphB4 Is a Survival Factor in Breast Cancer by Kumar, S. Ram, Singh, Jasbir, Xia, Guangbin, Krasnoperov, Valery, Hassanieh, Loubna, Ley, Eric J., Scehnet, Jeffrey, Kumar, Neil G., Hawes, Debra, Press, Michael F., Weaver, Fred A., Gill, Parkash S.

“…EphB4, a member of the largest family of receptor tyrosine kinases, is normally expressed on endothelial and neuronal cells. Although aberrant expression of…”
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The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth by Kertesz, Nathalie, Krasnoperov, Valery, Reddy, Ramachandra, Leshanski, Lucy, Kumar, S. Ram, Zozulya, Sergey, Gill, Parkash S.

“…The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play a crucial role in vascular development during embryogenesis. The soluble monomeric derivative…”
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Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesis by Trindade, Alexandre, Djokovic, Dusan, Gigante, Joana, Badenes, Marina, Pedrosa, Ana-Rita, Fernandes, Ana-Carina, Lopes-da-Costa, Luís, Krasnoperov, Valery, Liu, Ren, Gill, Parkash S, Duarte, António

“…Recent findings regarding Dll4 function in physiological and pathological conditions indicate that this Notch ligand may constitute an important therapeutic…”
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Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways by Li, Grace X, Zhang, Shaobing, Liu, Ren, Singh, Bani, Singh, Sukhmani, Quinn, David I, Crump, Gage, Gill, Parkash S

“…The VEGF pathway is critically required for vasculogenesis, the formation of the primary vascular network. It is also required for angiogenesis resulting in…”
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The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target by Ferguson, Benjamin D, Liu, Ren, Rolle, Cleo E, Tan, Yi-Hung Carol, Krasnoperov, Valery, Kanteti, Rajani, Tretiakova, Maria S, Cervantes, Gustavo M, Hasina, Rifat, Hseu, Robyn D, Iafrate, A John, Karrison, Theodore, Ferguson, Mark K, Husain, Aliya N, Faoro, Leonardo, Vokes, Everett E, Gill, Parkash S, Salgia, Ravi

“…Despite progress in locoregional and systemic therapies, patient survival from lung cancer remains a challenge. Receptor tyrosine kinases are frequently…”
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Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor–positive human tumors by Masood, Rizwan, Cai, Jie, Zheng, Tong, Smith, D. Lynne, Hinton, David R., Gill, Parkash S.

“…Angiogenesis is required for the progression of tumors from a benign to a malignant phenotype and for metastasis. Malignant tumor cells secrete factors such as…”
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The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladder by Li, Xiuqing, Choi, Wesley W, Yan, Rui, Yu, Haiyang, Krasnoperov, Valery, Kumar, S Ram, Schuckman, Anne, Klumpp, David J, Pan, Chong-Xian, Quinn, David, Gill, Inderbir S, Gill, Parkash S, Liu, Ren

“…Effective treatment of transitional cell carcinoma (TCC) of the bladder requires early diagnosis. Identifying novel molecular markers in TCC would guide the…”
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KSHV-induced notch components render endothelial and mural cell characteristics and cell survival by Liu, Ren, Li, Xiuqing, Tulpule, Anil, Zhou, Yue, Scehnet, Jeffrey S., Zhang, Shaobing, Lee, Jong-Soo, Chaudhary, Preet M., Jung, Jae, Gill, Parkash S.

“…Kaposi sarcoma–associated herpesvirus (KSHV) infection is essential to the development of Kaposi sarcoma (KS). Notch signaling is also known to play a pivotal…”
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The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade by Scehnet, Jeffrey S., Ley, Eric J., Krasnoperov, Valery, Liu, Ren, Manchanda, Parmeet K., Sjoberg, Eric, Kostecke, Anna P., Gupta, Sachin, Kumar, S. Ram, Gill, Parkash S.

“…Kaposi sarcoma (KS) is associated with human herpesvirus (HHV)-8 and is dependent on the induction of vascular endothelial growth factors (VEGFs). VEGF…”
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Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung Cancer by Ferguson, Benjamin D., Carol Tan, Yi-Hung, Kanteti, Rajani S., Liu, Ren, Gayed, Matthew J., Vokes, Everett E., Ferguson, Mark K., John Iafrate, A., Gill, Parkash S., Salgia, Ravi

“…Lung cancer outcomes remain poor despite the identification of several potential therapeutic targets. The EPHB4 receptor tyrosine kinase (RTK) has recently…”
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Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancer by Xia, Guangbin, Kumar, S Ram, Hawes, Debra, Cai, Jie, Hassanieh, Loubna, Groshen, Susan, Zhu, Sutao, Masood, Rizwan, Quinn, David I, Broek, Daniel, Stein, John P, Gill, Parkash S

“…Vascular endothelial growth factor has a critical role in maintaining tumor microvasculature and, as such, is an attractive target for anti-angiogenic therapy…”
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EphB4 expression and biological significance in prostate cancer by GUANGBIN XIA, RAM KUMAR, S, DANESHMAND, Siamak, BUSCARINI, Maurizio, STEIN, John P, CHEN ZHONG, BROCK, Daniel, ROY-BURMAN, Pradip, GILL, Parkash S, MASOOD, Rizwan, SUTAO ZHU, REDDY, Ramchandra, KRASNOPEROV, Valery, QUINN, David I, HENSHALL, Susan M, SUTHERLAND, Robert L, PINSKI, Jacek K

“…Prostate cancer is the most common cancer in men. Advanced prostate cancer spreading beyond the gland is incurable. Identifying factors that regulate the…”
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