Search Results - "Gill, Katherine L"

A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins by Gill, Katherine L., Gardner, Iain, Li, Linzhong, Jamei, Masoud

“…The ability to predict subcutaneous (SC) absorption rate and tissue distribution of therapeutic proteins (TPs) using a bottom-up approach is highly desirable…”
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Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics by Gill, Katherine L., Machavaram, Krishna K., Rose, Rachel H., Chetty, Manoranjenni

“…Understanding inter-subject variability in drug pharmacokinetics and pharmacodynamics is important to ensure that all patients attain suitable drug exposure to…”
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Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities by Rose, Rachel H., Sepp, Armin, Stader, Felix, Gill, Katherine L., Liu, Cong, Gardner, Iain

“…The past two decades have seen diversification of drug development pipelines and approvals from traditional small molecule therapies to alternative modalities…”
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Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: utility of in vitro and in vivo data by Gill, Katherine L, Gertz, Michael, Houston, J Brian, Galetin, Aleksandra

“…A physiologically based pharmacokinetic (PBPK) modeling approach was used to assess the prediction accuracy of propofol hepatic and extrahepatic metabolic…”
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Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors by Huang, Weize, Stader, Felix, Chan, Phyllis, Shemesh, Colby S., Chen, Yuan, Gill, Katherine L., Jones, Hannah M., Li, Linzhong, Rossato, Gianluca, Wu, Benjamin, Jin, Jin Y., Chanu, Pascal

“…Background: Atezolizumab has been studied in multiple indications for both pediatric and adult patient populations. Generally, clinical studies enrolling…”
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Physiologically Based Pharmacokinetic Modeling To Predict Drug-Biologic Interactions with Cytokine Modulators: Are These Relevant and Is Interleukin-6 Enough? by Chen, Kuan-Fu, Jones, Hannah M., Gill, Katherine L.

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Opportunities and Challenges for PBPK Model of mAbs in Paediatrics and Pregnancy by Gill, Katherine L., Jones, Hannah M.

“…New drugs may in some cases need to be tested in paediatric and pregnant patients. However, it is difficult to recruit such patients and there are many ethical…”
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Characterization of in vitro glucuronidation clearance of a range of drugs in human kidney microsomes: comparison with liver and intestinal glucuronidation and impact of albumin by Gill, Katherine L, Houston, J Brian, Galetin, Aleksandra

“…Previous studies have shown the importance of the addition of albumin for characterization of hepatic glucuronidation in vitro; however, no reports exist on…”
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Development and Application of a Physiologically-Based Pharmacokinetic Model to Predict the Pharmacokinetics of Therapeutic Proteins from Full-term Neonates to Adolescents by Pan, Xian, Stader, Felix, Abduljalil, Khaled, Gill, Katherine L., Johnson, Trevor N., Gardner, Iain, Jamei, Masoud

“…Physiologically-based pharmacokinetic (PBPK) modelling provides an integrated framework to predict the disposition of small molecule drugs in children and is…”
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Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis by Burt, Howard J, Riedmaier, Arian Emami, Harwood, Matthew D, Crewe, H Kim, Gill, Katherine L, Neuhoff, Sibylle

“…This study aimed to derive quantitative abundance values for key hepatic transporters suitable for in vitro-in vivo extrapolation within a physiologically…”
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Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations by Machavaram, Krishna K., Endo-Tsukude, Chihiro, Terao, Kimio, Gill, Katherine L., Hatley, Oliver J., Gardner, Iain, Parrott, Neil, Ducray, Patricia Sanwald

“…A physiologically based pharmacokinetic (PBPK) model was used to simulate the impact of elevated levels of interleukin (IL)-6 on the exposure of several orally…”
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Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site by Musther, Helen, Gill, Katherine L., Chetty, Manoranjenni, Rostami-Hodjegan, Amin, Rowland, Malcolm, Jamei, Masoud

“…Physiologically based pharmacokinetic (PBPK) models can over-predict maximum plasma concentrations (C max ) following intravenous administration. A proposed…”
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Are Physiologically Based Pharmacokinetic Models Reporting the Right C(max)? Central Venous Versus Peripheral Sampling Site by Musther, Helen, Gill, Katherine L, Chetty, Manoranjenni, Rostami-Hodjegan, Amin, Rowland, Malcolm, Jamei, Masoud

“…Physiologically based pharmacokinetic (PBPK) models can over-predict maximum plasma concentrations (C(max)) following intravenous administration. A proposed…”
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