Search Results - "Gill, Avinash"

Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System by Zimmerman, Erik S, Heibeck, Tyler H, Gill, Avinash, Li, Xiaofan, Murray, Christopher J, Madlansacay, Mary Rose, Tran, Cuong, Uter, Nathan T, Yin, Gang, Rivers, Patrick J, Yam, Alice Y, Wang, Willie D, Steiner, Alexander R, Bajad, Sunil U, Penta, Kalyani, Yang, Wenjin, Hallam, Trevor J, Thanos, Christopher D, Sato, Aaron K

“…Antibody–drug conjugates (ADCs) are a targeted chemotherapeutic currently at the cutting edge of oncology medicine. These hybrid molecules consist of a tumor…”
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Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform by Enquist-Newman, Maria, Faust, Ann Marie E., Bravo, Daniel D., Santos, Christine Nicole S., Raisner, Ryan M., Hanel, Arthur, Sarvabhowman, Preethi, Le, Chi, Regitsky, Drew D., Cooper, Susan R., Peereboom, Lars, Clark, Alana, Martinez, Yessica, Goldsmith, Joshua, Cho, Min Y., Donohoue, Paul D., Luo, Lily, Lamberson, Brigit, Tamrakar, Pramila, Kim, Edward J., Villari, Jeffrey L., Gill, Avinash, Tripathi, Shital A., Karamchedu, Padma, Paredes, Carlos J., Rajgarhia, Vineet, Kotlar, Hans Kristian, Bailey, Richard B., Miller, Dennis J., Ohler, Nicholas L., Swimmer, Candace, Yoshikuni, Yasuo

“…Saccharomyces cerevisiae bearing engineered alginate and mannitol catabolic pathways can ferment sugars from brown macroalgae to produce ethanol, potentially…”
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A targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies by Vij, Rajesh, Lin, Zhonghua, Chiang, Nancy, Vernes, Jean-Michel, Storek, Kelly M., Park, Summer, Chan, Joyce, Meng, Y. Gloria, Comps-Agrar, Laetitia, Luan, Peng, Lee, Sophia, Schneider, Kellen, Bevers, Jack, Zilberleyb, Inna, Tam, Christine, Koth, Christopher M., Xu, Min, Gill, Avinash, Auerbach, Marcy R., Smith, Peter A., Rutherford, Steven T., Nakamura, Gerald, Seshasayee, Dhaya, Payandeh, Jian, Koerber, James T.

“…Outer membrane proteins (OMPs) in Gram-negative bacteria are essential for a number of cellular functions including nutrient transport and drug efflux…”
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RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates by Yin, Gang, Stephenson, Heather T., Yang, Junhao, Li, Xiaofan, Armstrong, Stephanie M., Heibeck, Tyler H., Tran, Cuong, Masikat, Mary Rose, Zhou, Sihong, Stafford, Ryan L., Yam, Alice Y., Lee, John, Steiner, Alexander R., Gill, Avinash, Penta, Kalyani, Pollitt, Sonia, Baliga, Ramesh, Murray, Christopher J., Thanos, Christopher D., McEvoy, Leslie M., Sato, Aaron K., Hallam, Trevor J.

“…Amber codon suppression for the insertion of non-natural amino acids (nnAAs) is limited by competition with release factor 1 (RF1). Here we describe the genome…”
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Enhanced Efficacy without Further Cleft Closure: Reevaluating Twist as a Source of Agonist Efficacy in AMPA Receptors by Birdsey-Benson, Amanda, Gill, Avinash, Henderson, Leslie P, Madden, Dean R

“…AMPA receptors (AMPARs) are tetrameric ligand-gated ion channels that couple the energy of glutamate binding to the opening of a transmembrane channel…”
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Enhanced Antimicrobial Activity of Engineered Human Lysozyme by Scanlon, Thomas C, Teneback, Charlotte C, Gill, Avinash, Bement, Jenna L, Weiner, Joshua A, Lamppa, John W, Leclair, Laurie W, Griswold, Karl E

“…Lysozymes contain a disproportionately large fraction of cationic residues, and are thereby attracted toward the negatively charged surface of bacterial…”
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Crystal structure of a charge engineered human lysozyme having enhanced bactericidal activity by Gill, Avinash, Scanlon, Thomas C, Osipovitch, Daniel C, Madden, Dean R, Griswold, Karl E

“…Human lysozyme is a key component of the innate immune system, and recombinant forms of the enzyme represent promising leads in the search for therapeutic…”
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Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry by Kschonsak, Marc, Rougé, Lionel, Arthur, Christopher P., Hoangdung, Ho, Patel, Nidhi, Kim, Ingrid, Johnson, Matthew C., Kraft, Edward, Rohou, Alexis L., Gill, Avinash, Martinez-Martin, Nadia, Payandeh, Jian, Ciferri, Claudio

“…Human cytomegalovirus (HCMV) infects the majority of the human population and represents the leading viral cause of congenital birth defects. HCMV utilizes the…”
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Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain by Shcherbatko, Anatoly, Rossi, Andrea, Foletti, Davide, Zhu, Guoyun, Bogin, Oren, Galindo Casas, Meritxell, Rickert, Mathias, Hasa-Moreno, Adela, Bartsevich, Victor, Crameri, Andreas, Steiner, Alexander R., Henningsen, Robert, Gill, Avinash, Pons, Jaume, Shelton, David L., Rajpal, Arvind, Strop, Pavel

“…The prominent role of voltage-gated sodium channel 1.7 (Nav1.7) in nociception was revealed by remarkable human clinical and genetic evidence. Development of…”
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Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice by Lombana, T Noelle, Rajan, Sharmila, Zorn, Julie A, Mandikian, Danielle, Chen, Eugene C, Estevez, Alberto, Yip, Victor, Bravo, Daniel D, Phung, Wilson, Farahi, Farzam, Viajar, Sharon, Lee, Sophia, Gill, Avinash, Sandoval, Wendy, Wang, Jianyong, Ciferri, Claudio, Boswell, C Andrew, Matsumoto, Marissa L, Spiess, Christoph

“…IgA antibodies have broad potential as a novel therapeutic platform based on their superior receptor-mediated cytotoxic activity, potent neutralization of…”
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Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process by Xu, Ankai, Kim, Hok Seon, Estee, Samarkand, ViaJar, Sharon, Galush, William J, Gill, Avinash, Hötzel, Isidro, Lazar, Greg A, McDonald, Paul, Andersen, Nisana, Spiess, Christoph

“…A critical part of the clinical development path for a therapeutic antibody involves evaluating the physical and chemical stability of candidate molecules…”
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Optimizing the pharmacokinetic properties of polymeric IgA in mice by Rajan, Sharmila, Lombaba, Noelle Twyla, Mandikian, Danielle, Boswell, Andy, Yip, Victor, Bravo-Perez, Daniel, Chen, Eugene, Wang, Jianyong, Phung, Wilson, Lee, Sophia, Farahi, Farzam, Estevez, Alberto, Gill, Avinash, Sandoval, Wendy, Viajar, Sharon, Ciferri, Claudio, Matsumoto, Masrissa, Spiess, Christoph

“…Abstract IgA antibodies have broad potential as a novel therapeutic platform based on their superior receptor-mediated cytotoxic activity, potent…”
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Automated high throughput microscale antibody purification workflows for accelerating antibody discovery by Luan, Peng, Lee, Sophia, Arena, Tia A, Paluch, Maciej, Kansopon, Joe, Viajar, Sharon, Begum, Zahira, Chiang, Nancy, Nakamura, Gerald, Hass, Philip E, Wong, Athena W, Lazar, Greg A, Gill, Avinash

“…To rapidly find "best-in-class" antibody therapeutics, it has become essential to develop high throughput (HTP) processes that allow rapid assessment of…”
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In vitro Fab display: a cell-free system for IgG discovery by Stafford, Ryan L., Matsumoto, Marissa L., Yin, Gang, Cai, Qi, Fung, Juan Jose, Stephenson, Heather, Gill, Avinash, You, Monica, Lin, Shwu-Hwa, Wang, Willie D., Masikat, Mary Rose, Li, Xiaofan, Penta, Kalyani, Steiner, Alex R., Baliga, Ramesh, Murray, Christopher J., Thanos, Christopher D., Hallam, Trevor J., Sato, Aaron K.

“…Selection technologies such as ribosome display enable the rapid discovery of novel antibody fragments entirely in vitro. It has been assumed that the open…”
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A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain by Clausen, Rasmus P., Mohr, Andreas Ø., Riise, Erik, Jensen, Anders A., Gill, Avinash, Madden, Dean R., Kastrup, Jette S., Skottrup, Peter D.

“…A method for development of murine Fab fragments towards extracellular domains of a surface receptor is presented. The GluA4 ionotropic glutamate receptor is…”
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Correlating AMPA Receptor Activation and Cleft Closure across Subunits: Crystal Structures of the GluR4 Ligand-Binding Domain in Complex with Full and Partial Agonists by Gill, Avinash, Birdsey-Benson, Amanda, Jones, Brian L, Henderson, Leslie P, Madden, Dean R

“…AMPA receptors are glutamate-gated ion channels that are essential mediators of synaptic signals in the central nervous system. They form tetramers that are…”
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Domain architecture of a calcium-permeable AMPA receptor in a ligand-free conformation by Midgett, Charles R, Gill, Avinash, Madden, Dean R

“…Ligand-gated ion channels couple the free energy of agonist binding to the gating of selective transmembrane ion pores, permitting cells to regulate ion flux…”
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Understanding AMPA receptor function and assembly, one piece at a time: Structural and biochemical analysis of GluR4 ligand-binding and ecto-domains by Gill, Avinash

“…AMPA receptors are glutamate-gated ion channels that mediate most of the excitatory synaptic signals in the central nervous system. They form tetrameric…”
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Purification and crystallization of a non-GluR2 AMPA-receptor ligand-binding domain: a case of cryo-incompatibility addressed by room-temperature data collection by Gill, Avinash, Madden, Dean R.

“…Glutamate is the major excitatory neurotransmitter in the brain. Among the cognate ionotropic glutamate receptors, the subfamily selective for AMPA…”
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Understanding AMPA receptor function and assembly, one piece at a time: Structural and biochemical analysis of GluR4 ligand-binding and ecto-domains by Gill, Avinash

“…AMPA receptors are glutamate-gated ion channels that mediate most of the excitatory synaptic signals in the central nervous system. They form tetrameric…”
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