Search Results - "Gill, Andrew C."

Physiological Functions of the Cellular Prion Protein by Castle, Andrew R, Gill, Andrew C

“…The prion protein, PrP , is a small, cell-surface glycoprotein notable primarily for its critical role in pathogenesis of the neurodegenerative disorders known…”
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Lysine-Directed Post-translational Modifications of Tau Protein in Alzheimer's Disease and Related Tauopathies by Kontaxi, Christiana, Piccardo, Pedro, Gill, Andrew C

“…Tau is a microtubule-associated protein responsible mainly for stabilizing the neuronal microtubule network in the brain. Under normal conditions, tau is…”
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β-hairpin-mediated formation of structurally distinct multimers of neurotoxic prion peptides by Gill, Andrew C

“…Protein misfolding disorders are associated with conformational changes in specific proteins, leading to the formation of potentially neurotoxic amyloid…”
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Staphylococcus aureus Lipase 1 Enhances Influenza A Virus Replication by Goncheva, Mariya I, Conceicao, Carina, Tuffs, Stephen W, Lee, Hui-Min, Quigg-Nicol, Marlynne, Bennet, Ian, Sargison, Fiona, Pickering, Amy C, Hussain, Saira, Gill, Andrew C, Dutia, Bernadette M, Digard, Paul, Fitzgerald, J Ross

“…Influenza A virus (IAV) causes annual epidemics of respiratory disease in humans, often complicated by secondary coinfection with bacterial pathogens such as…”
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A chicken bioreactor for efficient production of functional cytokines by Herron, Lissa R, Pridans, Clare, Turnbull, Matthew L, Smith, Nikki, Lillico, Simon, Sherman, Adrian, Gilhooley, Hazel J, Wear, Martin, Kurian, Dominic, Papadakos, Grigorios, Digard, Paul, Hume, David A, Gill, Andrew C, Sang, Helen M

“…The global market for protein drugs has the highest compound annual growth rate of any pharmaceutical class but their availability, especially outside of the…”
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Statistical Evidence for a Helical Nascent Chain by Cruzeiro, Leonor, Gill, Andrew C, Eilbeck, J Chris

“…We investigate the hypothesis that protein folding is a kinetic, non-equilibrium process, in which the structure of the nascent chain is crucial. We compare…”
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The Role of the Mammalian Prion Protein in the Control of Sleep by Roguski, Amber, Gill, Andrew C

“…Sleep disruption is a prevalent clinical feature in many neurodegenerative disorders, including human prion diseases where it can be the defining dysfunction,…”
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Reduced levels of dopamine and altered metabolism in brains of HPRT knock-out rats: a new rodent model of Lesch-Nyhan Disease by Meek, Stephen, Thomson, Alison J., Sutherland, Linda, Sharp, Matthew G. F., Thomson, Julie, Bishop, Valerie, Meddle, Simone L., Gloaguen, Yoann, Weidt, Stefan, Singh-Dolt, Karamjit, Buehr, Mia, Brown, Helen K., Gill, Andrew C., Burdon, Tom

“…Lesch-Nyhan disease (LND) is a severe neurological disorder caused by loss-of-function mutations in the gene encoding hypoxanthine phosphoribosyltransferase…”
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Prion protein-specific antibodies that detect multiple TSE agents with high sensitivity by McCutcheon, Sandra, Langeveld, Jan P M, Tan, Boon Chin, Gill, Andrew C, de Wolf, Christopher, Martin, Stuart, Gonzalez, Lorenzo, Alibhai, James, Blanco, A Richard Alejo, Campbell, Lauren, Hunter, Nora, Houston, E Fiona

“…This paper describes the generation, characterisation and potential applications of a panel of novel anti-prion protein monoclonal antibodies (mAbs). The mAbs…”
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Effects of mutations in the effector domain of influenza A virus NS1 protein by Pereira, Carina F, Wise, Helen M, Kurian, Dominic, Pinto, Rute M, Amorim, Maria J, Gill, Andrew C, Digard, Paul

“…The multifunctional NS1 protein of influenza A virus has roles in antagonising cellular innate immune responses and promoting viral gene expression. To better…”
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Sex‐dependent changes in neuroactive steroid concentrations in the rat brain following acute swim stress by Sze, Ying, Gill, Andrew C., Brunton, Paula J.

“…Sex differences in hypothalamic‐pituitary‐adrenal (HPA) axis activity are well established in rodents. In addition to glucocorticoids, stress also stimulates…”
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Na+/K+-ATPase is present in scrapie-associated fibrils, modulates PrP misfolding in vitro and links PrP function and dysfunction by Graham, James F, Kurian, Dominic, Agarwal, Sonya, Toovey, Lorna, Hunt, Lawrence, Kirby, Louise, Pinheiro, Teresa J T, Banner, Steven J, Gill, Andrew C

“…Transmissible spongiform encephalopathies are characterised by widespread deposition of fibrillar and/or plaque-like forms of the prion protein. These…”
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Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt‐Jakob Disease by Bocharova, Olga V., Breydo, Leonid, Salnikov, Vadim V., Gill, Andrew C., Baskakov, Ilia V.

“…In recent studies, the amyloid form of recombinant prion protein (PrP) encompassing residues 89–230 (rPrP 89‐230) produced in vitro induced transmissible prion…”
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The Microneme Proteins EtMIC4 and EtMIC5 of Eimeria tenella Form a Novel, Ultra-high Molecular Mass Protein Complex That Binds Target Host Cells by Periz, Javier, Gill, Andrew C., Hunt, Lawrence, Brown, Philip, Tomley, Fiona M.

“…Eimeria tenella, in common with other parasitic protozoa of the phylum Apicomplexa, invades host cells using an actinomyosin-powered “glideosome” complex and…”
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Raman Optical Activity Demonstrates Poly( l-proline) II Helix in the N-terminal Region of the Ovine Prion Protein: Implications for Function and Misfunction by Blanch, Ewan W., Gill, Andrew C., Rhie, Alexandre G.O., Hope, James, Hecht, Lutz, Nielsen, Kurt, Barron, Laurence D.

“…The aqueous solution structure of the full-length recombinant ovine prion protein PrP 25-233, together with that of the N-terminal truncated version PrP…”
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High-resolution differentiation of transmissible spongiform encephalopathy strains by quantitative N-terminal amino acid profiling (N-TAAP) of PK-digested abnormal prion protein by Gielbert, Adriana, Davis, Linda A, Sayers, A. Robin, Hope, James, Gill, Andrew C, Sauer, Maurice J

“…New forms of transmissible spongiform encephalopathy (TSE) continue to be identified, and consequently sensitive differential diagnosis is increasingly…”
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Microbiota in Exhaled Breath Condensate and the Lung by Glendinning, Laura, Wright, Steven, Tennant, Peter, Gill, Andrew C, Collie, David, McLachlan, Gerry

“…The lung microbiota is commonly sampled using relatively invasive bronchoscopic procedures. Exhaled breath condensate (EBC) collection potentially offers a…”
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Effect of enzymatic deimination on the conformation of recombinant prion protein by Young, Duncan S., Meersman, Filip, Oxley, David, Webster, Judith, Gill, Andrew C., Bronstein, Igor, Lowe, Christopher R., Dear, Denise V.

“…Deimination is the post-translational conversion of arginine residues to citrulline. It has been implicated as a causative factor in autoimmune diseases such…”
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PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions by Barron, Rona M., King, Declan, Jeffrey, Martin, McGovern, Gillian, Agarwal, Sonya, Gill, Andrew C., Piccardo, Pedro

“…Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic…”
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Synthesis and structural characterization of a mimetic membrane‐anchored prion protein by Hicks, Matthew R., Gill, Andrew C., Bath, Imanpreet K., Rullay, Atvinder K., Sylvester, Ian D., Crout, David H., Pinheiro, Teresa J. T.

“…During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in…”
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