Search Results - "Gill, Alexander J."

Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased neuroimmune activation and risk for encephalitis in HIV infection by Gill, Alexander J, Garza, Rolando, Ambegaokar, Surendra S, Gelman, Benjamin B, Kolson, Dennis L

“…Heme oxygenase-1 (HO-1) is a critical cytoprotective enzyme that limits oxidative stress, inflammation, and cellular injury within the central nervous system…”
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Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy by Gill, Alexander J, Kolson, Dennis L

“…The persistence of chronic immune activation and oxidative stress in human immunodeficiency virus (HIV)-infected, antiretroviral drug-treated individuals are…”
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Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation by Smith, Matthew D, Chamling, Xitiz, Gill, Alexander J, Martinez, Hector, Li, Weifeng, Fitzgerald, Kathryn C, Sotirchos, Elias S, Moroziewicz, Dorota, Bauer, Lauren, Paull, Daniel, Gharagozloo, Marjan, Bhargava, Pavan, Zack, Donald J, Fossati, Valentina, Calabresi, Peter A

“…Astrocytes are instrumental in maintaining central nervous system (CNS) homeostasis and responding to injury. A major limitation of studying neurodegenerative…”
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Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection by Garcia-Mesa, Yoelvis, Xu, He N, Vance, Patricia, Gruenewald, Analise L, Garza, Rolando, Midkiff, Cecily, Alvarez-Hernandez, Xavier, Irwin, David J, Gill, Alexander J, Kolson, Dennis L

“…Dimethyl fumarate (DMF), an antioxidant/anti-inflammatory drug approved for the treatment of multiple sclerosis, induces antioxidant enzymes, in part through…”
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Nivolumab‐associated Lambert‐Eaton myasthenic syndrome and cerebellar dysfunction in a patient with a neuroendocrine tumor by Gill, Alexander J., Gandhy, Shreya, Lancaster, Eric

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Pathogenic mechanisms in neuronal surface autoantibody-mediated encephalitis by Gill, Alexander J., Venkatesan, Arun

“…In recent years, autoimmune encephalitis associated with antibodies against neuronal cell surface proteins has become a well-recognized phenomenon. Here, we…”
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Neurodegeneration and demyelination in multiple sclerosis by Garton, Thomas, Gadani, Sachin P, Gill, Alexander J, Calabresi, Peter A

“…Progressive multiple sclerosis (PMS) is an immune-initiated neurodegenerative condition that lacks effective therapies. Although peripheral immune infiltration…”
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Distinct mechanisms of oligodendrocyte injury inform therapeutic interventions in multiple sclerosis by Garton, Thomas, Gill, Alexander J, Calabresi, Peter A

“…This scientific commentary refers to ‘Diverse injury responses of human oligodendrocytes to mediators implicated in multiple sclerosis’ by Pernin et al…”
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Emerging imaging and liquid biomarkers in multiple sclerosis by Gill, Alexander J., Schorr, Emily M., Gadani, Sachin P., Calabresi, Peter A.

“…The advent of highly effective disease modifying therapy has transformed the landscape of multiple sclerosis (MS) care over the last two decades. However,…”
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Central and peripheral markers of neurodegeneration and monocyte activation in HIV-associated neurocognitive disorders by McGuire, Jennifer L, Gill, Alexander J, Douglas, Steven D, Kolson, Dennis L

“…HIV-associated neurocognitive disorders (HAND) affect up to 50 % of HIV-infected adults, independently predict HIV morbidity/mortality, and are associated with…”
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Neurologic Outcomes in People With Multiple Sclerosis Treated With Immune Checkpoint Inhibitors for Oncologic Indications by Quinn, Carson M., Rajarajan, Prashanth, Gill, Alexander J., Kopinsky, Hannah, Wolf, Andrew B., de Camargo, Celeste Soares, Lamb, Jessica, Bacon, Tamar E., Murray, Joseph C., Probasco, John C., Galetta, Kristin M., Kantor, Daniel, Coyle, Patricia, Bhise, Vikram, Alvarez, Enrique, Conway, Sarah E., Bhattacharyya, Shamik, Kister, Ilya

“…Immune checkpoint inhibitors (ICIs) are increasingly used against various cancers but are associated with immune-related adverse events (irAEs). Risk of irAEs…”
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Neuropathogenesis of HIV-associated neurocognitive disorders: roles for immune activation, HIV blipping and viral tropism by Chen, Maria F, Gill, Alexander J, Kolson, Dennis L

“…PURPOSE OF REVIEWThe purpose of this study is to discuss why HIV-associated neurocognitive disorders (HAND) persist despite apparently effective HIV…”
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Chronic Inflammation and the Role for Cofactors (Hepatitis C, Drug Abuse, Antiretroviral Drug Toxicity, Aging) in HAND Persistence by Gill, Alexander J., Kolson, Dennis L.

“…HIV-associated neurocognitive disorders (HAND) is a group of syndromes of varying degrees of cognitive impairment affecting up to 50 % of HIV-infected…”
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Degradation of heme oxygenase‐1 by the immunoproteasome in astrocytes: A potential interferon‐γ‐dependent mechanism contributing to HIV neuropathogenesis by Kovacsics, Colleen E., Gill, Alexander J., Ambegaokar, Surendra S., Gelman, Benjamin B., Kolson, Dennis L.

“…Induction of the detoxifying enzyme heme oxygenase‐1 (HO‐1) is a critical protective host response to cellular injury associated with inflammation and…”
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Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders by Gill, Alexander J, Kovacsics, Colleen E, Cross, Stephanie A, Vance, Patricia J, Kolson, Lorraine L, Jordan-Sciutto, Kelly L, Gelman, Benjamin B, Kolson, Dennis L

“…Heme oxygenase-1 (HO-1) is an inducible, detoxifying enzyme that is critical for limiting oxidative stress, inflammation, and cellular injury within the CNS…”
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Neuroinflammation associates with antioxidant heme oxygenase-1 response throughout the brain in persons living with HIV by Gruenewald, Analise L., Garcia-Mesa, Yoelvis, Gill, Alexander J, Garza, Rolando, Gelman, Benjamin B., Kolson, Dennis L.

“…Previous studies showed that persons living with HIV (PLWH) demonstrate higher brain prefrontal cortex neuroinflammation and immunoproteasome expression…”
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Induction of Heme Oxygenase-1 Deficiency and Associated Glutamate-Mediated Neurotoxicity Is a Highly Conserved HIV Phenotype of Chronic Macrophage Infection That Is Resistant to Antiretroviral Therapy by Gill, Alexander J, Kovacsics, Colleen E, Vance, Patricia J, Collman, Ronald G, Kolson, Dennis L

“…Expression of the cytoprotective enzyme heme oxygenase-1 (HO-1) is significantly reduced in the brain prefrontal cortex of HIV-positive individuals with…”
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The complement system, neuronal injury, and cognitive function in horizontally-acquired HIV-infected youth by McGuire, Jennifer L., Gill, Alexander J., Douglas, Steven D., Kolson, Dennis L.

“…The complement system (C1q/C3) is a key mediator of synaptic pruning during normal development. HIV inappropriately induces C1q and C3 production in the brain,…”
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HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation by Gannon, Patrick J, Akay-Espinoza, Cagla, Yee, Alan C, Briand, Lisa A, Erickson, Michelle A, Gelman, Benjamin B, Gao, Yan, Haughey, Norman J, Zink, M. Christine, Clements, Janice E, Kim, Nicholas S, Van De Walle, Gabriel, Jensen, Brigid K, Vassar, Robert, Pierce, R. Christopher, Gill, Alexander J, Kolson, Dennis L, Diehl, J. Alan, Mankowski, Joseph L, Jordan-Sciutto, Kelly L

“…Mounting evidence implicates antiretroviral (ARV) drugs as potential contributors to the persistence and evolution of clinical and pathological presentation of…”
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Heme oxygenase-1 promoter (GT)n polymorphism associates with HIV neurocognitive impairment by Garza, Rolando, Gill, Alexander J., Bastien, Brandon L., Garcia-Mesa, Yoelvis, Gruenewald, Analise L., Gelman, Benjamin B., Tsima, Billy, Gross, Robert, Letendre, Scott L., Kolson, Dennis L.

“…To determine whether regulatory variations in the heme oxygenase-1 (HO-1) promoter (GT) dinucleotide repeat length could identify unique population genetic…”
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