Search Results - "Gilio, Karen"

Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2 by Konopatskaya, Olga, Matthews, Sharon A., Harper, Matthew T., Gilio, Karen, Cosemans, Judith M.E.M., Williams, Christopher M., Navarro, Maria N., Carter, Deborah A., Heemskerk, Johan W.M., Leitges, Michael, Cantrell, Doreen, Poole, Alastair W.

“…Platelets are highly specialized blood cells critically involved in hemostasis and thrombosis. Members of the protein kinase C (PKC) family have established…”
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Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation by Hall, Kellie J, Harper, Matthew T, Gilio, Karen, Cosemans, Judith M, Heemskerk, Johan W M, Poole, Alastair W

“…PKCtheta is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCtheta(-/-) T cells exhibit reduced activation and…”
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Dual Mechanism of Integrin αIIbβ3 Closure in Procoagulant Platelets by Mattheij, Nadine J.A., Gilio, Karen, van Kruchten, Roger, Jobe, Shawn M., Wieschhaus, Adam J., Chishti, Athar H., Collins, Peter, Heemskerk, Johan W.M., Cosemans, Judith M.E.M.

“…Aggregation of platelets via activated integrin αIIbβ3 is a prerequisite for thrombus formation. Phosphatidylserine-exposing platelets with a key role in the…”
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PKCα regulates platelet granule secretion and thrombus formation in mice by Konopatskaya, Olga, Gilio, Karen, Harper, Matthew T, Zhao, Yan, Cosemans, Judith M.E.M, Karim, Zubair A, Whiteheart, Sidney W, Molkentin, Jeffery D, Verkade, Paul, Watson, Steve P, Heemskerk, Johan W.M, Poole, Alastair W

“…Platelets are central players in atherothrombosis development in coronary artery disease. The PKC family provides important intracellular mechanisms for…”
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Dual-Specificity Phosphatase 3 Deficiency or Inhibition Limits Platelet Activation and Arterial Thrombosis by Musumeci, Lucia, Kuijpers, Marijke J, Gilio, Karen, Hego, Alexandre, Théâtre, Emilie, Maurissen, Lisbeth, Vandereyken, Maud, Diogo, Catia V, Lecut, Christelle, Guilmain, William, Bobkova, Ekaterina V, Eble, Johannes A, Dahl, Russell, Drion, Pierre, Rascon, Justin, Mostofi, Yalda, Yuan, Hongbin, Sergienko, Eduard, Chung, Thomas D.Y, Thiry, Marc, Senis, Yotis, Moutschen, Michel, Mustelin, Tomas, Lancellotti, Patrizio, Heemskerk, Johan W.M, Tautz, Lutz, Oury, Cécile, Rahmouni, Souad

“…BACKGROUND—A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. A better understanding of…”
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Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation by Gilio, Karen, van Kruchten, Roger, Braun, Attila, Berna-Erro, Alejandro, Feijge, Marion A.H., Stegner, David, van der Meijden, Paola E.J., Kuijpers, Marijke J.E., Varga-Szabo, David, Heemskerk, Johan W.M., Nieswandt, Bernhard

“…In platelets, STIM1 has been recognized as the key regulatory protein in store-operated Ca2+ entry (SOCE) with Orai1 as principal Ca2+ entry channel. Both…”
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Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation by Gilio, Karen, Munnix, Imke C.A., Mangin, Pierre, Cosemans, Judith M.E.M., Feijge, Marion A.H., van der Meijden, Paola E.J., Olieslagers, Servé, Chrzanowska-Wodnicka, Magdalena B., Lillian, Rivka, Schoenwaelder, Simone, Koyasu, Shigeo, Sage, Stewart O., Jackson, Shaun P., Heemskerk, Johan W.M.

“…Platelets are activated by adhesion to vascular collagen via the immunoglobulin receptor, glycoprotein VI (GPVI). This causes potent signaling toward…”
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Key role of integrin α(IIb)β (3) signaling to Syk kinase in tissue factor-induced thrombin generation by van der Meijden, Paola E J, Feijge, Marion A H, Swieringa, Frauke, Gilio, Karen, Nergiz-Unal, Reyhan, Hamulyák, Karly, Heemskerk, Johan W M

“…The fibrin(ogen) receptor, integrin α(IIb)β(3), has a well-established role in platelet spreading, aggregation and clot retraction. How α(IIb)β(3) contributes…”
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Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen by Gilio, Karen, Harper, Matthew T., Cosemans, Judith M.E.M., Konopatskaya, Olga, Munnix, Imke C.A., Prinzen, Lenneke, Leitges, Michael, Liu, Qinghang, Molkentin, Jeffery D., Heemskerk, Johan W.M., Poole, Alastair W.

“…Arterial thrombosis, a major cause of myocardial infarction and stroke, is initiated by activation of blood platelets by subendothelial collagen. The protein…”
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Key role of integrin αIIbβ₃ signaling to Syk kinase in tissue factor-induced thrombin generation by van der Meijden, Paola E. J, Feijge, Marion A. H, Swieringa, Frauke, Gilio, Karen, Nergiz-Unal, Reyhan, Hamulyák, Karly, Heemskerk, Johan W. M

“…The fibrin(ogen) receptor, integrin αIIbβ₃, has a well-established role in platelet spreading, aggregation and clot retraction. How αIIbβ₃ contributes to…”
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Key role of integrin [alpha]^sub IIb^[beta]^sub 3^ signaling to Syk kinase in tissue factor-induced thrombin generation by van der Meijden, Paola E; J, Feijge, Marion A; H, Swieringa, Frauke, Gilio, Karen, Nergiz-unal, Reyhan, Hamulyák, Karly, Heemskerk, Johan W; M

“…The fibrin(ogen) receptor, integrin α^sub IIb^β^sub 3^, has a well-established role in platelet spreading, aggregation and clot retraction. How α^sub IIb^β^sub…”
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DUSP3 Phosphatase Deficiency or Inhibition Limit Platelet Activation and Arterial Thrombosis by Musumeci, Lucia, Kuijpers, Marijke, Gilio, Karen, Hego, Alexandre, Theatre, Emilie, Maurissen, Lisbeth, Vandereyken, Maud, Diogo, Catia, LECUT, Christelle, Guilmain, William, Bobkova, Ekaterina, Eble, Johannes, Dahl, Russell, Drion, Pierre, Rascon, Justin, Mostofi, Yalda, Yuan, Hongbin, Sergienko, Eduard, Chung, Thomas, Thiry, Marc, Senis, Yotis, MOUTSCHEN, Michel, Mustelin, Tomas, Lancellotti, Patrizio, Heemskerk, Johan, Tautz, Lutz, Oury, Cécile, Rahmouni, Souad

“…Background A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. Better understanding of…”
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Genetic Analysis of the Role of Protein Kinase Cθ in Platelet Function and Thrombus Formation by Hall, Kellie J., Harper, Matthew T., Gilio, Karen, Cosemans, Judith M., Heemskerk, Johan W. M., Poole, Alastair W.

“…Background PKCθ is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCθ−/− T cells exhibit reduced activation and PKCθ−/−…”
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Genetic Analysis of the Role of Protein Kinase C[theta] in Platelet Function and Thrombus Formation by Hall, Kellie J, Harper, Matthew T, Gilio, Karen, Cosemans, Judith M, Heemskerk, Johan W. M, Poole, Alastair W

“…Background PKC[theta] is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKC[theta].sup.-/- T cells exhibit reduced…”
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PKCalpha regulates platelet granule secretion and thrombus formation in mice by Konopatskaya, Olga, Gilio, Karen, Harper, Matthew T, Zhao, Yan, Cosemans, Judith M E M, Karim, Zubair A, Whiteheart, Sidney W, Molkentin, Jeffery D, Verkade, Paul, Watson, Steve P, Heemskerk, Johan W M, Poole, Alastair W

“…Platelets are central players in atherothrombosis development in coronary artery disease. The PKC family provides important intracellular mechanisms for…”
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PKC[alpha] regulates platelet granule secretion and thrombus formation in mice by Konopatskaya, Olga, Gilio, Karen, Harper, Matthew T, Zhao, Yan, Cosemans, Judith M E M, Karim, Zubair A, Whiteheart, Sidney W, Molkentin, Jeffery D, Verkade, Paul, Watson, Steve P, Heemskerk, Johan W M, Poole, Alastair W

“…Platelets are central players in atherothrombosis development in coronary artery disease. The PKC family provides important intracellular mechanisms for…”
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Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation by Karen Gilio, Imke C. A. Munnix, Pierre Mangin, Judith M. E. M. Cosemans, Marion A. H. Feijge, Paola E. J. van der Meijden, Servé Olieslagers, Magdalena B. Chrzanowska-Wodnicka, Rivka Lillian, Simone Schoenwaelder, Shigeo Koyasu, Stewart O. Sage, Shaun P. Jackson, Johan W. M. Heemskerk

“…Platelets are activated by adhesion to vascular collagen via the immunoglobulin receptor, glycoprotein VI (GPVI). This causes potent signaling toward…”
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Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms a and b in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation by Gilio, Karen, Munnix, Imke CA, Mangin, Pierre, Cosemans, Judith MEM, Feijge, Marion AH, Van der Meijden, Paola EJ, Olieslagers, Serve, Chrzanowska-Wodnicka, Magdalena B, Lillian, Rivka, Schoenwaelder, Simone, Koyasu, Shigeo, Sage, Stewart O, Jackson, Shaun P, Heemskerk, Johan WM

“…Platelets are activated by adhesion to vascular collagen via the immunoglobulin receptor, glycoprotein VI (GPVI). This causes potent signaling toward…”
Get full text