Search Results - "Gilham, D E"

Ligation of the CD2 co-stimulatory receptor enhances IL-2 production from first-generation chimeric antigen receptor T cells by Cheadle, E J, Rothwell, D G, Bridgeman, J S, Sheard, V E, Hawkins, R E, Gilham, D E

“…T cells bearing chimeric antigen receptors (CARs) are broadly categorised into first- and second-generation receptors. Second-generation CARs contain a…”
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CD3ζ‐based chimeric antigen receptors mediate T cell activation via cis‐ and trans‐signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy by Bridgeman, J. S., Ladell, K., Sheard, V. E., Miners, K., Hawkins, R. E., Price, D. A., Gilham, D. E.

“…Summary Chimeric antigen receptors (CARs) can mediate redirected lysis of tumour cells in a major histocompatibility complex (MHC)‐independent manner, thereby…”
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Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi‐functional and redirected T cells as effective cancer immunotherapies by Marr, L. A., Gilham, D. E., Campbell, J. D. M., Fraser, A. R.

“…Summary OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Metabolic Diseases, Host Responses, Allergies, Autoinflammatory Diseases, Type 1…”
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Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T-cell-based immunotherapy by GRIFFITHS, R. W, GILHAM, D. E, DANGOOR, A, RAMANI, V, CLARKE, N. W, STERN, P. L, HAWKINS, R. E

“…The 5T4 oncofoetal antigen is a heavily glycosylated cell surface protein found on human placental trophoblast and on diverse types of human cancer but is not…”
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Efficient and reproducible generation of tumour-infiltrating lymphocytes for renal cell carcinoma by Baldan, V, Griffiths, R, Hawkins, R E, Gilham, D E

“…Background: Tumour-infiltrating lymphocyte (TIL) therapy is showing great promise in the treatment of patients with advanced malignant melanoma. However, the…”
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Human monocytes expressing a CEA-specific chimeric CD64 receptor specifically target CEA-expressing tumour cells in vitro and in vivo by BIGLARI, A, SOUTHGATE, T. D, FAIRBAIRN, L. J, GILHAM, D. E

“…Antibody-dependent cellular cytotoxicity (ADCC) is one means by which macrophages (as well as natural killer cells and granulocytes) elicit a cytotoxic…”
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Retroviral transduction of human peripheral blood lymphocytes with bcl-xL promotes in vitro lymphocyte survival in pro-apoptotic conditions by EATON, D, GILHAM, D. E, O'NEILL, A, HAWKINS, R. E

“…The prolonged in vivo survival of genetically modified effector cells is crucial to the success of any (gene-modified) adoptive cellular immunotherapy…”
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Engineering T cells for cancer therapy by MANSOOR, W, GILHAM, D. E, THISTLETHWAITE, F. C, HAWKINS, R. E

“…It is generally accepted that the immune system plays an important role in controlling tumour development. However, the interplay between tumour and immune…”
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Cyclin-dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesis by Coppock, H. A., Gilham, D. E., Howell, A., Clarke, R. B.

“…  Objective: The cyclin‐dependent kinase inhibitors (CDKIs), p21CIP1 and p27KIP1 regulate growth and differentiation in diverse tissue types. We aimed to…”
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T lymphocytes isolated from patients with advanced colorectal cancer are suitable for gene immunotherapy approaches by SHEEN, A. J, SHERLOCK, D. J, LRLAM, J, HAWKINS, R. E, GILHAM, D. E

“…Despite improvements in treatment, the 5-year survival for metastatic colorectal cancer remains poor. Novel approaches such as gene immunotherapy are being…”
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6:  Allosteric Effects of NADPH−Cytochrome P450 Reductase by Modi, S, Gilham, D. E, Sutcliffe, M. J, Lian, L.-Y, Primrose, W. U, Wolf, C. R, Roberts, G. C. K

“…1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin that produces Parkinsonism symptoms in man, has been examined as a substrate of recombinant…”
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Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization by GILHAM, D. E, CAIRNS, W, PAINE, M. J. I, MODI, S, POULSOM, R, ROBERTS, G. C. K, WOLF, C. R

“…1. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a thermal breakdown product of synthetic 'street' heroin, is known to cause Parkinson's Disease-like…”
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Development of adoptive cell therapy for cancer: a clinical perspective by Hawkins, Robert E, Gilham, David E, Debets, Reno, Eshhar, Zelig, Taylor, Naomi, Abken, Hinrich, Schumacher, Ton N, ATTACK Consortium

“…Adoptive cellular therapy provides the promise of a potentially powerful general treatment for cancer. Although this is a complex and challenging field, there…”
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Antibodies: from genes to targeted cancer gene therapy by Hawkins, R E, Whittington, H A, Watkins, S J, Gilham, D E

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Retroviral transduction of human peripheral blood lymphocytes with Bcl-X(L) promotes in vitro lymphocyte survival in pro-apoptotic conditions by Eaton, D, Gilham, D E, O'Neill, A, Hawkins, R E

“…The prolonged in vivo survival of genetically modified effector cells is crucial to the success of any (gene-modified) adoptive cellular immunotherapy…”
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Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli by Pritchard, M P, Glancey, M J, Blake, J A, Gilham, D E, Burchell, B, Wolf, C R, Friedberg, T

“…The polymorphic human CYP2D6 has been co-expressed with human NADPH-cytochrome P450 oxidoreductase in Escherichia coli in order to generate a functional…”
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CD3[zeta]-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy by Bridgeman, J S, Ladell, K, Sheard, V E, Miners, K, Hawkins, R E, Price, D A, Gilham, D E

“…Summary Chimeric antigen receptors (CARs) can mediate redirected lysis of tumour cells in a major histocompatibility complex (MHC)-independent manner, thereby…”
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Cytokine stimulation and the choice of promoter are critical factors for the efficient transduction of mouse T cells with HIV-1 vectors by Gilham, David E., Lie-A-Ling, Michael, Taylor, Naomi, Hawkins, Robert E.

“…Background HIV‐1 fails to successfully infect mouse T cells as a result of several blocks in the viral replication cycle. We investigated whether this also…”
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The role of extracellular spacer regions in the optimal design of chimeric immune receptors: Evaluation of four different scFvs and antigens by GUEST, Ryan D, HAWKINS, Robert E, EMBLETON, M. J, STERN, Peter L, GILHAM, David E, KIRILLOVA, Natalia, CHEADLE, Eleanor J, ARNOLD, Jennifer, O'NEILL, Allison, IRLAM, Joely, CHESTER, Kerry A, KEMSHEAD, John T, SHAW, David M

“…Human peripheral blood lymphocytes can be transduced to express antigen-dependent CD3zeta chimeric immune receptors (CIRs), which function independently of the…”
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O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy by Verbeek, Barbara, Southgate, Thomas D., Gilham, David E., Margison, Geoffrey P.

“…Introduction Alkylating agents are frequently used in the chemotherapy of many types of cancer. This group of drugs mediates cell death by damaging DNA and…”
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