Search Results - "Gilger, Brian C"

Therapeutic Applications of Adeno-Associated Virus (AAV) Gene Transfer of HLA-G in the Eye by Gilger, Brian C, Hirsch, Matthew L

“…The purpose of this paper is to review human leukocyte antigen G (HLA-G) in the eye, its role in immune tolerance, and the potential therapeutic use of AAV…”
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Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles by Tsujinaka, Hiroki, Fu, Jie, Shen, Jikui, Yu, Yun, Hafiz, Zibran, Kays, Joshua, McKenzie, David, Cardona, Delia, Culp, David, Peterson, Ward, Gilger, Brian C., Crean, Christopher S., Zhang, Jin-Zhong, Kanan, Yogita, Yu, Weiling, Cleland, Jeffrey L., Yang, Ming, Hanes, Justin, Campochiaro, Peter A.

“…Neovascular age-related macular degeneration and diabetic retinopathy are prevalent causes of vision loss requiring frequent intravitreous injections of…”
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Adeno-Associated Virus Mediated Gene Therapy for Corneal Diseases by Bastola, Prabhakar, Song, Liujiang, Gilger, Brian C., Hirsch, Matthew L.

“…According to the World Health Organization, corneal diseases are the fourth leading cause of blindness worldwide accounting for 5.1% of all ocular…”
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Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy by Crabtree, Elizabeth, Uribe, Katy, Smith, Sara M, Roberts, Darby, Salmon, Jacklyn H, Bower, Jacquelyn J, Song, Liujiang, Bastola, Prabhakar, Hirsch, Matthew L, Gilger, Brian C

“…Equine recurrent uveitis (ERU) is a spontaneous, painful, and vision threatening disease affecting up to 25% of equine populations worldwide. Current…”
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Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro by Sherman, Amanda B, Gilger, Brian C, Berglund, Alix K, Schnabel, Lauren V

“…We aimed to determine and compare the in vitro effects of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) and mesenchymal stem cell supernatant…”
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Multi-locus DNA sequence analysis, antifungal agent susceptibility, and fungal keratitis outcome in horses from Southeastern United States by Cullen, Megan, Jacob, Megan E, Cornish, Vicki, VanderSchel, Ian Q, Cotter, Henry Van T, Cubeta, Marc A, Carbone, Ignazio, Gilger, Brian C

“…Morphological characterization and multi-locus DNA sequence analysis of fungal isolates obtained from 32 clinical cases of equine fungal keratitis (FK) was…”
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A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs by Meurs, Kathryn M, Montgomery, Keith, Friedenberg, Steven G, Williams, Brian, Gilger, Brian C

“…Abstract Background Superficial chronic corneal epithelial defects (SCCEDs) are spontaneous corneal defects in dogs that share many clinical and pathologic…”
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Phase-Dependent Differential In Vitro and Ex Vivo Susceptibility of Aspergillus flavus and Fusarium keratoplasticum to Azole Antifungals by Roberts, Darby, Salmon, Jacklyn, Cubeta, Marc A, Gilger, Brian C

“…Fungal keratitis (FK) is an invasive infection of the cornea primarily associated with and species. FK is treated empirically with a limited selection of…”
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How study of naturally occurring ocular disease in animals improves ocular health globally by Gilger, Brian C.

“…Abstract In this article, which is part of the Currents in One Health series, the role of naturally occurring ocular disease in animals is reviewed with…”
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AAV-mediated expression of HLA-G for the prevention of experimental ocular graft vs. host disease by Nilles, Jacob P., Roberts, Darby, Salmon, Jacklyn H., Song, Liujiang, O’Dea, Carly, Marjoram, Lindsay T., Bower, Jacquelyn J., Hirsch, Matthew L., Gilger, Brian C.

“…Ocular graft versus host disease (OGvHD) develops after allogeneic hematopoietic stem cell transplantation (HSCT) and manifests as ocular surface inflammatory…”
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Developing advanced therapeutics through the study of naturally occurring immune-mediated ocular disease in domestic animals by Gilger, Brian C

“…This review, which is part of the "Currents in One Health" series, describes the importance of the study of immune-mediated ocular disease in the development…”
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Ocular Tolerability and Immune Response to Corneal Intrastromal AAV-IDUA Gene Therapy in New Zealand White Rabbits by Song, Liujiang, Bower, Jacquelyn J., Llanga, Telmo, Salmon, Jacklyn H., Hirsch, Matthew L., Gilger, Brian C.

“…The chronic ocular toxicity, tolerability, and inflammation following corneal intrastromal injection of saline or escalating doses of an adeno-associated virus…”
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Solving an eye condition by looking to the rear by Gilger, Brian C.

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Current therapy and advancements in the treatment of equine fungal keratitis by Roberts, Darby M, Gilger, Brian C

“…Equine fungal keratitis represents a substantial portion of keratitis cases in horses, with fungal involvement identified in approximately half of all…”
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Immune Relevant Models for Ocular Inflammatory Diseases by Gilger, Brian C

“…Ocular inflammatory diseases, such as dry eye and uveitis, are common, painful, difficult to treat, and may result in vision loss or blindness. Ocular side…”
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Treatment of acute posterior uveitis in a porcine model by injection of triamcinolone acetonide into the suprachoroidal space using microneedles by Gilger, Brian C, Abarca, Eva M, Salmon, Jacklyn H, Patel, Samirkumar

“…To evaluate the effect of triamcinolone acetonide (TA) administered into the suprachoroidal space (SCS) using a microneedle and compare it with intravitreal…”
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Cold atmospheric plasma inactivates Aspergillus flavus and Fusarium keratoplasticum biofilms and conidia in vitro by Roberts, Darby, Thomas, Jonathan, Salmon, Jacklyn, Cubeta, Marc A, Stapelmann, Katharina, Gilger, Brian C

“…and are common causative pathogens of fungal keratitis (FK), a severe corneal disease associated with significant morbidity and vision loss. Escalating…”
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Topical delivery of aqueous micellar resolvin E1 analog (RX-10045) by Cholkar, Kishore, Gilger, Brian C., Mitra, Ashim K.

“…[Display omitted] The primary objective of this study were to optimize aqueous micellar solution of isopropyl ester prodrug of resolvin (RX-10045), study in…”
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Treatment of equine keratomycosis, part 1: selection of appropriate therapy based on clinical presentation and diagnostic testing improves clinical outcomes by Smith, Hannah L, Love, Kim R, Antezana, Ariana, Barr, Erin M, Gilger, Brian C, Oh, Annie

“…To determine clinical outcome, treatment costs, and hospitalization duration in horses treated for keratomycosis and identify ophthalmic examination and…”
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Serotype survey of AAV gene delivery via subconjunctival injection in mice by Song, Liujiang, Llanga, Telmo, Conatser, Laura M., Zaric, Violeta, Gilger, Brian C., Hirsch, Matthew L.

“…AAV gene therapy approaches in the posterior eye resulted in the first FDA-approved gene therapy-based drug. However, application of AAV vectorology to the…”
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