Search Results - "Giles, W R"

K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts by Chilton, L, Ohya, S, Freed, D, George, E, Drobic, V, Shibukawa, Y, Maccannell, K A, Imaizumi, Y, Clark, R B, Dixon, I M C, Giles, W R

“…Despite the important roles played by ventricular fibroblasts and myofibroblasts in the formation and maintenance of the extracellular matrix, neither the…”
Get more information

The zebrafish atrioventricular canal: A model for mammalian AV node conduction and secondary or follower pacemaker activity by Giles, W. R.

Get full text

C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling by Rose, R. A., Hatano, N., Ohya, S., Imaizumi, Y., Giles, W. R.

“…In the heart, fibroblasts play an essential role in the deposition of the extracellular matrix and they also secrete a number of hormonal factors. Although…”
Get full text

Mathematical Model of an Adult Human Atrial Cell: The Role of K+ Currents in Repolarization by Nygren, A, Fiset, C, Firek, L, Clark, J.W, Lindblad, D.S, Clark, R.B

“…We have developed a mathematical model of the human atrial myocyte based on averaged voltage-clamp data recorded from isolated single myocytes. Our model…”
Get full text

Increases in dietary phosphate levels can augment atrial arrhythmias by Ganesan, P., Narayan, S. M., Giles, W. R.

Get full text

Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cells by Cordeiro, J. M., Spitzer, K. W., Giles, W. R., Ershler, P. E., Cannell, M. B., Bridge, J. H. B.

“…The distribution and localization of Ca 2+ transients and Ca 2+ sparks in isolated adult rabbit Purkinje cells were examined using confocal microscopy and the…”
Get full text

Voltage-sensitive dye mapping in Langendorff-perfused rat hearts by Nygren, A, Kondo, C, Clark, R B, Giles, W R

“…An imaging system suitable for recordings from Langendorff-perfused rat hearts using the voltage-sensitive dye…”
Get more information

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing by Quinn, T.A., Granite, S., Allessie, M.A., Antzelevitch, C., Bollensdorff, C., Bub, G., Burton, R.A.B., Cerbai, E., Chen, P.S., Delmar, M., DiFrancesco, D., Earm, Y.E., Efimov, I.R., Egger, M., Entcheva, E., Fink, M., Fischmeister, R., Franz, M.R., Garny, A., Giles, W.R., Hannes, T., Harding, S.E., Hunter, P.J., Iribe, G., Jalife, J., Johnson, C.R., Kass, R.S., Kodama, I., Koren, G., Lord, P., Markhasin, V.S., Matsuoka, S., McCulloch, A.D., Mirams, G.R., Morley, G.E., Nattel, S., Noble, D., Olesen, S.P., Panfilov, A.V., Trayanova, N.A., Ravens, U., Richard, S., Rosenbaum, D.S., Rudy, Y., Sachs, F., Sachse, F.B., Saint, D.A., Schotten, U., Solovyova, O., Taggart, P., Tung, L., Varró, A., Volders, P.G., Wang, K., Weiss, J.N., Wettwer, E., White, E., Wilders, R., Winslow, R.L., Kohl, P.

“…Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As…”
Get full text

A model of the action potential and underlying membrane currents in a rabbit atrial cell by Lindblad, D S, Murphey, C R, Clark, J W, Giles, W R

“…We have developed a mathematical model of the rabbit atrial myocyte and have used it in an examination of the ionic basis of the atrial action potential…”
Get full text

An obligatory role for nitric oxide in autonomic control of mammalian heart rate by Han, X, Shimoni, Y, Giles, W R

“…Cholinergic modulation of heart rate in isolated spontaneously beating single cells from the rabbit sino-atrial node was investigated by measuring…”
Get full text

Repolarizing K+ currents in rabbit heart Purkinje cells by Cordeiro, J. M., Spitzer, K. W., Giles, W. R.

“…Electrophysiological experiments on single myocytes obtained from Purkinje fibres and ventricular tissue of adult rabbit hearts were done to compare the…”
Get full text

Blockade of KATP Channels Reduces Endothelial Hyperpolarization and Leukocyte Recruitment upon Reperfusion After Hypoxia by Figura, M., Chilton, L., Liacini, A., Viskovic, M. Maric, Phan, V., Knight, D., Millar, T. M., Patel, K., Kubes, P., Giles, W. R., Tibbles, L. A.

“…Ischemia/reperfusion injury in renal transplantation leads to slow or initial nonfunction, and predisposes to acute and chronic rejection. In fact, severe…”
Get full text

A rapidly activating sustained K+ current modulates repolarization and excitation-contraction coupling in adult mouse ventricle by Fiset, C., Clark, R. B., Larsen, T. S., Giles, W. R.

“…1. The K+ currents which control repolarization in adult mouse ventricle, and the effects of changes in action potential duration on excitation-contraction…”
Get full text

Spatiotemporal evolution of ventricular fibrillation by Witkowski, Francis X, Leon, L. Joshua, Penkoske, Patricia A, Giles, Wayne R, Spano, Mark L, Ditto, William L, Winfree, Arthur T

“…Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation…”
Get full text

Novel regulation of the mammalian cardiac Na+ channel by dipeptidyl peptidase 10 interactions: An editorial comment by Ni, H., Rajamani, S., Giles, W.R.

Get full text

Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle by Fedida, D, Giles, W R

“…1. Regional variations in the shape of early repolarization of the action potential have been correlated to differences in transient outward K+ current, I(t),…”
Get full text

Inhibition of L-type Ca2+ current by C-type natriuretic peptide in bullfrog atrial myocytes: an NPR-C-mediated effect by Rose, R A, Lomax, A E, Giles, W R

“…Single atrial myocytes were isolated from the bullfrog heart and studied under current and voltage clamp conditions to determine the electrophysiological…”
Get more information

Comparison of potassium currents in rabbit atrial and ventricular cells by Giles, W R, Imaizumi, Y

“…1. In rabbit and human hearts there are significant differences in the action potential configuration in atrium and ventricle, and the action potential…”
Get full text

Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes by Ward, C A, Giles, W R

“…1. Whole-cell and amphotericin-perforated patch-clamp techniques have been used to study the effects of hydrogen peroxide (H2O2) on action potentials and…”
Get full text

Effects of Action Potential Duration on Excitation-Contraction Coupling in Rat Ventricular Myocytes: Action Potential Voltage-Clamp Measurements by Bouchard, R.A, Clark, R.B, Giles, W.R

“…Although each of the fundamental processes involved in excitation-contraction coupling in mammalian heart has been identified, many quantitative details remain…”
Get full text