Search Results - "Giles, Peter J."

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal by Rosas, Marcela, Davies, Luke C., Giles, Peter J., Liao, Chia-Te, Kharfan, Bashar, Stone, Timothy C., O'Donnell, Valerie B., Fraser, Donald J., Jones, Simon A., Taylor, Philip R.

“…Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche–specific functions. Many populations self-renew independently of bone marrow…”
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Proteomics Analysis of Bladder Cancer Exosomes by Welton, Joanne L., Khanna, Sanjay, Giles, Peter J., Brennan, Paul, Brewis, Ian A., Staffurth, John, Mason, Malcolm D., Clayton, Aled

“…Exosomes are nanometer-sized vesicles, secreted by various cell types, present in biological fluids that are particularly rich in membrane proteins. Ex vivo…”
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Sensitivity to inhibition of DNA repair by Olaparib in novel oropharyngeal cancer cell lines infected with Human Papillomavirus by Pirotte, Evelyne F, Holzhauser, Stefan, Owens, David, Quine, Stuart, Al-Hussaini, Ali, Christian, Adam D, Giles, Peter J, Man, Stephen T, Evans, Mererid, Powell, Ned G

“…The incidence of Human Papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing rapidly in the UK. Patients with…”
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IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation by Liao, Chia‐Te, Rosas, Marcela, Davies, Luke C., Giles, Peter J., Tyrrell, Victoria J., O'Donnell, Valerie B., Topley, Nicholas, Humphreys, Ian R., Fraser, Donald J., Jones, Simon A., Taylor, Philip R.

“…The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and…”
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Microarray analysis of senescent vascular smooth muscle cells: A link to atherosclerosis and vascular calcification by Burton, Dominick G.A., Giles, Peter J., Sheerin, Angela N.P., Smith, S. Kaye, Lawton, Jessica J., Ostler, Elizabeth L., Rhys-Williams, William, Kipling, David, Faragher, Richard G.A.

“…Little is known about the senescent phenotype of human vascular smooth muscle cells (VSMCs) and the potential involvement of senescent VSMCs in age-related…”
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Identification of a transcriptional signature for the wound healing continuum by Peake, Matthew A., Caley, Mathew, Giles, Peter J., Wall, Ivan, Enoch, Stuart, Davies, Lindsay C., Kipling, David, Thomas, David W., Stephens, Phil

“…There is a spectrum/continuum of adult human wound healing outcomes ranging from the enhanced (nearly scarless) healing observed in oral mucosa to scarring…”
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Role of Enzymic Antioxidants in Mediating Oxidative Stress and Contrasting Wound Healing Capabilities in Oral Mucosal/Skin Fibroblasts and Tissues by Lohana, Parkash, Suryaprawira, Albert, Woods, Emma L, Dally, Jordanna, Gait-Carr, Edward, Alaidaroos, Nadia Y A, Heard, Charles M, Lee, Kwok Y, Ruge, Fiona, Farrier, Jeremy N, Enoch, Stuart, Caley, Matthew P, Peake, Matthew A, Davies, Lindsay C, Giles, Peter J, Thomas, David W, Stephens, Phil, Moseley, Ryan

“…Unlike skin, oral mucosal wounds are characterized by rapid healing and minimal scarring, attributable to the "enhanced" healing properties of oral mucosal…”
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Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers by Lewis, Thomas, Corcoran, David B, Thurston, David E, Giles, Peter J, Ashelford, Kevin, Walsby, Elisabeth J, Fegan, Christopher D, Pepper, Andrea G S, Miraz Rahman, Khondaker, Pepper, Chris

“…Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB…”
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Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death by Johnson, Charlotte E., Dunlop, Elaine A., Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J., Jones, Ashley T., Giles, Peter J., Shen, Ming H., Sampson, Julian R., Errington, Rachel J., Davies, D. Mark, Tee, Andrew R.

“…Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis…”
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Correction: Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir–bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death by Johnson, Charlotte E., Dunlop, Elaine A., Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J., Jones, Ashley T., Giles, Peter J., Shen, Ming H., Sampson, Julian R., Errington, Rachel J., Davies, D. Mark, Tee, Andrew R.

“…This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper…”
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Normality of oligonucleotide microarray data and implications for parametric statistical analyses by Giles, Peter J., Kipling, David

“…Motivation: Experimental limitations have resulted in the popularity of parametric statistical tests as a method for identifying differentially regulated genes…”
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Cyclin D1 Overexpression Permits the Reproducible Detection of Senescent Human Vascular Smooth Muscle Cells by BURTON, DOMINICK G. A., SHEERIN, ANGELA N., OSTLER, ELIZABETH L., SMITH, KAYE, GILES, PETER J., LOWE, JILL, RHYS-WILLIAMS, WILLIAM, KIPLING, DAVID G., FARAGHER, RICHARD G. A.

“…:  The senescence of mitotic cells is hypothesized to play a causal role in organismal aging. Cultures of normal human cells become senescent in vitro as a…”
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A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: The effects of growth, quiescence and senescence by Kipling, David, Jones, Dawn L., Smith, S. Kaye, Giles, Peter J., Jennert-Burston, Katrin, Ibrahim, Badr, Sheerin, Angela N.P., Evans, Amy J.C., Rhys-Willams, William, Faragher, Richard G.A.

“…There is a growing need within ocular research for well-defined cellular models of normal corneal biology. To meet this need we created and partially…”
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Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit nuclear factor-κB activity and synergize with bortezomib and ibrutinib in hematologic cancers by Lewis, Thomas, Corcoran, David B., Thurston, David E., Giles, Peter J., Ashelford, Kevin, Walsby, Elisabeth J., Fegan, Christopher D., Pepper, Andrea G. S., Rahman, Khondaker Miraz, Pepper, Chris

“…Chronic lymphocytic leukemia (CLL) and multiple myeloma are incurable hematologic malignancies that are pathologically linked with aberrant nuclear…”
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