Search Results - "Giles, Niroshini M."

Sulfur and Selenium: The Role of Oxidation State in Protein Structure and Function by Jacob, Claus, Giles, Gregory I., Giles, Niroshini M., Sies, Helmut

“…Sulfur and selenium occur in proteins as constituents of the amino acids cysteine, methionine, selenocysteine, and selenomethionine. Recent research…”
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Redox catalysts as sensitisers towards oxidative stress by Giles, Niroshini M, Gutowski, Nick J, Giles, Gregory I, Jacob, Claus

“…The predominance of oxidative stress in many tumour cell environments provides a means to selectively target these cells via protein oxidation. The zinc…”
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Multifunctional redox catalysts as selective enhancers of oxidative stress by Fry, Fiona H, Holme, Andrea L, Giles, Niroshini M, Giles, Gregory I, Collins, Catriona, Holt, Kim, Pariagh, Sandra, Gelbrich, Thomas, Hursthouse, Michael B, Gutowski, Nick J, Jacob, Claus

“…Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these…”
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Quadruply Stranded Metallo-Supramolecular Helicate [Pd2(hextrz)4]4+ Acts as a Molecular Mimic of Cytolytic Peptides by McNeill, Samantha M, Giles, Niroshini M, Preston, Dan, Jones, Peter P, Crowley, James D, Giles, Gregory I

“…[Pd2(hextrz)4]4+ is a quadruply stranded helicate, a novel bioinorganic complex designed to mimic the structure and function of proteins due to its high…”
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The Use of Styrene Maleic Acid Nanomicelles Encapsulating the Synthetic Cannabinoid Analog WIN55,212-2 for the Treatment of Cancer by Xian, Susan, Parayath, Neha N, Nehoff, Hayley, Giles, Niroshini M, Greish, Khaled

“…Synthetic cannabinoid WIN55,212-2 (WIN) has shown a promise as an anticancer agent but causes psychoactive side-effects. In the present study, nano-micelles of…”
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Multiple roles of cysteine in biocatalysis by Giles, Niroshini M, Giles, Gregory I, Jacob, Claus

“…In biology, sulfur frequently occurs in the form of cysteine, an amino acid that fulfills a wide range of different functions in proteins including disulfide…”
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A hydrogen peroxide electrode assay to measure thiol peroxidase activity for organoselenium and organotellurium drugs by Giles, Niroshini M., Kumari, Sweta, Stamm, Rosemary A., Patel, Siddharth, Giles, Gregory I.

“…Molecular mimics of the enzyme glutathione peroxidase (GPx) are increasingly being evaluated as redox active drugs. Their molecular mechanism of action…”
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Intracellular Targeting and Pharmacological Activity of the Superoxide Dismutase Mimics MnTE-2-PyP5+ and MnTnHex-2-PyP5+ Regulated by Their Porphyrin Ring Substituents by Aitken, Jade B, Shearer, Emily L, Giles, Niroshini M, Lai, Barry, Vogt, Stefan, Reboucas, Julio S, Batinic-Haberle, Ines, Lay, Peter A, Giles, Gregory I

“…Manganese porphyrin-based drugs are potent mimics of the enzyme superoxide dismutase. They exert remarkable efficacy in disease models and are entering…”
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The Molecular Design of S-Nitrosothiols as Photodynamic Agents for Controlled Nitric Oxide Release by Giles, Niroshini M., Kumari, Sweta, Gang, Bevan P., Yuen, Chun W. W., Billaud, Emilie M. F., Giles, Gregory I.

“…Nitric oxide is a small messenger molecule utilized by nature in cell signalling and the non‐specific immune response. At present, nitric oxide releasing…”
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A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress by Landar, Aimee, Oh, Joo-Yeun, Giles, Niroshini M., Isom, Amanda, Kirk, Marion, Barnes, Stephen, Darley-Usmar, Victor M.

“…The combination of proteomics with highly specific and sensitive affinity techniques is important for the identification of posttranslational modifications by…”
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Reactive sulphur species: an in vitro investigation of the oxidation properties of disulphide S-oxides by Giles, Gregory I, Tasker, Karen M, Collins, Catriona, Giles, Niroshini M, O'rourke, Elizabeth, Jacob, Claus

“…We have recently proposed that disulphide S-monoxides (thiosulphinates) and disulphide S-dioxides (thiosulphonates) are formed from their parent disulphides…”
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Electrochemical, in vitro and cell culture analysis of integrated redox catalysts: implications for cancer therapy by Giles, Gregory I, Giles, Niroshini M, Collins, Catriona A, Holt, Kim, Fry, Fiona H, Lowden, Philip A S, Gutowski, Nicholas J, Jacob, Claus

“…Integrated catalysts as redox sensitisers towards cancer…”
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Targeting oxidative stress-related diseases: organochalcogen catalysts as redox sensitizers by Giles, Niroshini M, Giles, Gregory I, Holley, Janet E, Gutowski, Nick J, Jacob, Claus

“…Tumor cells proliferate under conditions of oxidative stress. A novel therapeutic approach would be to enhance the cellular effects of the reactive oxygen…”
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Metal and Redox Modulation of Cysteine Protein Function by Giles, Niroshini M, Watts, Aaron B, Giles, Gregory I, Fry, Fiona H, Littlechild, Jennifer A, Jacob, Claus

“…In biological systems, the amino acid cysteine combines catalytic activity with an extensive redox chemistry and unique metal binding properties. The…”
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Intracellular Targeting and Pharmacological Activity of the Superoxide Dismutase Mimics MnTE-2-PyP 5+ and MnTnHex-2-PyP 5+ Regulated by Their Porphyrin Ring Substituents by Aitken, Jade B., Shearer, Emily L., Giles, Niroshini M., Lai, Barry, Vogt, Stefan, Reboucas, Julio S., Batinic-Haberle, Ines, Lay, Peter A., Giles, Gregory I.

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Schwefel und Selen: Bedeutung der Oxidationsstufe für Struktur und Funktion von Proteinen by Jacob, Claus, Giles, Gregory I., Giles, Niroshini M., Sies, Helmut

“…Schwefel und Selen kommen in Proteinen als Bestandteile der Aminosäuren Cystein, Methionin, Selenocystein und Selenomethionin vor, deren Ausnahmestellung in…”
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