Search Results - "Giles, Jon"

Extra-articular Manifestations and Comorbidity in Rheumatoid Arthritis: Potential Impact of Pre–Rheumatoid Arthritis Prevention by Giles, Jon T.

“…Rheumatoid arthritis (RA) is associated with a wide variety of extra-articular manifestations and comorbidities, several of which can be organ- or even…”
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Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions by Raggi, Paolo, Genest, Jacques, Giles, Jon T., Rayner, Katey J., Dwivedi, Girish, Beanlands, Robert S., Gupta, Milan

“…Rudolph Virchow (1821–1902) recognized inflammation in histological preparations of coronary arteries and proposed that inflammation plays a causal role in…”
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Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical phenotype by FitzGerald, Oliver, Haroon, Muhammad, Giles, Jon T, Winchester, Robert

“…This review focuses on the genetic features of psoriatic arthritis (PsA) and their relationship to phenotypic heterogeneity in the disease, and addresses three…”
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PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets by Curran, Ashley M., Naik, Pooja, Giles, Jon T., Darrah, Erika

“…Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of rheumatoid arthritis (RA) owing to their ability to generate citrullinated…”
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Cardiovascular Safety of Tocilizumab Versus Etanercept in Rheumatoid Arthritis: A Randomized Controlled Trial by Giles, Jon T., Sattar, Naveed, Gabriel, Sherine, Ridker, Paul M., Gay, Steffen, Warne, Charles, Musselman, David, Brockwell, Laura, Shittu, Emma, Klearman, Micki, Fleming, Thomas R.

“…Objective To assess the risk of major adverse cardiovascular events (MACE) in patients with rheumatoid arthritis (RA) treated with tocilizumab compared to…”
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Shared inflammatory pathways of rheumatoid arthritis and atherosclerotic cardiovascular disease by Weber, Brittany N., Giles, Jon T., Liao, Katherine P.

“…The association between chronic inflammation and increased risk of cardiovascular disease in rheumatoid arthritis (RA) is well established. In the general…”
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Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis by Konig, Maximilian F, Abusleme, Loreto, Reinholdt, Jesper, Palmer, Robert J, Teles, Ricardo P, Sampson, Kevon, Rosen, Antony, Nigrovic, Peter A, Sokolove, Jeremy, Giles, Jon T, Moutsopoulos, Niki M, Andrade, Felipe

“…A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as…”
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Certain class I HLA alleles and haplotypes implicated in susceptibility play a role in determining specific features of the psoriatic arthritis phenotype by Haroon, Muhammad, Winchester, Robert, Giles, Jon T, Heffernan, Eric, FitzGerald, Oliver

“…Psoriatic arthritis (PsA) susceptibility is associated with several different class I alleles, suggesting separate patterns of MHC effect. This exploratory…”
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Risk of major adverse cardiovascular events with tofacitinib versus tumour necrosis factor inhibitors in patients with rheumatoid arthritis with or without a history of atherosclerotic cardiovascular disease: a post hoc analysis from ORAL Surveillance by Charles-Schoeman, Christina, Buch, Maya H, Dougados, Maxime, Bhatt, Deepak L, Giles, Jon T, Ytterberg, Steven R, Koch, Gary G, Vranic, Ivana, Wu, Joseph, Wang, Cunshan, Kwok, Kenneth, Menon, Sujatha, Rivas, Jose L, Yndestad, Arne, Connell, Carol A, Szekanecz, Zoltan

“…Evaluate risk of major adverse cardiovascular events (MACE) with tofacitinib versus tumour necrosis factor inhibitors (TNFi) in patients with rheumatoid…”
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On Needles and Haystacks: The Perils of Cardiovascular Risk Screening in Rheumatoid Arthritis by Giles, Jon T

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Associations of Antibodies Targeting Periodontal Pathogens With Subclinical Coronary, Carotid, and Peripheral Arterial Atherosclerosis in Rheumatoid Arthritis by Giles, Jon T., Reinholdt, Jesper, Andrade, Felipe, Konig, Maximilian F.

“…Objective Both periodontal disease and cardiovascular disease (CVD) are overrepresented in rheumatoid arthritis (RA). This study was undertaken to investigate…”
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Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis by Darrah, Erika, Rosen, Antony, Giles, Jon T, Andrade, Felipe

“…To define the relationship between autoantigen citrullination and different peptidylarginine deiminase (PAD) enzymes in rheumatoid arthritis (RA)…”
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Axial Disease in Psoriatic Arthritis study: defining the clinical and radiographic phenotype of psoriatic spondyloarthritis by Jadon, Deepak R, Sengupta, Raj, Nightingale, Alison, Lindsay, Mark, Korendowych, Eleanor, Robinson, Graham, Jobling, Amelia, Shaddick, Gavin, Bi, Jing, Winchester, Robert, Giles, Jon T, McHugh, Neil J

“…To compare the prevalence, clinical and radiographic characteristics of psoriatic spondyloarthritis (PsSpA) in psoriatic arthritis (PsA), with ankylosing…”
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Cardiovascular disease in rheumatoid arthritis: Current perspectives on assessing and mitigating risk in clinical practice by Giles, Jon T

“…Abstract That individuals with rheumatoid arthritis (RA) have, on average, higher rates of events related to atherosclerotic vascular disease is now well…”
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Use of methotrexate and TNF inhibitors in patients with rheumatoid arthritis–associated interstitial lung disease: a survey of rheumatologists by Park, Elizabeth, Iqbal, Rabia, Giles, Jon T., Bernstein, Elana J.

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Left ventricular remodeling in rheumatoid arthritis patients without clinical heart failure by Park, Elizabeth, Ito, Kazato, Depender, Christopher, Giles, Jon T, Bathon, Joan

“…Rheumatoid arthritis (RA) patients have a 1.5- to twofold higher risk of developing heart failure (HF) and a twofold increased risk of HF-associated mortality…”
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Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study by McInnes, Iain B, Thompson, Liz, Giles, Jon T, Bathon, Joan M, Salmon, Jane E, Beaulieu, Andre D, Codding, Christine E, Carlson, Timothy H, Delles, Christian, Lee, Janet S, Sattar, Naveed

“…The interleukin-6 receptor (IL-6R) blocker tocilizumab (TCZ) reduces inflammatory disease activity in rheumatoid arthritis (RA) but elevates lipid…”
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Heart Rate-corrected QT Interval Duration in Rheumatoid Arthritis and Its Reduction with Treatment with the Interleukin 6 Inhibitor Tocilizumab by Kobayashi, Hitomi, Kobayashi, Yasuyuki, Yokoe, Isamu, Kitamura, Noboru, Nishiwaki, Atsuma, Takei, Masami, Giles, Jon T

“…Individuals with rheumatoid arthritis (RA) are at a heightened risk of sudden cardiac death, an outcome increased in those with prolongation of the corrected…”
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Getting personal: towards individualized management of rheumatoid arthritis by Giles, Jon T

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Prophylaxis Against COVID‐19 With Hydroxychloroquine and Chloroquine: Comment on the Article by Putman et al by Tang, Wei, Gartshteyn, Yevgeniya, Guo, Cathy, Chen, Tommy, Giles, Jon, Askanase, Anca

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