Search Results - "Giles, H H"

The genetics of obesity: from discovery to biology by Loos, Ruth J. F., Yeo, Giles S. H.

“…The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare,…”
Get full text

European Association of Urology Guidelines on Renal Cell Carcinoma: The 2022 Update by Ljungberg, Börje, Albiges, Laurence, Abu-Ghanem, Yasmin, Bedke, Jens, Capitanio, Umberto, Dabestani, Saeed, Fernández-Pello, Sergio, Giles, Rachel H., Hofmann, Fabian, Hora, Milan, Klatte, Tobias, Kuusk, Teele, Lam, Thomas B., Marconi, Lorenzo, Powles, Thomas, Tahbaz, Rana, Volpe, Alessandro, Bex, Axel

“…The 2022 guideline provides the current best evidence base for renal cell carcinoma management. Changes in medical management in recent years include the use…”
Get full text

European Association of Urology Guidelines on Renal Cell Carcinoma: The 2019 Update by Ljungberg, Börje, Albiges, Laurance, Abu-Ghanem, Yasmin, Bensalah, Karim, Dabestani, Saeed, Fernández-Pello, Sergio, Giles, Rachel H., Hofmann, Fabian, Hora, Milan, Kuczyk, Markus A., Kuusk, Teele, Lam, Thomas B., Marconi, Lorenzo, Merseburger, Axel S., Powles, Thomas, Staehler, Michael, Tahbaz, Rana, Volpe, Alessandro, Bex, Axel

“…The European Association of Urology Renal Cell Carcinoma (RCC) Guideline Panel has prepared evidence-based guidelines and recommendations for the management of…”
Get full text

Total and State-Specific Medical and Absenteeism Costs of COPD Among Adults Aged 18 Years in the United States for 2010 and Projections Through 2020 by Ford, Earl S., MD, MPH, Murphy, Louise B., PhD, Khavjou, Olga, MA, Giles, Wayne H., MD, Holt, James B., PhD, Croft, Janet B., PhD

“…BACKGROUND COPD remains a leading cause of morbidity and mortality. The objectives of this study were to estimate (1) national US COPD-attributable annual…”
Get full text

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets by Adriaenssens, Alice E., Svendsen, Berit, Lam, Brian Y. H., Yeo, Giles S. H., Holst, Jens J., Reimann, Frank, Gribble, Fiona M.

“…Aims/hypothesis Intra-islet and gut–islet crosstalk are critical in orchestrating basal and postprandial metabolism. The aim of this study was to identify…”
Get full text

Using Bayesian networks to examine consistent trends in fish farm benthic impact studies by Giles, H.

“…Fish farming in coastal marine environments results in the deposition of waste products on the seafloor and can cause changes in sediment chemistry and…”
Get full text

Breaking our daily "ultra-processed" bread by Yeo, Giles S H

“…In the Editorial, Giles Yeo discusses if it is possible that the UPF concept could be doing more harm than good…”
Get full text

The bigger picture of FTO—the first GWAS-identified obesity gene by Loos, Ruth J. F., Yeo, Giles S. H.

“…Key Points A cluster of single nucleotide polymorphisms (SNPs) in intron 1 of fat mass and obesity associated ( FTO ) gene was the first obesity susceptibility…”
Get full text

Updated European Association of Urology Guidelines on Renal Cell Carcinoma: Immune Checkpoint Inhibition Is the New Backbone in First-line Treatment of Metastatic Clear-cell Renal Cell Carcinoma by Albiges, Laurence, Powles, Tom, Staehler, Michael, Bensalah, Karim, Giles, Rachel H., Hora, Milan, Kuczyk, Markus A., Lam, Thomas B., Ljungberg, Börje, Marconi, Lorenzo, Merseburger, Axel S., Volpe, Alessandro, Abu-Ghanem, Yasmin, Dabestani, Saeed, Fernández-Pello, Sergio, Hofmann, Fabian, Kuusk, Teele, Tahbaz, Rana, Bex, Axel

“…Recent randomised trials have demonstrated a survival benefit for a front-line ipilimumab and nivolumab combination therapy, and pembrolizumab and axitinib…”
Get full text

Unraveling the brain regulation of appetite: lessons from genetics by Yeo, Giles S H, Heisler, Lora K

“…This review discusses what we have learned about the neural regulation of feeding from genetic studies, both from studies in mutant mice and more recent…”
Get full text

Updated European Association of Urology Guidelines on Renal Cell Carcinoma: Nivolumab plus Cabozantinib Joins Immune Checkpoint Inhibition Combination Therapies for Treatment-naïve Metastatic Clear-Cell Renal Cell Carcinoma by Bedke, Jens, Albiges, Laurence, Capitanio, Umberto, Giles, Rachel H., Hora, Milan, Lam, Thomas B., Ljungberg, Börje, Marconi, Lorenzo, Klatte, Tobias, Volpe, Alessandro, Abu-Ghanem, Yasmin, Dabestani, Saeed, Fernández-Pello, Sergio, Hofmann, Fabian, Kuusk, Teele, Tahbaz, Rana, Powles, Thomas, Bex, Axel

“…Longer follow-up and new trial data from phase 3 randomised controlled trials investigating immune checkpoint blockade (PD-1 or its ligand PD-L1) in advanced…”
Get full text

Is calorie labelling on menus the solution to obesity? by Yeo, Giles S. H.

“…From April 2022, as part of the UK government’s new obesity strategy, it is now compulsory for all larger restaurant and cafes in the UK to include calorie…”
Get full text

GDF15 mediates the effects of metformin on body weight and energy balance by Coll, Anthony P., Chen, Michael, Taskar, Pranali, Rimmington, Debra, Patel, Satish, Tadross, John A., Cimino, Irene, Yang, Ming, Welsh, Paul, Virtue, Samuel, Goldspink, Deborah A., Miedzybrodzka, Emily L., Konopka, Adam R., Esponda, Raul Ruiz, Huang, Jeffrey T.-J., Tung, Y. C. Loraine, Rodriguez-Cuenca, Sergio, Tomaz, Rute A., Harding, Heather P., Melvin, Audrey, Yeo, Giles S. H., Preiss, David, Vidal-Puig, Antonio, Vallier, Ludovic, Nair, K. Sreekumaran, Wareham, Nicholas J., Ron, David, Gribble, Fiona M., Reimann, Frank, Sattar, Naveed, Savage, David B., Allan, Bernard B., O’Rahilly, Stephen

“…Metformin, the world’s most prescribed anti-diabetic drug, is also effective in preventing type 2 diabetes in people at high risk 1 , 2 . More than 60% of this…”
Get full text

Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney by Festa, Beatrice Paola, Chen, Zhiyong, Berquez, Marine, Debaix, Huguette, Tokonami, Natsuko, Prange, Jenny Ann, Hoek, Glenn van de, Alessio, Cremonesi, Raimondi, Andrea, Nevo, Nathalie, Giles, Rachel H., Devuyst, Olivier, Luciani, Alessandro

“…The endolysosomal system sustains the reabsorptive activity of specialized epithelial cells. Lysosomal storage diseases such as nephropathic cystinosis cause a…”
Get full text

Tree ring dating using oxygen isotopes: a master chronology for central England by Loader, Neil J., Mccarroll, Danny, Miles, Daniel, Young, Giles H. F., Davies, Darren, Ramsey, Christopher Bronk

“…ABSTRACT Ring‐width dendrochronology, based on matching patterns of ring width variability, works best when trees are growing under significant environmental…”
Get full text

Changes in atmospheric circulation and the Arctic Oscillation preserved within a millennial length reconstruction of summer cloud cover from northern Fennoscandia by Young, Giles H. F., McCarroll, Danny, Loader, Neil J., Gagen, Mary H., Kirchhefer, Andreas J., Demmler, Joanne C.

“…Cloud cover currently represents the single greatest source of uncertainty in General Circulation Models. Stable carbon isotope ratios (δ 13 C) from…”
Get full text

Updated European Association of Urology Guidelines: Recommendations for the Treatment of First-line Metastatic Clear Cell Renal Cancer by Powles, Thomas, Albiges, Laurence, Staehler, Michael, Bensalah, Karim, Dabestani, Saeed, Giles, Rachel H., Hofmann, Fabian, Hora, Milan, Kuczyk, Markus A., Lam, Thomas B., Marconi, Lorenzo, Merseburger, Axel S., Fernández-Pello, Sergio, Tahbaz, Rana, Volpe, Alessandro, Ljungberg, Börje, Bex, Axel

“…The randomised phase III clinical trial Checkmate-214 showed a survival superiority for the combination of ipilimumab and nivolumab when compared with the…”
Get full text

Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry by Habib, Abdella M, Richards, Paul, Cairns, Lynne S, Rogers, Gareth J, Bannon, Christopher A. M, Parker, Helen E, Morley, Tom C. E, Yeo, Giles S. H, Reimann, Frank, Gribble, Fiona M

“…The intestine secretes a range of hormones with important local and distant actions, including the control of insulin secretion and appetite. A number of…”
Get full text

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse by McMurray, Fiona, Church, Chris D, Larder, Rachel, Nicholson, George, Wells, Sara, Teboul, Lydia, Tung, Y C Loraine, Rimmington, Debra, Bosch, Fatima, Jimenez, Veronica, Yeo, Giles S H, O'Rahilly, Stephen, Ashcroft, Frances M, Coll, Anthony P, Cox, Roger D

“…The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The…”
Get full text

Trends in outpatient visits for insomnia, sleep apnea, and prescriptions for sleep medications among US adults: findings from the National Ambulatory Medical Care survey 1999-2010 by Ford, Earl S, Wheaton, Anne G, Cunningham, Timothy J, Giles, Wayne H, Chapman, Daniel P, Croft, Janet B

“…To examine recent national trends in outpatient visits for sleep related difficulties in the United States and prescriptions for sleep medications. Trend…”
Get full text