Search Results - "Giles, H D"

Biotransformation potential of phytosterols under anoxic and anaerobic conditions by DYKSTRA, C. M, GILES, H. D, BANERJEE, S, PAVLOSTATHIS, S. G

“…The biotransformation potential of three phytosterols (campesterol, stigmasterol and β-sitosterol) under denitrifying, sulfate-reducing and…”
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Toxicity of Lactide in Dogs after 2 and 13 Weeks of Daily Oral Dosing by Hébert, C.D, Giles, H.D, Heath, J.E, Hogan, D.B, Modderman, J.P, Conn, R.E

“…Two-week and 13-week studies were conducted to determine the toxicity of lactide when the compound is administered orally in gelatin capsules to beagle dogs…”
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Furan-induced hepatic cholangiocarcinomas in Fischer 344 rats by Maronpot, R R, Giles, H D, Dykes, D J, Irwin, R D

“…In a 2-yr carcinogenicity bioassay, 0, 2, 4, or 8 mg furan/kg body weight (BW) was administered to male and female Fischer (F344) rats and resulted in an…”
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Carcinogenicity of 2',3'-dideoxycytidine in mice by RAO, G. N, COLLINS, B. J, GILES, H. D, HEATH, J. E, FOLEY, J. F, MAY, R. D, BUCKLEY, L. A

“…2',3'-dideoxycytidine (ddC) is a synthetic pyrimidine nucleoside analogue approved for treatment of HIV-positive patients. Previous studies indicated that ddC…”
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Subchronic Toxicity of Human Immunodeficiency Virus and Tuberculosis Combination Therapies in B6C3F1 Mice by Rao, Ghanta N., Lindamood, Charles, Heath, James E., Farnell, Daniel R., Giles, Herschell D.

“…Combination therapy with anti-HIV drugs and opportunistic infection drugs is a common practice in treatment of AIDS patients. Although toxic effects of most…”
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Chordomas in Fischer 344 rats by Stefanski, S A, Elwell, M R, Mitsumori, K, Yoshitomi, K, Dittrich, K, Giles, H D

“…Tissue sections and records of 56 rats with chordoma, identified in the National Toxicology Program's (NTP) data base of approximately 115,000 rats, were…”
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Encephalopathy in rats and nephropathy in rats and mice after subchronic oral exposure to benzaldehyde by Kluwe, W M, Montgomery, C A, Giles, H D, Prejean, J D

“…Male and female Fischer 344 rats and B6C3F1 mice were treated daily (5 days/wk) with benzaldehyde by gavage either in 12 doses of 0 (vehicle control), 100…”
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Hematologic toxicity of AZT and ddC administered as single agents and in combination to rats and mice by Thompson, M B, Dunnick, J K, Sutphin, M E, Giles, H D, Irwin, R D, Prejean, J D

“…Toxicity studies of 3'-azido-2',3'-dideoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC) were conducted in F344/N rats and B6C3F1 mice. The drugs were…”
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Hematologic and histopathologic evaluation of N-(phosphonacetyl)-L-aspartate (PALA) in mice by Harrison, Jr, S D, Giles, H D, Denine, E P

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Preliminary toxicity profile of arotinoids SMR-2 and SMR-6 in male B6D2F1 mice by Lindamood, 3rd, C, Giles, H D, Hill, D L

“…Arotinoids, which are analogs of retinoic acid (RA) and retinol (RO) with the carbon skeleton in a rigid conformation, have more favorable therapeutic indices…”
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Pharmacological and toxicological properties of arotinoids SMR-2 and SMR-6 in mice by Lindamood, 3rd, C, Cope, F O, Dillehay, D L, Everson, M P, Giles, H D, Lamon, E W, McCarthy, D J, Sartin, J L, Hill, D L

“…Studies were conducted to define primary pharmacological and toxicological properties of two arotinoids, SMR-2 and SMR-6, in male B6D2F1 mice. Mice were…”
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Evidence for toxicologic activity of ftorafur independent of conversion to 5-fluorouracil by Harrison, Jr, S D, Denine, E P, Giles, H D

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Toxicologic and immunologic evaluations of N-(all-trans-retinoyl)-DL-leucine and N-(all-trans-retinoyl)glycine by Lindamood, 3rd, C, Dillehay, D L, Lamon, E W, Giles, H D, Shealy, Y F, Sani, B P, Hill, D L

“…Sprague-Dawley rats were dosed by gavage daily for 28 days with 5, 15, or 50 mg/kg of N-(all-trans-retinoyl)-DL-leucine (RL), N-(all-trans-retinoyl)glycine…”
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Modification of retinyl acetate toxicity in rats by coadministration of menhaden oil by Lindamood, 3rd, C, Mac Thigpen, L, Giles, H D, Makovec, G T, McCarthy, D J, Hill, D L

“…Menhaden oil, which has hypolipidemic and anticarcinogenic activity, reduces the hypertriglyceridemia caused by retinyl acetate. Male Sprague-Dawley rats were…”
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Antitumor drug toxicity in tumor-free and tumor-bearing mice by Harrison, Jr, S D, Giles, H D, Denine, E P

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Complete heart block associated with vegetative endocarditis in a dog by Robertson, B T, Giles, H D

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Total and State-Specific Medical and Absenteeism Costs of COPD Among Adults Aged 18 Years in the United States for 2010 and Projections Through 2020 by Ford, Earl S., MD, MPH, Murphy, Louise B., PhD, Khavjou, Olga, MA, Giles, Wayne H., MD, Holt, James B., PhD, Croft, Janet B., PhD

“…BACKGROUND COPD remains a leading cause of morbidity and mortality. The objectives of this study were to estimate (1) national US COPD-attributable annual…”
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COPD Surveillance—United States, 1999-2011 by Ford, Earl S., MD, MPH, Croft, Janet B., PhD, Mannino, David M., MD, FCCP, Wheaton, Anne G., PhD, Zhang, Xingyou, PhD, Giles, Wayne H., MD

“…This report updates surveillance results for COPD in the United States. For 1999 to 2011, data from national data systems for adults aged ≥ 25 years were…”
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Subchronic toxicity studies of t-butyl alcohol in rats and mice by Lindamood, 3rd, C, Farnell, D R, Giles, H D, Prejean, J D, Collins, J J, Takahashi, K, Maronpot, R R

“…The purpose of this study was to evaluate the toxicity of t-butyl alcohol, an important commodity chemical, an additive to unleaded gasoline, and a contaminant…”
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Adverse Childhood Experiences and Chronic Obstructive Pulmonary Disease in Adults by Anda, Robert F., MD, MS, Brown, David W., MSPH, MS, Dube, Shanta R., PhD, MPH, Bremner, J. Douglas, MD, Felitti, Vincent J., MD, Giles, Wayne H., MD, MS

“…Background Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality in the U.S. However, little is known about the…”
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