Search Results - "Gilden, Julia K."

The septin cytoskeleton facilitates membrane retraction during motility and blebbing by Gilden, Julia K, Peck, Sebastian, Chen, Yi-Chun M, Krummel, Matthew F

“…Increasing evidence supports a critical role for the septin cytoskeleton at the plasma membrane during physiological processes including motility, formation of…”
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A septin requirement differentiates autonomous and contact-facilitated T cell proliferation by Mujal, Adriana M, Gilden, Julia K, Gérard, Audrey, Kinoshita, Makoto, Krummel, Matthew F

“…T cells proliferate in response to cues provided by antigen-presenting cells or high concentrations of cytokines. Krummel and colleagues reveal a distinct…”
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Simple, Rapid Chemical Labeling and Screening of Antibodies with Luminescent Peptides by Kincaid, Virginia A., Wang, Hui, Sondgeroth, Casey A., Torio, Emily A., Ressler, Valerie T., Fitzgerald, Connor, Hall, Mary P., Hurst, Robin, Wood, Monika G., Gilden, Julia K., Kirkland, Thomas A., Lazar, Dan, Chia-Chang, Hsu, Encell, Lance P., Machleidt, Thomas, Zhou, Wenhui, Dart, Melanie L.

“…Sensitive and selective detection assays are essential for the accurate measurement of analytes in both clinical and research laboratories. Immunoassays that…”
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978 Stage-appropriate bioassays for assessing ADCP activity of therapeutic antibodies by Gilden, Julia K, Mitchell, Jonathan, Stecha, Pete, Hartnett, Jim, Grailer, Jamison, Fan, Frank, Cong, Mei

“…BackgroundAntibody-dependent Cellular Phagocytosis (ADCP) is an important mechanism of action (MOA) of therapeutic antibodies designed to deplete tumor cells…”
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The role of the PI(3,5)P 2 kinase TbFab1 in endo/lysosomal trafficking in Trypanosoma brucei by Gilden, Julia K, Umaer, Khan, Kruzel, Emilia K, Hecht, Oliver, Correa, Renan O, Mansfield, John M, Bangs, James D

“…Protein trafficking through endo/lysosomal compartments is critically important to the biology of the protozoan parasite Trypanosoma brucei, but the routes…”
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The role of the PI(3,5)P2 kinase TbFab1 in endo/lysosomal trafficking in Trypanosoma brucei by Gilden, Julia K., Umaer, Khan, Kruzel, Emilia K., Hecht, Oliver, Correa, Renan O., Mansfield, John M., Bangs, James D.

“…[Display omitted] •TbFab1 synthesizes the phosphoinositide PI(3,5)P2 in Trypanosoma brucei.•TbFab1 and PI(3,5)P2 localize to the late endosome and…”
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Brugia malayi Microfilariae Induce Cell Death in Human Dendritic Cells, Inhibit Their Ability to Make IL-12 and IL-10, and Reduce Their Capacity to Activate CD4+ T Cells by Semnani, Roshanak Tolouei, Liu, Anne Y, Sabzevari, Helen, Kubofcik, Joseph, Zhou, Jun, Gilden, Julia K, Nutman, Thomas B

“…Parasite Ag-specific T cell unresponsiveness and diminished IFN-gamma production are immunologic hallmarks of patent infection with lymph-dwelling filarial…”
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Normal Development and Activation but Altered Cytokine Production of Fyn-Deficient CD4+ T Cells by Mamchak, Alusha A, Sullivan, Brandon M, Hou, Baidong, Lee, Linda M, Gilden, Julia K, Krummel, Matthew F, Locksley, Richard M, DeFranco, Anthony L

“…The Src family kinase Fyn is expressed in T cells and has been shown to phosphorylate proteins involved in TCR signaling, cytoskeletal reorganization, and IL-4…”
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Abstract 2179: Novel bioluminescent bioassays for the discovery and development of molecular and cellular T cell redirecting cancer therapy by Gilden, Julia K., Grailer, Jamison, Slater, Michael, Stecha, Pete, Hartnett, Jim, Lazar, Dan, Fan, Frank, Cong, Mei, Cheng, Zhijie Jey

“…Abstract Redirected T cell therapies represent a new paradigm for cancer treatment. Two main approaches for T-cell-based therapies involve molecular T cell…”
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Abstract 5595: Rapid and sensitive determination of cytokine release from cells without the need for sample transfer by Lazar, Dan F., Kupcho, Kevin R., Sondgeroth, Casey A., Thompson, David V., O'Brien, Martha A., Gilden, Julia K., Hsiao, Kevin, Cali, James J.

“…Abstract Cytokines play a major role in cancer biology as inflammatory and immunomodulatory agents and are frequently measured in cell culture models and other…”
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Rapid and sensitive determination of cytokine release from cells without the need for sample transfer by Lazar, Dan F, Kupcho, Kevin R, Sondgeroth, Casey A, Hsiao, Kevin, Thompson, David V, O’Brien, Martha A, Gilden, Julia K, Cali, James J

“…Abstract We have utilized NanoLuc® Binary Technology (NanoBiT®) to develop a homogeneous and rapid assay method (≤ 70 min completion time) to measure cytokines…”
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Abstract 5672: Quantitative cell-based assays for characterization of antibodies targeting co-stimulatory immune checkpoint receptors by Gilden, Julia K., Wang, Jun, Beck, Michael, Grailer, Jamison, Hartnett, Jim, Fan, Frank, Cong, Mei, Cheng, Zhe-jie Jey

“…Abstract The human immune system is regulated by a broad network of co-inhibitory and co-stimulatory receptors that control the type, scale, and duration of…”
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Abstract 3202: NanoBiT technologies for CAR-T characterization and potency testing by Gilden, Julia K., Stecha, Pete, Paguio, Aileen, Hartnett, Jim, Binkowski, Brock, Lazar, Dan, Fan, Frank, Cong, Mei

“…Abstract Despite significant clinical advances in CAR-T cell therapies for cancer, the ability to precisely and reproducibly analyze the potency of these drug…”
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The role of the Septin cytoskeleton in primary T cell migration (95.3) by Gilden, Julia K, Krummel, Matthew F

“…Abstract The highly-conserved Septin family of GTP-binding proteins form filamentous networks in many cell types and have been implicated in a variety…”
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