Search Results - "Gilchrist, Robert B"

The epidermal growth factor network: role in oocyte growth, maturation and developmental competence by Richani, Dulama, Gilchrist, Robert B

“…The LH surge induces great physiological changes within the preovulatory follicle, which culminate in the ovulation of a mature oocyte that is capable of…”
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Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence by Richani, Dulama, Dunning, Kylie R, Thompson, Jeremy G, Gilchrist, Robert B

“…Abstract BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its surrounding somatic cells. Metabolism plays a critical role…”
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Approaches to oocyte meiotic arrest in vitro and impact on oocyte developmental competence by Richani, Dulama, Gilchrist, Robert B

“…Oocytes are maintained in a state of meiotic arrest following the first meiotic division until ovulation is triggered. Within the antral follicle, meiotic…”
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Bidirectional communication between cumulus cells and the oocyte: Old hands and new players? by Russell, Darryl L., Gilchrist, Robert B., Brown, Hannah M., Thompson, Jeremy G.

“…Cumulus cell–oocyte communication is an essential feature of mammalian reproduction. Established mechanisms involve the bidirectional transfer of ions and…”
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Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome by Caldwell, Aimee S. L., Edwards, Melissa C., Desai, Reena, Jimenez, Mark, Gilchrist, Robert B., Handelsman, David J., Walters, Kirsty A.

“…Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS…”
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Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality by Gilchrist, Robert B., Lane, Michelle, Thompson, Jeremy G.

“…Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of what constitutes oocyte quality or the mechanisms governing…”
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Perspectives on the development and future of oocyte IVM in clinical practice by De Vos, Michel, Grynberg, Michaël, Ho, Tuong M., Yuan, Ye, Albertini, David F., Gilchrist, Robert B.

“…Oocyte in vitro maturation (IVM) is an assisted reproductive technology designed to obtain mature oocytes following culture of immature cumulus–oocyte…”
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The definition of IVM is clear—variations need defining by De Vos, Michel, Smitz, Johan, Thompson, Jeremy G., Gilchrist, Robert B.

“…Abstract Oocyte in vitro maturation (IVM) is currently defined as the maturation in vitro of immature cumulus–oocyte complexes collected from antral follicles…”
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The pivotal role of glucose metabolism in determining oocyte developmental competence by Sutton-McDowall, Melanie L, Gilchrist, Robert B, Thompson, Jeremy G

“…The environment that the cumulus oocyte complex (COC) is exposed to during either in vivo or in vitro maturation (IVM) can have profound effects on the success…”
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Defining the impact of dietary macronutrient balance on PCOS traits by Rodriguez Paris, Valentina, Solon-Biet, Samantha M., Senior, Alistair M., Edwards, Melissa C., Desai, Reena, Tedla, Nicodemus, Cox, Madeleine J., Ledger, William L., Gilchrist, Robert B., Simpson, Stephen J., Handelsman, David J., Walters, Kirsty A.

“…Lifestyle, mainly dietary, interventions are first-line treatment for women with polycystic ovary syndrome (PCOS), but the optimal diet remains undefined. We…”
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Oocyte-secreted factors enhance oocyte developmental competence by Hussein, Tamer S., Thompson, Jeremy G., Gilchrist, Robert B.

“…The capacity of fully grown oocytes to regulate their own microenvironment by paracrine factors secreted by the oocyte (oocyte-secreted factors, OSFs) may in…”
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Androgen signaling pathways driving reproductive and metabolic phenotypes in a PCOS mouse model by Aflatounian, Ali, Edwards, Melissa C, Rodriguez Paris, Valentina, Bertoldo, Michael J, Desai, Reena, Gilchrist, Robert B, Ledger, William L, Handelsman, David J, Walters, Kirsty A

“…As the mechanistic basis of polycystic ovary syndrome (PCOS) remains unknown, current management relies on symptomatic treatment. Hyperandrogenism is a major…”
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Biphasic in vitro maturation (CAPA-IVM) specifically improves the developmental capacity of oocytes from small antral follicles by Sanchez, Flor, Le, Anh H., Ho, Vu N. A., Romero, Sergio, Van Ranst, Heidi, De Vos, Michel, Gilchrist, Robert B., Ho, Tuong M., Vuong, Lan N., Smitz, Johan

“…Purpose To investigate the effectiveness of a biphasic IVM culture strategy at improving IVM outcomes in oocytes from small follicles (< 6 mm) compared with…”
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Oocyte maturation: Emerging concepts and technologies to improve developmental potential in vitro by Gilchrist, Robert B., Thompson, Jeremy G.

“…Oocyte in vitro maturation (IVM) is an important reproductive technology that generates mature oocytes that are capable of supporting preimplantation embryo…”
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Neurokinin 3 Receptor Antagonism Ameliorates Key Metabolic Features in a Hyperandrogenic PCOS Mouse Model by Sucquart, Irene E, Nagarkar, Ruchi, Edwards, Melissa C, Rodriguez Paris, Valentina, Aflatounian, Ali, Bertoldo, Michael J, Campbell, Rebecca E, Gilchrist, Robert B, Begg, Denovan P, Handelsman, David J, Padmanabhan, Vasantha, Anderson, Richard A, Walters, Kirsty A

“…Polycystic ovary syndrome (PCOS) is a prevalent endocrine condition characterized by a range of endocrine, reproductive, and metabolic abnormalities. At…”
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Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes by Sugimura, Satoshi, Ritter, Lesley J., Rose, Ryan D., Thompson, Jeremy G., Smitz, Johan, Mottershead, David G., Gilchrist, Robert B.

“…Oocytes acquire developmental competence with progressive folliculogenesis. Cumulus oocyte complexes (COCs) from small antral follicles have inherent low…”
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Effect of pre-in vitro maturation with cAMP modulators on the acquisition of oocyte developmental competence in cattle by SUGIMURA, Satoshi, YAMANOUCHI, Tadayuki, PALMERINI, Maria Grazia, HASHIYADA, Yutaka, IMAI, Kei, GILCHRIST, Robert B

“…The administration of follicle-stimulating hormone (FSH) prior to oocyte retrieval improves oocyte developmental competence. During bovine embryo production in…”
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In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies by Bertoldo, Michael J., Walters, Kirsty A., Ledger, William L., Gilchrist, Robert B., Mermillod, Pascal, Locatelli, Yann

“…Ovarian tissue is increasingly being collected from cancer patients and cryopreserved for fertility preservation. While the only available option to restore…”
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Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence by Sudiman, Jaqueline, Sutton-McDowall, Melanie L, Ritter, Lesley J, White, Melissa A, Mottershead, David G, Thompson, Jeremy G, Gilchrist, Robert B

“…Developmental competence of in vitro matured (IVM) oocytes needs to be improved and this can potentially be achieved by adding recombinant bone morphogenetic…”
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The interplay between PCOS pathology and diet on gut microbiota in a mouse model by Rodriguez Paris, Valentina, Wong, Xin Yi Denise, Solon-Biet, Samantha M, Edwards, Melissa C, Aflatounian, Ali, Gilchrist, Robert B, Simpson, Stephen J, Handelsman, David J, Kaakoush, Nadeem O, Walters, Kirsty A

“…The gut microbiome has been implicated in polycystic ovary syndrome (PCOS) pathophysiology. PCOS is a disorder with reproductive, endocrine and metabolic…”
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