Search Results - "Gilbert, Robert J. C"

pH dependence of listeriolysin O aggregation and pore‐forming ability by Bavdek, Andrej, Kostanjšek, Rok, Antonini, Valeria, Lakey, Jeremy H., Dalla Serra, Mauro, Gilbert, Robert J. C., Anderluh, Gregor

“…Listeriolysin O (LLO) is the major factor implicated in the escape of Listeria monocytogenes from the phagolysosome. It is the only representative of…”
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Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins by Peyret, Hadrien, Gehin, Annick, Thuenemann, Eva C, Blond, Donatienne, El Turabi, Aadil, Beales, Lucy, Clarke, Dean, Gilbert, Robert J C, Fry, Elizabeth E, Stuart, David I, Holmes, Kris, Stonehouse, Nicola J, Whelan, Mike, Rosenberg, William, Lomonossoff, George P, Rowlands, David J

“…The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when expressed in a variety of heterologous…”
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Effects of MACPF/CDC proteins on lipid membranes by Gilbert, Robert J. C., Mikelj, Miha, Dalla Serra, Mauro, Froelich, Christopher J., Anderluh, Gregor

“…Recent work on the MACPF/CDC superfamily of pore-forming proteins has focused on the structural analysis of monomers and pore-forming oligomeric complexes. We…”
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A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting by Namy, Olivier, Gilbert, Robert J. C, Moran, Stephen J, Stuart, David I, Brierley, Ian

“…The triplet-based genetic code requires that translating ribosomes maintain the reading frame of a messenger RNA faithfully to ensure correct protein…”
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Incomplete pneumolysin oligomers form membrane pores by Sonnen, Andreas F.-P., Plitzko, Jürgen M., Gilbert, Robert J. C.

“…Pneumolysin is a member of the cholesterol-dependent cytolysin (CDC) family of pore-forming proteins that are produced as water-soluble monomers or dimers,…”
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Perforin rapidly induces plasma membrane phospholipid flip-flop by Metkar, Sunil S, Wang, Baikun, Catalan, Elena, Anderluh, Gregor, Gilbert, Robert J C, Pardo, Julian, Froelich, Christopher J

“…The cytotoxic cell granule secretory pathway is essential for host defense. This pathway is fundamentally a form of intracellular protein delivery where…”
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Molecular Determinants of Sphingomyelin Specificity of a Eukaryotic Pore-forming Toxin by Bakrač, Biserka, Gutiérrez-Aguirre, Ion, Podlesek, Zdravko, Sonnen, Andreas F.-P., Gilbert, Robert J.C., Maček, Peter, Lakey, Jeremy H., Anderluh, Gregor

“…Sphingomyelin (SM) is abundant in the outer leaflet of the cell plasma membrane, with the ability to concentrate in so-called lipid rafts. These specialized…”
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Perforin activity at membranes leads to invaginations and vesicle formation by Praper, Tilen, Sonnen, Andreas F.-P, Kladnik, Aleš, Andrighetti, Alberto O, Viero, Gabriella, Morris, Keith J, Volpi, Emanuela, Lunelli, Lorenzo, Serra, Mauro Dalla, Froelich, Christopher J, Gilbert, Robert J. C, Anderluh, Gregor

“…The cytotoxic cell granule secretory pathway is essential for immune defence. How the pore-forming protein perforin (PFN) facilitates the cytosolic delivery of…”
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The Platelet Receptor CLEC-2 Is Active as a Dimer by Watson, Aleksandra A, Christou, Charita M, James, John R, Fenton-May, Angharad E, Moncayo, Gerald E, Mistry, Anita R, Davis, Simon J, Gilbert, Robert J. C, Chakera, Aron, O’Callaghan, Chris A

“…The platelet receptor CLEC-2 binds to the snake venom toxin rhodocytin and the tumor cell surface protein podoplanin. Binding of either of these ligands…”
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Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs by Yi, Gangshun, Ye, Mingda, Carrique, Loic, El-Sagheer, Afaf, Brown, Tom, Norbury, Chris J., Zhang, Peijun, Gilbert, Robert J. C.

“…Tumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either promote let-7 maturation by adding a…”
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Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin by Zebisch, Matthias, Xu, Yang, Krastev, Christos, MacDonald, Bryan T., Chen, Maorong, Gilbert, Robert J. C., He, Xi, Jones, E. Yvonne

“…The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult stem cell biology. Through…”
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Viral RNA pseudoknots: versatile motifs in gene expression and replication by Brierley, Ian, Pennell, Simon, Gilbert, Robert J. C

“…RNA pseudoknots are structural elements found in almost all classes of RNA. First recognized in the genomes of plant viruses, they are now established as a…”
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Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates? by Gaskell, Louise J, Osman, Fekret, Gilbert, Robert JC, Whitby, Matthew C

“…The Holliday junction (HJ) is a central intermediate of homologous recombination. Its cleavage is critical for the formation of crossover recombinants during…”
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Structural insights into proteoglycan-shaped Hedgehog signaling by Whalen, Daniel M., Malinauskas, Tomas, Gilbert, Robert J. C., Siebold, Christian

“…Hedgehog (Hh) morphogens play fundamental roles during embryogenesis and adulthood, in health and disease. Multiple cell surface receptors regulate the Hh…”
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Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling by Griffiths, Samuel C., Schwab, Rebekka A., El Omari, Kamel, Bishop, Benjamin, Iverson, Ellen J., Malinauskas, Tomas, Dubey, Ramin, Qian, Mingxing, Covey, Douglas F., Gilbert, Robert J. C., Rohatgi, Rajat, Siebold, Christian

“…Hedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to…”
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Editorial: Perforins and Cholesterol-Dependent Cytolysins in Immunity and Pathogenesis by Munson, George P., Gilbert, Robert J. C., Pradel, Gabriele

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Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly by Podobnik, Marjetka, Savory, Peter, Rojko, Nejc, Kisovec, Matic, Wood, Neil, Hambley, Richard, Pugh, Jonathan, Wallace, E. Jayne, McNeill, Luke, Bruce, Mark, Liko, Idlir, Allison, Timothy M., Mehmood, Shahid, Yilmaz, Neval, Kobayashi, Toshihide, Gilbert, Robert J. C., Robinson, Carol V., Jayasinghe, Lakmal, Anderluh, Gregor

“…The invertebrate cytolysin lysenin is a member of the aerolysin family of pore-forming toxins that includes many representatives from pathogenic bacteria. Here…”
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Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity by Wang, Lihui, Gilbert, Robert J.C, Atilano, Magda L, Filipe, Sergio R, Gay, Nicholas J, Ligoxygakis, Petros

“…In Drosophila, the enzymatic activity of the glucan binding protein GNBP1 is needed to present Gram-positive peptidoglycan (PG) to peptidoglycan recognition…”
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Hepatitis B Small Surface Antigen Particles Are Octahedral by Robert J. C. Gilbert, Lucy Beales, Donatienne Blond, Simon, Martha N., Beth Y. Lin, Chisari, Francis V., Stuart, David I., Rowlands, David J.

“…The infectious component of hepatitis B (HB) virus (HBV), the Dane particle, has a diameter of ≈44 nm and consists of a double-layered capsid particle…”
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Structural Basis for Plexin Activation and Regulation by Kong, Youxin, Janssen, Bert J.C., Malinauskas, Tomas, Vangoor, Vamshidhar R., Coles, Charlotte H., Kaufmann, Rainer, Ni, Tao, Gilbert, Robert J.C., Padilla-Parra, Sergi, Pasterkamp, R. Jeroen, Jones, E. Yvonne

“…Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nervous system development and plasticity, ranging from axon guidance and…”
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