Search Results - "Gilbert, M.E."

Developmental thyroid hormone insufficiency and brain development: A role for brain-derived neurotrophic factor (BDNF)? by Gilbert, M.E, Lasley, S.M

“…Highlights ► Thyroid hormone is essential for brain development. ► Neurotrophins, including BDNF, regulate a number of developmental processes. ► The role of…”
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Adult hippocampal neurogenesis is impaired by transient and moderate developmental thyroid hormone disruption by Gilbert, M.E., Goodman, J.H., Gomez, J., Johnstone, A.F.M., Ramos, R.L.

“…•Neurogenesis occurs in adult hippocampus and plays a role in learning and memory.•The hippocampus is sensitive to developmental thyroid hormone…”
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New and evolving concepts in the neurotoxicology of lead by White, L.D., Cory-Slechta, D.A., Gilbert, M.E., Tiffany-Castiglioni, E., Zawia, N.H., Virgolini, M., Rossi-George, A., Lasley, S.M., Qian, Y.C., Basha, Md. Riyaz

“…Lead (Pb) is a xenobiotic metal with no known essential function in cellular growth, proliferation, or signaling. Decades of research characterizing the…”
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Dose-dependent reductions in spatial learning and synaptic function in the dentate gyrus of adult rats following developmental thyroid hormone insufficiency by Gilbert, M.E., Sui, Li

“…Thyroid hormones are critical for the development and maturation of the central nervous system. Although somatic and neurological effects are well documented…”
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Field confirmation of genetic variation in soybean transpiration response to vapor pressure deficit and photosynthetic compensation by Gilbert, M.E., Holbrook, N.M., Zwieniecki, M.A., Sadok, W., Sinclair, T.R.

“…• Previous greenhouse study documented genetic differences in expression of a maximum transpiration rate. • This field study confirmed the same genetic…”
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Thyroid hormone-dependent formation of a subcortical band heterotopia (SBH) in the neonatal brain is not exacerbated under conditions of low dietary iron (FeD) by Spring, S.R, Bastian, T.W, Wang, Y, Kosian, P, Anderson, G.W, Gilbert, M.E

“…Abstract Thyroid hormones (TH) are critical for brain development and insufficiencies can lead to structural abnormalities in specific brain regions…”
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Selective cognitive deficits in adult rats after prenatal exposure to inhaled ethanol by Oshiro, W.M, Beasley, T.E, McDaniel, K.L, Taylor, M.M, Evansky, P, Moser, V.C, Gilbert, M.E, Bushnell, P.J

“…Abstract Increased use of ethanol blends in gasoline suggests a need to assess the potential public health risks of exposure to these fuels. Ethanol consumed…”
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Developmental thyroid hormone insufficiency reduces expression of brain-derived neurotrophic factor (BDNF) in adults but not in neonates by Lasley, S.M, Gilbert, M.E

“…Abstract Brain-derived neurotrophic factor (BDNF) is a neurotrophin critical for many developmental and physiological aspects of CNS function. Severe…”
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Developmental lead (Pb) exposure reduces the ability of the NMDA antagonist MK-801 to suppress long-term potentiation (LTP) in the rat dentate gyrus, in vivo by Gilbert, M.E, Lasley, S.M

“…Abstract Chronic developmental lead (Pb) exposure increases the threshold and enhances decay of long-term potentiation (LTP) in the dentate gyrus of the…”
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Marginal iodide deficiency and thyroid function: Dose–response analysis for quantitative pharmacokinetic modeling by Gilbert, M.E, McLanahan, E.D, Hedge, J, Crofton, K.M, Fisher, J.W, Valentín-Blasini, L, Blount, B.C

“…Abstract Severe iodine deficiency (ID) results in adverse health outcomes and remains a benchmark for understanding the effects of developmental…”
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Prenatal exposure to vapors of gasoline–ethanol blends causes few cognitive deficits in adult rats by Oshiro, W.M, Beasley, T.E, McDaniel, K.L, Evansky, P.A, Martin, S.A, Moser, V.C, Gilbert, M.E, Bushnell, P.J

“…Abstract Developmental exposure to inhaled ethanol–gasoline fuel blends is a potential public health concern. Here we assessed cognitive functions in adult…”
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Reproductive effects of maternal and pre-weaning undernutrition in rat offspring: Age at puberty, onset of female reproductive senescence and intergenerational pup growth and viability by Chernoff, N., Gage, M.I., Stoker, T.E., Cooper, R.L., Gilbert, M.E., Rogers, E.H.

“…Maternal and/or postnatal undernutrition are widespread in human populations and are components of many experimental developmental and reproductive toxicology…”
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Alterations in synaptic transmission and plasticity in area CA1 of adult hippocampus following developmental hypothyroidism by Gilbert, M.E.

“…Transient reductions in thyroid hormone during critical periods of brain development can have devastating and irreversible effects on neurological function…”
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Propylthiouracil (PTU)-induced hypothyroidism in the developing rat impairs synaptic transmission and plasticity in the dentate gyrus of the adult hippocampus by Gilbert, M.E, Paczkowski, C

“…Reductions in thyroid hormone during critical periods of brain development can have devastating effects on neurological function that are permanent…”
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Developmental exposure to perchlorate alters synaptic transmission in hippocampus of the adult rat in vivo by Gilbert, M.E, Sui, Li

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Moderate developmental undernutrition: Impact on growth and cognitive function in youth and old age by Gilbert, M.E, MacPhail, R, Baldwin, J, Moser, V.C, Chernoff, N

“…Abstract Low weight at birth is a common adverse developmental effect reported in human populations and animal toxicity studies. Epidemiological evidence links…”
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Prenatal thyroid hormone insufficiency produces an abnormal cell formation within the corpus callosum of the rat by Gilbert, M.E, Goodman, J.H

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Undernutrition in early life does not impair learning in young or aging animals by Baldwin, J, Chernoff, N, Gage, M, Macphail, R, Gilbert, M.E

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Field potential recordings in dentate gyrus of anesthetized rats: Stability of baseline by Gilbert, M.E., Mack, C.M.

“…Urethane is a standard anesthetic utilized for in vivo recordings in the hippocampus. In studies of long‐term potentiation (LTP), the measure of interest is…”
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The NMDA antagonist, MK-801, suppresses long-term potentiation, kindling, and kindling-induced potentiation in the perforant path of the unanesthetized rat by Gilbert, M E, Mack, C M

“…Antagonism of NMDA-mediated transmission by MK-801 has been shown to block long-term potentiation (LTP) in vitro and delay electrical kindling of the amygdala…”
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