Search Results - "Gilbert, James W."

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier by Godinho, Bruno M.D.C., Henninger, Nils, Bouley, James, Alterman, Julia F., Haraszti, Reka A., Gilbert, James W., Sapp, Ellen, Coles, Andrew H., Biscans, Annabelle, Nikan, Mehran, Echeverria, Dimas, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

“…Effective transvascular delivery of therapeutic oligonucleotides to the brain presents a major hurdle to the development of gene silencing technologies for…”
Get full text

Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs by Gilbert, James W., Kennedy, Zachary, Godinho, Bruno M.D.C., Summers, Ashley, Weiss, Alexandra, Echeverria, Dimas, Bramato, Brianna, McHugh, Nicholas, Cooper, David, Yamada, Ken, Hassler, Matthew, Tran, Hélène, Gao, Fen Biao, Brown, Robert H., Khvorova, Anastasia

“…A hexanucleotide (G4C2) repeat expansion (HRE) within intron one of C9ORF72 is the leading genetic cause of amyotrophic lateral sclerosis (ALS) and…”
Get full text

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs by Godinho, Bruno M.D.C., Knox, Emily G., Hildebrand, Samuel, Gilbert, James W., Echeverria, Dimas, Kennedy, Zachary, Haraszti, Reka A., Ferguson, Chantal M., Coles, Andrew H., Biscans, Annabelle, Caiazzi, Jillian, Alterman, Julia F., Hassler, Matthew R., Khvorova, Anastasia

“…Effective systemic delivery of small interfering RNAs (siRNAs) to tissues other than liver remains a challenge. siRNAs are small (∼15 kDa) and therefore…”
Get full text

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep by Ferguson, Chantal M, Godinho, Bruno Mdc, Alterman, Julia F, Coles, Andrew H, Hassler, Matthew, Echeverria, Dimas, Gilbert, James W, Knox, Emily G, Caiazzi, Jillian, Haraszti, Reka A, King, Robert M, Taghian, Toloo, Puri, Ajit, Moser, Richard P, Gounis, Matthew J, Aronin, Neil, Gray-Edwards, Heather, Khvorova, Anastasia

“…siRNAs comprise a class of drugs that can be programmed to silence any target gene. Chemical engineering efforts resulted in development of divalent siRNAs…”
Get full text

Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System by Kennedy, Zachary, Gilbert, James W, Godinho, Bruno M D C

“…Therapeutic oligonucleotides hold tremendous potential for treating central nervous system (CNS) disorders. The route of administration of oligonucleotides…”
Get more information

Cerebellitis in Infectious Mononucleosis by Gilbert, James W, Culebras, Antonio

“…To the Editor.—Infectious mononucleosis may be related to infection with the EB virus, and involves many organ systems. Although not common, involvement of the…”
Get full text

Some Thermodynamic Properties Of Liquid Chloroethane by Gilbert, James W, Lagemann, Robert T

Get full text

Metabolic costs and heart rate responses to treadmill walking in water at different depths and temperatures by Gleim, G W, Nicholas, J A

“…Treadmill walking/jogging in water is a potentially useful therapeutic modality. Since energy costs of this activity are unknown, we compared oxygen…”
Get more information

Subject variability of shoulder abduction strength testing by Magnusson, S P, Gleim, G W, Nicholas, J A

“…To quantify normal biological variability of shoulder abduction strength testing with an isokinetic and a hand-held dynamometer, we tested nine healthy…”
Get more information

The efficacy of manual assessment of muscle strength using a new device by Marino, M, Nicholas, J A, Gleim, G W, Rosenthal, P, Nicholas, S J

“…The purpose of this study was to compare the manual assessment of muscle strength with a small, handheld (by the examiner) force-measuring device developed by…”
Get more information

Katharine Bruce Glasier by BAILEY, BARKER, GREENWOOD, GRIFFITHS, HALL, LORD, McALLISTER, LAWRENCE, SUTHERLAND, JACK SARA ARTHUR JAMES W. MIRIAM GILBERT PETHICK MARY

Get full text

Hand and forearm strength and its relation to tennis by Strizak, A M, Gleim, G W, Sapega, A, Nicholas, J A

“…Eight expert tennis players and 12 nontennis playing controls were studied to determine the relationship between dominant and minor extremities in regard to…”
Get more information