Search Results - "Gilat, Eran"

Efficacy of antidotal treatment against sarin poisoning: The superiority of benactyzine and caramiphen by Raveh, Lily, Rabinovitz, Ishai, Gilat, Eran, Egoz, Inbal, Kapon, Joseph, Stavitsky, Ziv, Avi Weissman, Ben, Brandeis, Rachel

“…Sarin, a potent cholinesterase inhibitor, induces an array of toxic effects including convulsions and behavioral impairments. We report here on the protection…”
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Extrapolating from animal studies to the efficacy in humans of a pretreatment combination against organophosphate poisoning by LEVY, Aharon, COHEN, Giora, GILAT, Eran, KAPON, Joseph, DACHIR, Shlomit, ABRAHAM, Shlomo, HERSKOVITZ, Miriam, TEITELBAUM, Zvi, RAVEH, Lily

“…The extrapolation from animal data to therapeutic effects in humans, a basic pharmacological issue, is especially critical in studies aimed to estimate the…”
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Subcellular alterations of protein kinase C isozymes in the rat brain after organophosphate poisoning by Bloch-Shilderman, Eugenia, Kadar, Tamar, Levy, Aharon, Sahar, Rita, Rabinovitz, Ishai, Gilat, Eran

“…The protein kinase C (PKC) signaling pathway has been associated with modulation of N-metyl-D-aspartate receptor activity, motor behavior, learning, and…”
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Sarin-induced brain damage in rats is attenuated by delayed administration of midazolam by Chapman, Shira, Yaakov, Guy, Egoz, Inbal, Rabinovitz, Ishai, Raveh, Lily, Kadar, Tamar, Gilat, Eran, Grauer, Ettie

“…•Time and dose effect of midazolam was studied in rats following sarin intoxication.•Immediate treatment with TA (TMB4+atropine) displayed prolonged seizures…”
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Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction: Evidence supporting a novel target for antiarrhythmic therapy by ELOFF, Benjamin C, MS, GILAT, Eran, DSC, WAN, Xiaoping, ROSENBAUM, David S

“…Disease-induced alterations of cardiac gap junctions lead to intercellular uncoupling, which is an important mechanism of arrhythmogenesis. Therefore, drugs…”
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Using MRI for the assessment of paraoxon-induced brain damage and efficacy of antidotal treatment by Rosman, Yossi, Eisenkraft, Arik, Krivoy, Amir, Schein, Ophir, Makarovski, Igor, Shrot, Shai, Ramaty, Erez, Shilderman, Eugenia Bloch, Kapon, Joseph, Gilat, Eran, Kadar, Tamar, Maier, Stephan, Daniels, Dianne, Shneor, Ran, Salomon, Sharona, Tamar, Gregori, Last, David, Mardor, Yael

“…ABSTRACT Organophosphate intoxication induces neural toxicity as demonstrated in histological analysis of poisoned animals. Diffusion‐weighted magnetic…”
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Anticholinergic and Antiglutamatergic Agents Protect against Soman-Induced Brain Damage and Cognitive Dysfunction by Raveh, Lily, Brandeis, Rachel, Gilat, Eran, Cohen, Giora, Alkalay, David, Rabinovitz, Ishai, Sonego, Hagar, Weissman, Ben Avi

“…Soman, a powerful inhibitor of acetylcholinesterase, causes an array of toxic effects in the central nervous system including convulsions, learning and memory…”
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Subchronic exposure to low-doses of the nerve agent VX: Physiological, behavioral, histopathological and neurochemical studies by Bloch-Shilderman, Eugenia, Rabinovitz, Ishai, Egoz, Inbal, Raveh, Lily, Allon, Nahum, Grauer, Ettie, Gilat, Eran, Weissman, Ben Avi

“…The highly toxic organophosphorous compound VX [ O-ethyl- S-(isoporopylaminoethyl) methyl phosphonothiolate] undergoes an incomplete decontamination by…”
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Efficacy of the bone injection gun in the treatment of organophosphate poisoning by Eisenkraft, Arik, Gilat, Eran, Chapman, Shira, Baranes, Shlomo, Egoz, Inbal, Levy, Aharon

“…Immediate administration of antidotal treatment is crucial in severe organophosphate (OP) poisoning and the use of an open intravenous (i.v.) line might also…”
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Effect of sodium pentobarbital on the transmembrane action potential and the slow inward current of guinea pig ventricular myocytes by Gilat, E, Rubinstein, I, Binah, O

“…Barbiturates, which are widely used in clinical anesthesia, exert a negative inotropic effect on the myocardium. To investigate the mechanism for the negative…”
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Prophylaxis against Soman Inhalation Toxicity in Guinea Pigs by Pretreatment Alone with Human Serum Butyrylcholinesterase by Allon, Nahum, Raveh, Lily, Gilat, Eran, Cohen, Ephraim, Grunwald, Jacob, Ashani, Yacov

“…Human butyrylcholinesterase (HuBChE) has previously been shown to protect mice, rats, and monkeys against multiple lethal toxic doses of organophosphorus (OP)…”
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Monitoring Drug-Induced Neurodegeneration by Imaging of Peripheral Benzodiazepine Receptors by WEISSMAN, BEN AVI, BRANDEIS, RACHEL, GILAT, ERAN, COHEN, GIORA, ALKALAY, DAVID, RABINOVITZ, ISHAI, SONEGO, HAGAR, RAVEH, LILY

“…: Several drugs of abuse are known to produce an array of deleterious effects, including alterations in neuronal circuitry and, ultimately, neuronal…”
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Characterization of early plasma concentrations of midazolam in pigs after administration by an autoinjector by Levy, Aharon, Kushnir, Moshe, Chapman, Shira, Brandeis, Rachel, Teitelbaum, Zvi, Gilat, Eran

“…The treatment of organophosphate‐induced poisoning is based mainly on atropine and an oxime. Prompt anticonvulsive intervention is usually also required to…”
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Prophylaxis against Soman Inhalation Toxicity in Guinea Pigs by Pretreatment Alone with Human Serum Butyrylcholinesterase by Allon, Nahum, Raveh, Lily, Gilat, Eran, Cohen, Ephraim, Grunwald, Jacob, Ashani, Yacov

“…Human butyrylcholinesterase (HuBChE) has previously been shown to protect mice, rats, and monkeys against multiple lethal toxic doses of organophosphorus (OP)…”
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Effects of thyroid hormone on the action potential and membrane currents of guinea pig ventricular myocytes by BINAH, O, RUBINSTEIN, I, GILAT, E

“…We studied the effects of thyroid hormone on the action potential and membrane currents recorded from enzymatically dissociated guinea pig ventricular…”
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Angiotensin-Converting Enzyme Inhibition Produces Electrophysiologic But Not Antiarrhythmic Effects in the Intact Heart by Gilat, Eran, Girouard, Steven D, Pastore, Joseph M, Laurita, Kenneth R, Rosenbaum, David S

“…Although angiotensin-converting enzyme (ACE) inhibitors are known to influence favorably the structural remodeling of the heart after myocardial infarction,…”
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Single unit activity in the auditory cortex and the medial geniculate body of the rhesus monkey: behavioral modulation by Gilat, E, Perlman, I

“…Three Rhesus monkeys were trained to respond to a given auditory signal, the nature of which could be predicted from a preceding visual stimulus. The activity…”
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The inhibitory chloride channel of the lobster Panulirus penicillatus neuromuscular junction by Gilat, E, Jaslove, S W

“…1. Single channel activity was recorded from muscle membranes of the lobster Panulirus penicillatus using the patch-clamp technique. 2. Cell-attached,…”
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Triggered activity induced by K(+)-free, Na(+)-deficient solution in guinea pig ventricular muscle: the effects of ouabain, lidocaine, and Ca2+ channel blockers by Gilat, E, Aronson, R S, Nordin, C

“…Triggered activity induced by delayed afterdepolarizations has been suggested as a cellular mechanism for some arrhythmias. The development of triggered…”
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The role of reduced potassium conductance in generating triggered activity in guinea-pig ventricular muscle by Gilat, E, Nordin, C W, Aronson, R S

“…This study investigates the role of reducing potassium conductance (gK) in generating delayed afterdepolarizations and triggered activity in small preparations…”
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