Search Results - "Gilardi, Gianfranco"

Natural Compounds as Pharmaceuticals: The Key Role of Cytochromes P450 Reactivity by Di Nardo, Giovanna, Gilardi, Gianfranco

“…The design of drugs from natural products is a re-emerging area due to the need for bioactive compounds. The exploitation of natural products and their…”
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Oxygen Stability in the New [FeFe]-Hydrogenase from Clostridium beijerinckii SM10 (CbA5H) by Morra, Simone, Arizzi, Mariaconcetta, Valetti, Francesca, Gilardi, Gianfranco

“…The newly isolated Clostridium beijerinckii [FeFe]-hydrogenase CbA5H was characterized by Fourier transform infrared spectroscopy coupled to enzymatic activity…”
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A safety cap protects hydrogenase from oxygen attack by Winkler, Martin, Duan, Jifu, Rutz, Andreas, Felbek, Christina, Scholtysek, Lisa, Lampret, Oliver, Jaenecke, Jan, Apfel, Ulf-Peter, Gilardi, Gianfranco, Valetti, Francesca, Fourmond, Vincent, Hofmann, Eckhard, Léger, Christophe, Happe, Thomas

“…[FeFe]-hydrogenases are efficient H 2 -catalysts, yet upon contact with dioxygen their catalytic cofactor (H-cluster) is irreversibly inactivated. Here, we…”
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Molecular and Structural Evolution of Cytochrome P450 Aromatase by Di Nardo, Giovanna, Zhang, Chao, Marcelli, Anna Giulia, Gilardi, Gianfranco

“…Aromatase is the cytochrome P450 enzyme converting androgens into estrogen in the last phase of steroidogenesis. As estrogens are crucial in reproductive…”
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Molecular Lego of Human Cytochrome P450: The Key Role of Heme Domain Flexibility for the Activity of the Chimeric Proteins by Catucci, Gianluca, Ciaramella, Alberto, Di Nardo, Giovanna, Zhang, Chao, Castrignanò, Silvia, Gilardi, Gianfranco

“…The cytochrome P450 superfamily are heme-thiolate enzymes able to carry out monooxygenase reactions. Several studies have demonstrated the feasibility of using…”
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Breakthrough in P450 bioelectrochemistry and future perspectives by Sadeghi, Sheila J., Fantuzzi, Andrea, Gilardi, Gianfranco

“…Improving the electrochemical performance of cytochrome P450 enzymes is highly desirable due to their versatility in the recognition of different biological…”
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Optimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolites by Di Nardo, Giovanna, Gilardi, Gianfranco

“…Drug metabolism in human liver is a process involving many different enzymes. Among them, a number of cytochromes P450 isoforms catalyze the oxidation of most…”
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Heme Spin Distribution in the Substrate-Free and Inhibited Novel CYP116B5hd: A Multifrequency Hyperfine Sublevel Correlation (HYSCORE) Study by Famulari, Antonino, Correddu, Danilo, Di Nardo, Giovanna, Gilardi, Gianfranco, Mitrikas, George, Chiesa, Mario, García-Rubio, Inés

“…The cytochrome P450 family consists of ubiquitous monooxygenases with the potential to perform a wide variety of catalytic applications. Among the members of…”
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Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H by Parween, Shaheena, DiNardo, Giovanna, Baj, Francesca, Zhang, Chao, Gilardi, Gianfranco, Pandey, Amit V.

“…[Display omitted] •Mutations in POR and CYP19A1 cause disordered steroidogenesis.•POR mutations display symptoms of multiple defects in steroidogenic…”
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Posttranslational Modification of Human Cytochrome CYP4F11 by 4-Hydroxynonenal Impairs ω-Hydroxylation in Malaria Pigment Hemozoin-Fed Monocytes: The Role in Malaria Immunosuppression by Skorokhod, Oleksii, Triglione, Vincenzo, Barrera, Valentina, Di Nardo, Giovanna, Valente, Elena, Ulliers, Daniela, Schwarzer, Evelin, Gilardi, Gianfranco

“…Malaria is a frequent parasitic infection becomes life threatening due to the disequilibrated immune responses of the host. Avid phagocytosis of malarial…”
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Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine by Gao, Chongliang, Catucci, Gianluca, Castrignanò, Silvia, Gilardi, Gianfranco, Sadeghi, Sheila J.

“…Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is…”
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Editorial: Special Issue on “Flavin Monooxygenases” by Gianfranco Gilardi, Sheila J. Sadeghi

“…Flavin-containing monooxygenase are a large family of enzymes involved in an array of different reactions by activating molecular oxygen and transferring one…”
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Production of drug metabolites by human FMO3 in Escherichia coli by Catucci, Gianluca, Gilardi, Gianfranco, Sadeghi, Sheila J

“…In the course of drug discovery and development process, sufficient reference standards of drug metabolites are required, especially for preclinical/clinical…”
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The Cranberry Extract Oximacro ® Exerts in vitro Virucidal Activity Against Influenza Virus by Interfering With Hemagglutinin by Luganini, Anna, Terlizzi, Maria E, Catucci, Gianluca, Gilardi, Gianfranco, Maffei, Massimo E, Gribaudo, Giorgio

“…The defense against influenza virus (IV) infections still poses a series of challenges. The current antiviral arsenal against influenza viruses is in fact…”
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The Dark Side of the pollen: BSA-seq identified genomic regions linked to male sterility in globe artichoke by Martina, Matteo, Zayas, Aldana, Portis, Ezio, Di Nardo, Giovanna, Polli, Maria Francesca, Comino, Cinzia, Gilardi, Gianfranco, Martin, Eugenia, Acquadro, Alberto

“…Globe artichoke (Cynara cardunculus var. scolymus; 2n = 2x = 34) is a food crop consumed for its immature flower heads. Traditionally, globe artichoke varietal…”
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Binding of methimazole and NADP(H) to human FMO3: In vitro and in silico studies by Gao, Chongliang, Catucci, Gianluca, Gilardi, Gianfranco, Sadeghi, Sheila J.

“…Human flavin-containing monooxygenase isoform 3 (hFMO3) is an important hepatic drug-metabolizing enzyme, catalyzing the monooxygenation of nucleophilic…”
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Albumin/Mitotane Interaction Affects Drug Activity in Adrenocortical Carcinoma Cells: Smoke and Mirrors on Mitotane Effect with Possible Implications for Patients' Management by Schiavon, Aurora, Saba, Laura, Catucci, Gianluca, Petiti, Jessica, Puglisi, Soraya, Borin, Chiara, Reimondo, Giuseppe, Gilardi, Gianfranco, Giachino, Claudia, Terzolo, Massimo, Lo Iacono, Marco

“…Mitotane is the only drug approved for the treatment of adrenocortical carcinoma (ACC). Although it has been used for many years, its mechanism of action…”
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Catalytically self-sufficient cytochromes P450 for green production of fine chemicals by Ciaramella, Alberto, Minerdi, Daniela, Gilardi, Gianfranco

“…This review covers our current knowledge on catalytically self-sufficient cytochromes P450. These enzymes present all the advantages of the regio- and…”
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Site saturation mutagenesis demonstrates a central role for cysteine 298 as proton donor to the catalytic site in CaHydA [FeFe]-hydrogenase by Morra, Simone, Giraudo, Alberto, Di Nardo, Giovanna, King, Paul W, Gilardi, Gianfranco, Valetti, Francesca

“…[FeFe]-hydrogenases reversibly catalyse molecular hydrogen evolution by reduction of two protons. Proton supply to the catalytic site (H-cluster) is essential…”
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Activation of RSK by phosphomimetic substitution in the activation loop is prevented by structural constraints by Somale, Desiana, Di Nardo, Giovanna, di Blasio, Laura, Puliafito, Alberto, Vara-Messler, Marianela, Chiaverina, Giulia, Palmiero, Miriam, Monica, Valentina, Gilardi, Gianfranco, Primo, Luca, Gagliardi, Paolo Armando

“…The activation of the majority of AGC kinases is regulated by two phosphorylation events on two conserved serine/threonine residues located on the activation…”
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