Search Results - "Gilad, Y."

Dynamic genetic regulation of gene expression during cellular differentiation by Strober, B J, Elorbany, R, Rhodes, K, Krishnan, N, Tayeb, K, Battle, A, Gilad, Y

“…Genetic regulation of gene expression is dynamic, as transcription can change during cell differentiation and across cell types. We mapped expression…”
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DAPK2 is a novel regulator of mTORC1 activity and autophagy by Ber, Y, Shiloh, R, Gilad, Y, Degani, N, Bialik, S, Kimchi, A

“…Autophagy is a tightly regulated catabolic process, which is upregulated in cells in response to many different stress signals. Inhibition of mammalian target…”
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Synthesis, biological studies and molecular dynamics of new anticancer RGD-based peptide conjugates for targeted drug delivery by Gilad, Y., Noy, E., Senderowitz, H., Albeck, A., Firer, M.A., Gellerman, G.

“…[Display omitted] New cyclic RGD peptide-anticancer agent conjugates, with different chemical functionalities attached to the parent peptide were synthesized…”
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Dual-drug RGD conjugates provide enhanced cytotoxicity to melanoma and non-small lung cancer cells by Gilad, Y., Noy, E., Senderowitz, H., Albeck, A., Firer, M. A., Gellerman, G.

“…ABSTRACT To enhance the efficacy of targeted drug delivery, four new peptide‐ligand conjugates were synthesized, each consisting of a cyclic RGDfK…”
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Population differences in the human functional olfactory repertoire by Gilad, Yoav, Lancet, Doron

“…Olfactory receptors (OR) constitute the molecular basis for the sense of smell. They are encoded by a large multigene family that in humans includes…”
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Discovery of potent molecular chimera (CM358) to treat human metastatic melanoma by Gilad, Y., Tuchinsky, H., Ben-David, G., Minnes, R., Gancz, A., Senderowitz, H., Luboshits, G., Firer, M.A., Gellerman, G.

“…The resistance of cancer cells to chemotherapeutic agents, whether through intrinsic mechanisms or developed resistance, motivates the search for new…”
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38: Points of interface between autophagy and apoptosis by Kimchi, A, Gilad, Y, Rubinstein, A, Shilioh, R, Wigdorovitz, L

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Revealing the architecture of gene regulation: the promise of eQTL studies by Gilad, Yoav, Rifkin, Scott A, Pritchard, Jonathan K

“…Expression quantitative trait loci (eQTL) mapping studies have become a widely used tool for identifying genetic variants that affect gene regulation. In these…”
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Natural selection on gene expression by Gilad, Yoav, Oshlack, Alicia, Rifkin, Scott A.

“…Changes in genetic regulation contribute to adaptations in natural populations and influence susceptibility to human diseases. Despite their potential…”
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Characterizing natural variation using next-generation sequencing technologies by Gilad, Yoav, Pritchard, Jonathan K, Thornton, Kevin

“…Progress in evolutionary genomics is tightly coupled with the development of new technologies to collect high-throughput data. The availability of…”
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THE INTERFERENCE OF MEDICAL RADIONUCLIDES WITH OCCUPATIONAL IN VIVO GAMMA SPECTROMETRY by Kol, R, Pelled, O, Canfi, A, Gilad, Y, German, U, Laichter, Y, Lantsberg, S, Fuksbrauner, R, Gold, B

“…ABSTRACT—Radiation workers undergo routine monitoring for the evaluation of external and internal radiation exposures. The monitoring of internal exposures…”
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Initial sequence of the chimpanzee genome and comparison with the human genome by and Analysis Consortium, The Chimpanzee Sequencing

“…Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely…”
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Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates by Gilad, Yoav, Wiebe, Victor, Przeworski, Molly, Lancet, Doron, Pääbo, Svante

“…Olfactory receptor (OR) genes constitute the molecular basis for the sense of smell and are encoded by the largest gene family in mammalian genomes. Previous…”
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Synthesis of Novel Protected Nα(ω-Drug) Amino Acid Building Units for Facile Preparation of Anticancer Drug-Conjugates by Gilad, Y., Waintraub, S., Albeck, A., Gellerman, G.

“…We report about the preparation of novel protected N α (ω-drug) amino acid building units and their straightforward incorporation in solid phase synthesis for…”
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Expression profiling in primates reveals a rapid evolution of human transcription factors by Gilad, Yoav, White, Kevin P, Oshlack, Alicia, Smyth, Gordon K, Speed, Terence P

“…Although it has been hypothesized for thirty years that many human adaptations are likely to be due to changes in gene regulation, almost nothing is known…”
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Different noses for different people by Lancet, Doron, Menashe, Idan, Man, Orna, Gilad, Yoav

“…Of more than 1,000 human olfactory receptor genes, more than half seem to be pseudogenes. We investigated whether the most recent of these disruptions might…”
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Human Specific Loss of Olfactory Receptor Genes by Gilad, Yoav, Man, Orna, Pääbo, Svante, Lancet, Doron

“…Olfactory receptor (OR) genes constitute the basis for the sense of smell and are encoded by the largest mammalian gene superfamily of >1,000 genes. In humans,…”
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A comparison of the human and chimpanzee olfactory receptor gene repertoires by Gilad, Yoav, Man, Orna, Glusman, Gustavo

“…Olfactory receptor (OR) genes constitute the basis of the sense of smell and are encoded by the largest mammalian gene superfamily, with >1000 members. In…”
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Synthesis of Novel Protected N^sub [alpha]^([omega]-Drug) Amino Acid Building Units for Facile Preparation of Anticancer Drug-Conjugates by Gilad, Y, Waintraub, S, Albeck, A, Gellerman, G

“…Abstract We report about the preparation of novel protected N[alpha]([omega]-drug) amino acid building units and their straightforward incorporation in solid…”
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Prediction of the odorant binding site of olfactory receptor proteins by human–mouse comparisons by Man, Orna, Gilad, Yoav, Lancet, Doron

“…Olfactory receptors (ORs) are a large family of proteins involved in the recognition and discrimination of numerous odorants. These receptors belong to the…”
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