The various therapeutic applications of the medical isotope holmium-166: a narrative review

The various therapeutic applications of the medical isotope holmium-166: a narrative review

Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which can be used for a therapeutic effect and gamma radiation which can be used for nuclear imagin...

Full description

Saved in:
Bibliographic Details
Published in:EJNMMI radiopharmacy and chemistry Vol. 4; no. 1; p. 19
Main Authors: Klaassen, Nienke J. M., Arntz, Mark J., Gil Arranja, Alexandra, Roosen, Joey, Nijsen, J. Frank W.
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 05-08-2019
Springer Nature B.V
SpringerOpen
Subjects:
Acids
Cancer therapies
Chemistry
Chitosan
Drug dosages
Hepatocellular carcinoma
Holmium
Holmium-166
Imaging
Lanthanide
Liver
Malignancy
Medical equipment
Medicine
Medicine & Public Health
Metastases
Microspheres
Molecular Medicine
Neutrons
Nuclear Chemistry
Nuclear Medicine
Nuclear reactors
Patients
Pharmacotherapy
Radiation therapy
Radiology
Review
SIRT
Skin cancer
Therapeutic applications
β Radiation
γ Radiation
Microspheres
Lanthanide
Holmium
Radiation therapy
Chitosan
Holmium-166
SIRT
DOTMP
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which can be used for a therapeutic effect and gamma radiation which can be used for nuclear imaging purposes. Furthermore, holmium-165 can be visualized by MRI because of its paramagnetic properties and by CT because of its high density. Since holmium-165 has a natural abundance of 100%, the only by-product is metastable holmium-166 and no costly chemical purification steps are necessary for production of nuclear reactor derived holmium-166. Several compounds labelled with holmium-166 are now used in patients, such Ho 166 -labelled microspheres for liver malignancies, Ho 166 -labelled chitosan for hepatocellular carcinoma (HCC) and [ 166 Ho]Ho DOTMP for bone metastases. The outcomes in patients are very promising, making this isotope more and more interesting for applications in interventional oncology. Both drugs as well as medical devices labelled with radioactive holmium are used for internal radiotherapy. One of the treatment possibilities is direct intratumoural treatment, in which the radioactive compound is injected with a needle directly into the tumour. Numerous other applications have been developed, like patches for treatment of skin cancer and holmium labelled antibodies and peptides. The second major application that is currently clinically applied is selective internal radiation therapy (SIRT, also called radioembolization), a novel treatment option for liver malignancies. This review discusses medical drugs and medical devices based on the therapeutic radionuclide holmium-166.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2365-421X
2365-421X
DOI:10.1186/s41181-019-0066-3