Search Results - "Gil, D W"

Role of sympathetic nervous system in rat model of chronic visceral pain by Gil, D. W., Wang, J., Gu, C., Donello, J. E., Cabrera, S., Al‐Chaer, E. D.

“…Background Changes in central pain modulation have been implicated in generalized pain syndromes such as irritable bowel syndrome (IBS). We have previously…”
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Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024) by Woodward, D F, Krauss, A H-P, Chen, J, Liang, Y, Li, C, Protzman, C E, Bogardus, A, Chen, R, Kedzie, K M, Krauss, H A, Gil, D W, Kharlamb, A, Wheeler, L A, Babusis, D, Welty, D, Tang-Liu, D D-S, Cherukury, M, Andrews, S W, Burk, R M, Garst, M E

“…Replacement of the carboxylic acid group of prostaglandin (PG) F(2alpha) with a nonacidic moiety, such as hydroxyl, methoxy, or amido, results in compounds…”
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Transient allodynia pain models in mice for early assessment of analgesic activity by Gil, D W, Cheevers, C V, Donello, J E

“…Background and purpose: The most common preclinical models of neuropathic pain involve surgical ligation of sensory nerves, which is especially difficult in…”
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Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype by Regan, J W, Bailey, T J, Pepperl, D J, Pierce, K L, Bogardus, A M, Donello, J E, Fairbairn, C E, Kedzie, K M, Woodward, D F, Gil, D W

“…A cDNA that when expressed has the binding and functional characteristics of the pharmacologically defined EP2 prostaglandin (PG) receptor [Cardiovasc. Drug…”
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The Pharmacology of Bimatoprost (Lumigan™) by Woodward, D.F, Krauss, A.H.-P, Chen, J, Lai, R.K, Spada, C.S, Burk, R.M, Andrews, S.W, Shi, L, Liang, Y, Kedzie, K.M, Chen, R, Gil, D.W, Kharlamb, A, Archeampong, A, Ling, J, Madhu, C, Ni, J, Rix, P, Usansky, J, Usansky, H, Weber, A, Welty, D, Yang, W, Tang-Liu, D.D.-S, Garst, M.E, Brar, B, Wheeler, L.A, Kaplan, L.J

“…Bimatoprost (Lumigan™) is a pharmacologically unique and highly efficacious ocular hypotensive agent. It appears to mimic the activity of a newly discovered…”
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Muscarinic receptor subtypes in human iris-ciliary body measured by immunoprecipitation by Gil, DW, Krauss, HA, Bogardus, AM, WoldeMussie, E

“…To determine the relative levels of the five muscarinic receptor subtypes in the anterior segment of the human eye. Antisera selective for each of the five…”
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Pirenzepine distinguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase by Gil, D W, Wolfe, B B

“…Subtypes of muscarinic cholinergic receptors have been proposed to exist, but the biochemical responses mediated by the putative subtypes are unknown. In the…”
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Replacement of the carboxylic acid group of prostaglandin F2α with a hydroxyl or methoxy substituent provides biologically unique compounds by Woodward, D F, Krauss, A H‐P, Chen, J, Gil, D W, Kedzie, K M, Protzman, C E, Shi, L, Chen, R, Krauss, H A, Bogardus, A, Dinh, H T T, Wheeler, L A, Andrews, S W, Burk, R M, Gac, T, Roof, M B, Garst, M E, Kaplan, L J, Sachs, G, Pierce, K L, Regan, J W, Ross, R A, Chan, M F

“…Replacement of the carboxylic acid group of PGF2α with the non‐acidic substituents hydroxyl (‐OH) or methoxy (‐OCH3) resulted in an unexpected activity…”
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Cloning of a receptor for prostaglandin F2 alpha from the ovine corpus luteum by Graves, P E, Pierce, K L, Bailey, T J, Rueda, B R, Gil, D W, Woodward, D F, Yool, A J, Hoyer, P B, Regan, J W

“…A complementary DNA clone encoding a functional receptor for prostaglandin F2 alpha (PGF2 alpha) has been isolated from an ovine large luteal cell…”
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Cytogenetic and molecular localization of tipE: a gene affecting sodium channels in Drosophila melanogaster by Feng, G.P. (Washington University School of Medicine, St. Louis, MO.), Deak, P, Kasbekar, D.P, Gil, D.W, Hall, L.M

“…Voltage-sensitive sodium channels play a key role in nerve cells where they are responsible for the increase in sodium permeability during the rising phase of…”
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Cloning of human prostanoid receptors by Pierce, Kristen L., Gil, Daniel W., Woodward, David F., Regan, John W.

“…Prostaglandins and thromboxanes are locally acting hormones derived from arachidonic acid by the actions of cyclooxygenases, and are responsible for a wide…”
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alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia by Donello, J E, Padillo, E U, Webster, M L, Wheeler, L A, Gil, D W

“…Recent studies have suggested that alpha(2)-adrenergic agonists prevent neuronal cell death in a number of animal models, although the mechanism of…”
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Role of Alpha-2 Adrenergic Receptors in Neuroprotection and Glaucoma by Wheeler, Larry A, Gil, Daniel W, WoldeMussie, Elizabeth

“…The loss of retinal ganglion cells (RGCs) in glaucoma occurs progressively over many years. A neuroprotective drug should enhance survival of RGCs in the…”
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Molecular characterization and ocular hypotensive properties of the prostanoid EP2 receptor by Woodward, D F, Bogardus, A M, Donello, J E, Fairbairn, C E, Gil, D W, Kedzie, K M, Burke, J A, Kharlamb, A, Runde, E, Andrews, S W

“…The cloning of the genes that encode for prostaglandin (PG) receptors has resolved much of the complexity and controversy in this area by confirming the…”
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Muscarinic cholinergic receptor binding sites differentiated by their affinity for pirenzepine do not interconvert by Gil, D W, Wolfe, B B

“…Although it has been suggested by many investigators that subtypes of muscarinic cholinergic receptors exist, physical studies of solubilized receptors have…”
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Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds by Woodward, D F, Krauss, A H, Chen, J, Gil, D W, Kedzie, K M, Protzman, C E, Shi, L, Chen, R, Krauss, H A, Bogardus, A, Dinh, H T, Wheeler, L A, Andrews, S W, Burk, R M, Gac, T, Roof, M B, Garst, M E, Kaplan, L J, Sachs, G, Pierce, K L, Regan, J W, Ross, R A, Chan, M F

“…Replacement of the carboxylic acid group of PGF(2alpha) with the non-acidic substituents hydroxyl (-OH) or methoxy (-OCH(3)) resulted in an unexpected activity…”
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Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini by Regan, J.W., Bailey, T.J., Donello, J.E., Pierce, K.L., Pepperl, D.J., Zhang, D., Kedzie, K.M., Fairbairn, C.E., Bogardus, A.M., Woodward, D.F., Gil, D.W.

“…1 The polymerase chain reaction (PCR) was used in combination with plaque hybridization analysis to clone four variants of the EP3 prostaglandin receptor from…”
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Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor by Pierce, K.L, Bailey, T.J, Hoyer, P.B, Gil, D.W, Woodward, D.F, Regan, J.W

“…An FP prostanoid receptor isoform, which appears to arise from alternative mRNA splicing, has been cloned from a mid-cycle ovine large cell corpus luteum…”
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DEVELOPMENT OF RAR SUBTYPE SELECTIVE RETINOIDS FOR DERMATOLOGICAL DISEASES by Chandraratna, Roshantha A.S., Henry, Elizabeth, Attard, John, Gillett, Samuel J., Song, Tae, Garst, Michael E., Nagpal, Sunil, Athanikar, Jyoti, Arefieg, Taghreed, Gil, Daniel W., Wheeler, Larry A., Lew-Kaya, Deborah, Sefton, John

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A single amino-acid substitution in the EP2 prostaglandin receptor confers responsiveness to prostacyclin analogs by Kedzie, K M, Donello, J E, Krauss, H A, Regan, J W, Gil, D W

“…A high degree of homology between the four Gs-coupled prostaglandin (PG) receptors [EP2, EP4, prostacyclin (IP), PGD2 (DP)] and the four Gq/Gi-coupled…”
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