Search Results - "Gijsen, Matthias"

Software Tools for Model-Informed Precision Dosing: How Well Do They Satisfy the Needs? by Kantasiripitak, Wannee, Van Daele, Ruth, Gijsen, Matthias, Ferrante, Marc, Spriet, Isabel, Dreesen, Erwin

“…Model-informed precision dosing (MIPD) software tools are used to optimize dosage regimens in individual patients, aiming to achieve drug exposure targets…”
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Can augmented renal clearance be detected using estimators of glomerular filtration rate? by Gijsen, Matthias, Wilmer, Alexander, Meyfroidt, Geert, Wauters, Joost, Spriet, Isabel

“…Estimators of glomerular filtration rate (GFR) have been shown to be flawed in critically ill patients, especially for augmented renal clearance (ARC),…”
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Editorial for the Special Issue: “Therapeutic Drug Monitoring of Antimicrobials” by Gijsen, Matthias, Allegaert, Karel

“…A recent guideline [...]…”
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Pharmacokinetics of Antibiotics in Pediatric Intensive Care: Fostering Variability to Attain Precision Medicine by Gijsen, Matthias, Vlasselaers, Dirk, Spriet, Isabel, Allegaert, Karel

“…Children show important developmental and maturational changes, which may contribute greatly to pharmacokinetic (PK) variability observed in pediatric…”
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Meropenem Pharmacokinetics and Target Attainment in Critically Ill Patients Are Not Affected by Extracorporeal Membrane Oxygenation: A Matched Cohort Analysis by Gijsen, Matthias, Dreesen, Erwin, Annaert, Pieter, Nicolai, Johan, Debaveye, Yves, Wauters, Joost, Spriet, Isabel

“…Existing evidence is inconclusive whether meropenem dosing should be adjusted in patients receiving extracorporeal membrane oxygenation (ECMO). Therefore, the…”
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Isavuconazole Exposure in Critically Ill Patients Treated with Extracorporeal Membrane Oxygenation: Two Case Reports and a Narrative Literature Review by Mertens, Beatrijs, Elkayal, Omar, Dreesen, Erwin, Wauters, Joost, Meersseman, Philippe, Debaveye, Yves, Degezelle, Karlien, Vermeersch, Pieter, Gijsen, Matthias, Spriet, Isabel

“…Effective dosing of isavuconazole in patients supported by extracorporeal membrane oxygenation (ECMO) is important due to the role of isavuconazole as a…”
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Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial Therapy by Van den Broucke, Evelyne, Thijs, Lore, Desmet, Stefanie, Vander Elst, Lotte, Gijsen, Matthias, Mylemans, Marnix, Van de Gaer, Otto, Peetermans, Willy E, Quintens, Charlotte, Spriet, Isabel

“…In 2020, EUCAST introduced breakpoints for temocillin. Based on these guidelines, reporting of temocillin susceptibility of Enterobacterales in the context of…”
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Pharmacokinetic/Pharmacodynamic Target Attainment Based on Measured versus Predicted Unbound Ceftriaxone Concentrations in Critically Ill Patients with Pneumonia: An Observational Cohort Study by Gijsen, Matthias, Dreesen, Erwin, Van Daele, Ruth, Annaert, Pieter, Debaveye, Yves, Wauters, Joost, Spriet, Isabel

“…The impact of ceftriaxone pharmacokinetic alterations on protein binding and PK/PD target attainment still remains unclear. We evaluated…”
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Systematic Comparison of Hospital-Wide Standard and Model-Based Therapeutic Drug Monitoring of Vancomycin in Adults by Gastmans, Heleen, Dreesen, Erwin, Wicha, Sebastian G, Dia, Nada, Spreuwers, Ellen, Dompas, Annabel, Allegaert, Karel, Desmet, Stefanie, Lagrou, Katrien, Peetermans, Willy E, Debaveye, Yves, Spriet, Isabel, Gijsen, Matthias

“…We aimed to evaluate the predictive performance and predicted doses of a single-model approach or several multi-model approaches compared with the standard…”
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Meropenem Stability in Human Plasma at -20 °C: Detailed Assessment of Degradation by Gijsen, Matthias, Filtjens, Benjamin, Annaert, Pieter, Armoudjian, Yeghig, Debaveye, Yves, Wauters, Joost, Slaets, Peter, Spriet, Isabel

“…There are concerns about the stability of meropenem in plasma samples, even when frozen at -20 °C. Previous smaller studies suggested significant degradation…”
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External Validation of the Augmented Renal Clearance Predictor in Critically Ill COVID-19 Patients by Huang, Chao-Yuan, Güiza, Fabian, Gijsen, Matthias, Spriet, Isabel, Dauwe, Dieter, Debaveye, Yves, Peetermans, Marijke, Wauters, Joost, Van den Berghe, Greet, Meyfroidt, Geert, De Vlieger, Greet

“…The ARC predictor is a prediction model for augmented renal clearance (ARC) on the next intensive care unit (ICU) day that showed good performance in a general…”
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Reproducibility of fluid status measured by bioelectrical impedance analysis in healthy volunteers: a key requirement to monitor fluid status in the intensive care unit by Gijsen, Matthias, Simons, Eline, De Cock, Pieter, L N G Malbrain, Manu, Wauters, Joost, Spriet, Isabel

“…Little is known about the use of bioelectrical impedance analysis (BIA) in critically ill patients. The objective of this study was to evaluate the…”
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Pharmacokinetic Variability and Target Attainment of Fluconazole in Critically Ill Patients by Van Daele, Ruth, Wauters, Joost, Lagrou, Katrien, Denooz, Raphaël, Hayette, Marie-Pierre, Gijsen, Matthias, Brüggemann, Roger J., Debaveye, Yves, Spriet, Isabel

“…Background: Fluconazole is one of the oldest antifungal drugs. Previous studies have raised concerns considering variability in exposure and inadequate target…”
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Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid by Van Daele, Ruth, Wauters, Joost, De Cock, Pieter, Buyle, Franky, Leys, John, Van Brantegem, Pieter, Gijsen, Matthias, Annaert, Pieter, Debaveye, Yves, Lagrou, Katrien, Peetermans, Willy E., Brüggemann, Roger J., Spriet, Isabel

“…Background: Voriconazole is an antifungal drug used as one of the first-line treatments for invasive aspergillosis. This drug is extensively metabolized,…”
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Predicting Beta-Lactam Target Non-Attainment in ICU Patients at Treatment Initiation: Development and External Validation of Three Novel (Machine Learning) Models by Wieringa, André, Ewoldt, Tim M J, Gangapersad, Ravish N, Gijsen, Matthias, Parolya, Nestor, Kats, Chantal J A R, Spriet, Isabel, Endeman, Henrik, Haringman, Jasper J, van Hest, Reinier M, Koch, Birgit C P, Abdulla, Alan

“…In the intensive care unit (ICU), infection-related mortality is high. Although adequate antibiotic treatment is essential in infections, beta-lactam target…”
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Oral antimicrobial agents in patients with short bowel syndrome: the importance of considering TDM by Deleenheer, Barbara, Gijsen, Matthias, Spriet, Isabel, Vanuytsel, Tim

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The TARGET trial as a plea for model-informed precision dosing of piperacillin/tazobactam in patients with sepsis by Gijsen, Matthias, Dreesen, Erwin, Wauters, Joost, Debaveye, Yves, Spriet, Isabel

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A good start is half the battle: Antibiotic IV line residuals in the intensive care unit by Vanneste, Dorian, Gijsen, Matthias, Debaveye, Yves, Wauters, Joost, Spriet, Isabel

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Ceftriaxone dosing based on the predicted probability of augmented renal clearance in critically ill patients with pneumonia by Dreesen, Erwin, Gijsen, Matthias, Elkayal, Omar, Annaert, Pieter, Debaveye, Yves, Wauters, Joost, Karlsson, Mats O, Spriet, Isabel

“…Abstract Objectives PTA of protein-unbound ceftriaxone may be compromised in critically ill patients with community-acquired pneumonia (CAP) with augmented…”
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Ceftazidime-related neurotoxicity in a patient with renal impairment: a case report and literature review by Vanneste, Dorian, Gijsen, Matthias, Maertens, Johan, Van Paesschen, Wim, Debaveye, Yves, Wauters, Joost, Spriet, Isabel

“…Purpose We present the case of a 67-year-old woman with severely reduced renal clearance suffering from ceftazidime-induced encephalopathy. Subsequently, we…”
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