Search Results - "Gijsbers, Abril"

Cryo-EM structures from sub-nl volumes using pin-printing and jet vitrification by Ravelli, Raimond B. G., Nijpels, Frank J. T., Henderikx, Rene J. M., Weissenberger, Giulia, Thewessem, Sanne, Gijsbers, Abril, Beulen, Bart W. A. M. M., López-Iglesias, Carmen, Peters, Peter J.

“…The increasing demand for cryo-electron microscopy (cryo-EM) reveals drawbacks in current sample preparation protocols, such as sample waste and lack of…”
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Guanine nucleotide exchange in the ribosomal GTPase EFL1 is modulated by the protein mutated in the Shwachman–Diamond Syndrome by Gijsbers, Abril, García-Márquez, Adrián, Luviano, Axel, Sánchez-Puig, Nuria

“…•The SBDS proteins act as nucleotide exchange factors for the ribosomal EFL1 GTPases.•The SBDS proteins decreases twofold the Km values of the EFL1 GTPases for…”
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Interaction of the GTPase Elongation Factor Like-1 with the Shwachman-Diamond Syndrome Protein and Its Missense Mutations by Gijsbers, Abril, Montagut, Diana Carolina, Méndez-Godoy, Alfonso, Altamura, Davide, Saviano, Michele, Siliqi, Dritan, Sánchez-Puig, Nuria

“…The Shwachman-Diamond Syndrome (SDS) is a disorder arising from mutations in the genes encoding for the Shwachman-Bodian-Diamond Syndrome (SBDS) protein and…”
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Single nucleotide variation catalog from clinical isolates mapped on tertiary and quaternary structures of ESX-1-related proteins reveals critical regions as putative Mtb therapeutic targets by Tzfadia, Oren, Gijsbers, Abril, Vujkovic, Alexandra, Snobre, Jihad, Vargas, Roger, Dewaele, Klaas, Meehan, Conor J, Farhat, Maha, Hakke, Sneha, Peters, Peter J, de Jong, Bouke C, Siroy, Axel, Ravelli, Raimond B G

“…Proteins encoded by the ESX-1 genes of interest are essential for full virulence in all complex (Mtbc) lineages, the pathogens causing the highest mortality…”
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Structural Analysis of the Partially Disordered Protein EspK from Mycobacterium Tuberculosis by Gijsbers, Abril, Sánchez-Puig, Nuria, Gao, Ye, Peters, Peter J., Ravelli, Raimond B. G., Siliqi, Dritan

“…For centuries, tuberculosis has been a worldwide burden for human health, and gaps in our understanding of its pathogenesis have hampered the development of…”
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Physical association of low density lipoprotein particles and extracellular vesicles unveiled by single particle analysis by Lozano‐Andrés, Estefanía, Enciso‐Martinez, Agustin, Gijsbers, Abril, Ridolfi, Andrea, Van Niel, Guillaume, Libregts, Sten F. W. M., Pinheiro, Cláudio, Herwijnen, Martijn J. C., Hendrix, An, Brucale, Marco, Valle, Francesco, Peters, Peter J., Otto, Cees, Arkesteijn, Ger J. A., Wauben, Marca H. M.

“…Extracellular vesicles (EVs) in blood plasma are recognized as potential biomarkers for disease. Although blood plasma is easily obtainable, analysis of EVs at…”
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Priming mycobacterial ESX-secreted protein B to form a channel-like structure by Gijsbers, Abril, Vinciauskaite, Vanesa, Siroy, Axel, Gao, Ye, Tria, Giancarlo, Mathew, Anjusha, Sánchez-Puig, Nuria, López-Iglesias, Carmen, Peters, Peter J., Ravelli, Raimond B.G.

“…ESX-1 is a major virulence factor of Mycobacterium tuberculosis, a secretion machinery directly involved in the survival of the microorganism from the immune…”
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Fluorescence Anisotropy as a Tool to Study Protein-protein Interactions by Gijsbers, Abril, Nishigaki, Takuya, Sánchez-Puig, Nuria

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Fluorescence Anisotropy as a Tool to Study Protein-protein Interactions by Gijsbers, Abril, Nishigaki, Takuya, Sánchez-Puig, Nuria

“…Protein-protein interactions play an essential role in the function of a living organism. Once an interaction has been identified and validated it is necessary…”
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The crystal structure of the EspB-EspK virulence factor-chaperone complex suggests an additional type VII secretion mechanism in Mycobacterium tuberculosis by Gijsbers, Abril, Eymery, Mathias, Gao, Ye, Menart, Isabella, Vinciauskaite, Vanesa, Siliqi, Dritan, Peters, Peter J., McCarthy, Andrew, Ravelli, Raimond B.G.

“…Pathogenic species from the Mycobacterium genus are responsible for a number of adverse health conditions in humans and animals that threaten health security…”
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Mycobacterium tuberculosis ferritin: a suitable workhorse protein for cryo‐EM development by Gijsbers, Abril, Zhang, Yue, Gao, Ye, Peters, Peter J., Ravelli, Raimond B. G.

“…The use of cryo‐EM continues to expand worldwide and calls for good‐quality standard proteins with simple protocols for their production. Here, a…”
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Defective Guanine Nucleotide Exchange in the Elongation Factor-like 1 (EFL1) GTPase by Mutations in the Shwachman-Diamond Syndrome Protein by García-Márquez, Adrián, Gijsbers, Abril, de la Mora, Eugenio, Sánchez-Puig, Nuria

“…Ribosome biogenesis is orchestrated by the action of several accessory factors that provide time and directionality to the process. One such accessory factor…”
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Fluorescence Anisotropy as a Tool to Study Protein-protein Interactions by Gijsbers, Abril, Nishigaki, Takuya, Sánchez-Puig, Nuria

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Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics by Delre, Pietro, Alberga, Domenico, Gijsbers, Abril, Sánchez-Puig, Nuria, Nicolotti, Orazio, Saviano, Michele, Siliqi, Dritan, Mangiatordi, Giuseppe Felice

“…Shwachman-Diamond Syndrome (SDS) is an autosomal recessive disorder whose patients present mutations in two ribosome assembly proteins, the…”
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Inside structure of the EFL1, SBDS and their complex by Siliqi, Dritan, Sanchez-Puig, Nuria, Altamura, Davide, Gijsbers, Abril, Méndez-Godoy, Alfonso, Giannini, Cinzia, Saviano, Michele

“…Abstract only…”
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Mutations in EFL1 , an SBDS partner, are associated with infantile pancytopenia, exocrine pancreatic insufficiency and skeletal anomalies in aShwachman-Diamond like syndrome by Stepensky, Polina, Chacón-Flores, Montserrat, Kim, Katherine H, Abuzaitoun, Omar, Bautista-Santos, Arnulfo, Simanovsky, Natalia, Siliqi, Dritan, Altamura, Davide, Méndez-Godoy, Alfonso, Gijsbers, Abril, Naser Eddin, Adeeb, Dor, Talia, Charrow, Joel, Sánchez-Puig, Nuria, Elpeleg, Orly

“…For the final step of the maturation of the ribosome, the nascent 40S and 60S subunits are exported from the nucleus to the cell cytoplasm. To prevent…”
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Small-angle X-ray scattering (SAXS) studies of the low-resolution structure of the ribosomal GTPase EFL1, the SBDS protein and their complex by Siliqi, Dritan, Altamura, Davide, Gijsbers, Abril, de la Mora, Eugenio, Giannini, Cinzia, Sibillano, Teresa, Saviano, Michele, Sanchez-Puig, Nuria

“…Abstract only…”
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