Search Results - "Gijbels, M. J. M."

Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice by van den Berg, S M, Seijkens, T T P, Kusters, P J H, Zarzycka, B, Beckers, L, den Toom, M, Gijbels, M J J, Chatzigeorgiou, A, Weber, C, de Winther, M P J, Chavakis, T, Nicolaes, G A F, Lutgens, E

“…Background: Immune processes contribute to the development of obesity and its complications, such as insulin resistance, type 2 diabetes mellitus and…”
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Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model by Schreinemacher, M. H. F., Emans, P. J., Gijbels, M. J. J., Greve, J.-W. M., Beets, G. L., Bouvy, N. D.

“…Background: In laparoscopic ventral hernia repair a mesh is placed in direct contact with the viscera, often leading to substantial adhesions. In this…”
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Comparison of three different application routes of butyrate to improve colonic anastomotic strength in rats by Bosmans, J. W. A. M., Jongen, A. C. H. M., Boonen, B. T. C., van Rijn, S., Scognamiglio, F., Stucchi, L., Gijbels, M. J. J., Marsich, E., Bouvy, N. D.

“…Introduction Despite extensive research, anastomotic leakage (AL) remains one of the most dreaded complications after colorectal surgery. Since butyrate enemas…”
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Long-term evaluation of adhesion formation and foreign body response to three new meshes by Vogels, R. R. M., van Barneveld, K. W. Y., Bosmans, J. W. A. M., Beets, G., Gijbels, M. J. J., Schreinemacher, M. H. F., Bouvy, N. D.

“…Introduction Mesh-related adhesions are a significant clinical problem following intraperitoneal mesh placement. In this study, we evaluated adhesion formation…”
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Adhesions to sutures, tackers, and glue for intraperitoneal mesh fixation: an experimental study by Schreinemacher, M. H. F., van Barneveld, K. W. Y., Peeters, E., Miserez, M., Gijbels, M. J. J., Greve, J.-W. M., Bouvy, N. D.

“…Purpose Intraperitoneal mesh fixation for hernia repair is associated with adhesion formation. In this experimental study, adhesions against absorbable and…”
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Functional mucous layer and healing of proximal colonic anastomoses in an experimental model by Bosmans, J. W. A. M., Jongen, A. C. H. M., Birchenough, G. M. H., Nyström, E. E. L., Gijbels, M. J. J., Derikx, J. P. M., Bouvy, N. D., Hansson, G. C.

“…Background Anastomotic leakage (AL) is the most dreaded complication after colorectal surgery, causing high morbidity and mortality. Mucus is a first line of…”
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Disruption of hedgehog signalling in ApoE − /− mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages by Beckers, L, Heeneman, S, Wang, L, Burkly, LC, Rousch, MMJ, Davidson, NO, Gijbels, MJJ, de Winther, MPJ, Daemen, MJAP, Lutgens, E

“…Embryonic pathways are often re‐expressed in adult pathology. Here we investigated the role of the morphogen hedgehog (hh), which we found to be re‐expressed…”
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Keratinocyte growth factor ameliorates acute graft-versus-host disease in a novel nonmyeloablative haploidentical transplantation model by VANCLEE, A, LUTGENS, L. C. H. W, OVING, E. B. H, DEUTZ, N. E. P, GIJBELS, M. J. J, SCHOUTEN, H. C, BOS, G. M. J

“…Allogeneic stem cell transplantations (SCT) are currently being used as a therapy for hematological malignancies, some solid tumors and nonmalignant bone…”
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Prevention of incisional hernia using different suture materials for closing the abdominal wall: a comparison of PDS, Vicryl and Prolene in a rat model by van Steensel, S., van den Hil, L. C. L., Bloemen, A., Gijbels, M. J., Breukink, S. O., Melenhorst, J., Lenaerts, K., Bouvy, N. D.

“…Purpose An incisional hernia occurs frequently after a midline incision with an incidence of 12.8%. The choice in suture material used for abdominal wall…”
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A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice by HogenEsch, H, Gijbels, MJ, Offerman, E, van Hooft, J, van Bekkum, DW, Zurcher, C

“…Chronic proliferative dermatitis is a new spontaneous mutation in C57BL/Ka mice. Breeding results suggest an autosomal recessive mode of inheritance. Mutant…”
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NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons by Vaes, N., Lentjes, M. H. F. M., Gijbels, M. J., Rademakers, G., Daenen, K. L., Boesmans, W., Wouters, K. A. D., Geuzens, A., Qu, X., Steinbusch, H. P. J., Rutten, B. P. F., Baldwin, S. H., Sharkey, K. A., Hofstra, R. M. W., Engeland, M., Vanden Berghe, P., Melotte, V.

“…Background Promoter methylation of N‐myc Downstream‐Regulated Gene 4 (NDRG4) in fecal DNA is an established early detection marker for colorectal cancer (CRC)…”
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Overexpression of fibrinogen in ApoE3-Leiden transgenic mice does not influence the progression of diet-induced atherosclerosis by Rezaee, F, Gijbels, M J, Offerman, E H, van der Linden, M, De Maat, M P M, Verheijen, J H

“…Although many epidemiological studies have shown an association between hyperfibrinogenemia and atherosclerosis, it is not established whether elevated…”
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Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm) by Gijbels, MJ, Zurcher, C, Kraal, G, Elliott, GR, HogenEsch, H, Schijff, G, Savelkoul, HF, Bruijnzeel, PL

“…Chronic proliferative dermatitis is a spontaneous mutation in C57BL/Ka mice (cpdm/cpdm), showing alopecia, epithelial hyperproliferation, infiltration by…”
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Therapeutic interventions in mice with chronic proliferative dermatitis (cpdm/cpdm) by Gijbels, M. J. J., Elliott, G. R., HogenEsch, H., Zurcher, C., Van Den Hoven, A., Bruijnzeel, P. L. B.

“…: Chronic proliferative dermatitis (cpd) is a spontaneous mutation in C57BL/Ka mice ( cpdm/cpdm). The dermatitis is characterized by redness, hairloss,…”
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Disruption of the Cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation by LUTGENS, E, LUTGENS, S. P. M, FISHER, A, LONG, C. J, SAFTIG, P, BLACK, D, DAEMEN, M. J. A. P, CLEUTJENS, K. B. J. M, FABER, B. C. G, HEENEMAN, S, GIJBELS, M. M. J, DE WINTHER, M. P. J, FREDERIK, P, VAN DER MADE, I, DAUGHERTY, A, SIJBERS, A. M

“…Cathepsin K (catK), a lysosomal cysteine protease, was identified in a gene-profiling experiment that compared human early plaques, advanced stable plaques,…”
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Leukocyte CD40L deficiency affects the CD25 + CD4 T cell population but does not affect atherosclerosis by Smook, M.L.F., Heeringa, P., Damoiseaux, J.G.M.C., Daemen, M.J.A.P., de Winther, M.P.J., Gijbels, M.J.J., Beckers, L., Lutgens, E., Cohen Tervaert, J.W.

“…Inhibition of CD40–CD40L interactions results in a reduction of innate regulatory T cells (Tregs) in CD40 −/− mice and induces a stable plaque phenotype in…”
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Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice by VAN VLIJMEN, B. J. M, VAN DEN MAAGDENBERG, A. M. J. M, GIJBELS, M. J. J, VAN DER BOOM, H, HOGENESCH, H, FRANTS, R. R, HOFKER, M. H, HAVEKES, L. M

“…Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been used to study the effect of different cholesterol-containing diets on the remnant…”
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Macrophage p53 Deficiency Leads to Enhanced Atherosclerosis in APOE3-Leiden Transgenic Mice by van Vlijmen, Bart J.M, Gerritsen, Gery, Franken, Arthur L, Boesten, Lianne S.M, Kockx, Mark M, Gijbels, Marion J, Vierboom, Michel P, van Eck, Miranda, van deWater, Bob, van Berkel, Theo J.C, Havekes, Louis M

“…ABSTRACT—Cell proliferation and cell death (either necrosis or apoptosis) are key processes in the progression of atherosclerosis. The tumor suppressor gene…”
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Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice by de Winther, Menno P.J., Gijbels, Marion J.J., van Dijk, Ko Willems, van Gorp, Patrick J.J., Suzuki, Hiroshi, Kodama, Tatsuhiko, Frants, Rune R., Havekes, Louis M., Hofker, Marten H.

“…Apolipoprotein (apo) E3Leiden is a dysfunctional apo E variant associated with familial dysbetalipoproteinemia in humans. Transgenic mice carrying the…”
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Alterations in cytokeratin expression precede histological changes in epithelia of vitamin A-deficient rats by GIJBELS, M. J. J, VAN DER HAM, F, VAN BENNEKUM, A. M, HENDRIKS, H. F. J, ROHOLL, P. J. M

“…Normal epithelial cell differentiation is characterized by the production of distinct cytokeratin proteins. It is well known that epithelia of several organs…”
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