Search Results - "Giger, Rudolf"
-
1
The Serotonin 5-HT4 Receptor. 2. Structure-Activity Studies of the Indole Carbazimidamide Class of Agonists
Published in Journal of medicinal chemistry (01-06-1995)“…A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT4 receptor agonists by using the isolated field-stimulated guinea pig ileum…”
Get full text
Journal Article -
2
From Solution-Phase Studies to Solid-Phase Synthesis: A New Indole Based Scaffold for Combinatorial Chemistry
Published in Chimia (01-05-2003)“…The core structure of a natural product was selected as scaffold for combinatorial library synthesis. The key step for the construction of the…”
Get full text
Journal Article -
3
Albert Hofmann's Pioneering Work on Ergot Alkaloids and Its Impact on the Search of Novel Drugs at Sandoz, a Predecessor Company of Novartis: Dedicated to Dr. Albert Hofmann on the occasion of his 100th birthday
Published in Chimia (23-02-2006)“…The scientific research on ergot alkaloids is fundamentally related to the work of Dr. Albert Hofmann, who was able to produce, from 1935 onwards, a number of…”
Get full text
Journal Article -
4
The Serotonin 5-HT4 Receptor. 1. Design of a New Class of Agonists and Receptor Map of the Agonist Recognition Site
Published in Journal of medicinal chemistry (01-06-1995)“…The design and synthesis of a new class of potent and selective 5-HT4 receptor agonists containing an indole nucleus linked to a carbazimidamide are presented…”
Get full text
Journal Article -
5
Synthesis of potential drug metabolites by a modified Udenfriend reaction
Published in Tetrahedron letters (16-02-2011)“…The scope and the limitations of a modified Udenfriend reaction for the one-step synthesis of potential drug metabolites were explored. Several drugs…”
Get full text
Journal Article -
6
Stereoselective Transformation of Indole Diazabicyclo[3.2.2]nonedione to Azepinoindole
Published in Organic letters (26-12-2002)“…The synthesis of an indole diazabicyclo[3.2.2]nonedione derivative was achieved in a few steps starting from l-tryptophan. Reduction with borane−THF complex…”
Get full text
Journal Article -
7
High-Throughput Analysis, Purification, and Quantification of Combinatorial Libraries of Single Compounds
Published in Chimia (01-01-2000)Get full text
Journal Article -
8
Studies on the total synthesis of steroidal antibiotics. 2. Two convergent schemes for the synthesis of tetracyclic intermediates
Published in Journal of organic chemistry (01-04-1977)Get full text
Journal Article -
9
Combinatorial Chemistry at Lead Finding
Published in Chimia (01-11-1997)Get full text
Journal Article -
10
Combinatorial Chemistry at Lead Finding
Published in Chimia (01-11-1997)Get full text
Journal Article -
11
Chapter 13 Case History on Tegaserod (Zelnorm®/Zelmac®)
Published in Annual Reports in Medicinal Chemistry (2007)“…Tegaserod (HTF919; Zelnorm®/Zelmac®) is an innovative and potent partial agonist at 5-HT4 receptors, which mediate multiple physiological functions in the…”
Get full text
Book Chapter
-
12
The Interdisciplinary Task of Medicinal Chemists
Published in Chimia (01-10-1995)Get full text
Journal Article -
13
The Interdisciplinary Task of Medicinal Chemists
Published in Chimia (01-10-1995)Get full text
Journal Article -
14
The Section for Medicinal Chemistry (SMC) of the New Swiss Chemical Society (NSCS)
Published in Chimia (01-11-1997)Get full text
Journal Article -
15
The Section for Medicinal Chemistry (SMC) of the New Swiss Chemical Society (NSCS)
Published in Chimia (01-11-1997)Get full text
Journal Article -
16