Search Results - "Gifford, Jessica L"

Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs by Gifford, Jessica L, Walsh, Michael P, Vogel, Hans J

“…The 'EF-hand' Ca2+-binding motif plays an essential role in eukaryotic cellular signalling, and the proteins containing this motif constitute a large and…”
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Altered mechanical properties of titin immunoglobulin domain 27 in the presence of calcium by DuVall, Michael M., Gifford, Jessica L., Amrein, Matthias, Herzog, Walter

“…Titin (connectin) based passive force regulation has been an important physiological mechanism to adjust to varying muscle stretch conditions. Upon stretch,…”
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Stabilizing specimens for routine ammonia testing in the clinical laboratory by Gifford, Jessica L., Nguyen, William N.T., de Koning, Lawrence, Seiden-Long, Isolde

“…In vitro deamination generates ammonia in freshly collected blood specimens. To prevent this, samples for ammonia testing are usually collected on ice and run…”
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Structural characterization of the interaction of human lactoferrin with calmodulin by Gifford, Jessica L, Ishida, Hiroaki, Vogel, Hans J

“…Lactoferrin (Lf) is an 80 kDa, iron (Fe(3+))-binding immunoregulatory glycoprotein secreted into most exocrine fluids, found in high concentrations in…”
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Fast methionine-based solution structure determination of calcium-calmodulin complexes by Gifford, Jessica L., Ishida, Hiroaki, Vogel, Hans J.

“…Here we present a novel NMR method for the structure determination of calcium-calmodulin (Ca 2+ -CaM)-peptide complexes from a limited set of experimental…”
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A high-throughput test for diabetes care: An evaluation of the next generation Roche Cobas c 513 hemoglobin A1C assay by Gifford, Jessica L., Higgins, Trefor, Sadrzadeh, S.M. Hossein

“…The level of glycated hemoglobin A (HbA1C) in blood is the preferred marker for diabetes monitoring and treatment. Here, we evaluate the analytical performance…”
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Filling in the GAPS: validation of anion gap (AGAP) measurement uncertainty estimates for use in clinical decision making by Gifford, Jessica L, Seiden-Long, Isolde

“…We compare measurement uncertainty (MU) calculations to real patient result variation observed by physicians using as our model anion gap (AGAP) sequentially…”
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Improving Equivalency in Metagenomics: A Harmonized Process to Extract Fecal DNA by Gifford, Jessica L

“…The impetus of harmonized results is expanding to the field of molecular pathology and is seen in the development of standardized reference materials for the…”
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Not T too! False elevations in high-sensitivity cardiac troponin T (hs-TnT) following specimen transport by Paul, Heather A., Chi, Qingli, Gifford, Jessica L., Seiden-Long, Isolde

“…Though false elevations attributed to preanalytical specimen handling have been widely reported for Troponin I (TnI), Troponin T (TnT) has appeared more robust…”
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Multidisciplinary approach to redefining thyroid hormone reference intervals with big data analysis by Lewis, Cody W., Raizman, Joshua E., Higgins, Victoria, Gifford, Jessica L., Symonds, Christopher, Kline, Gregory, Romney, Jacques, Doulla, Manpreet, Huang, Carol, Venner, Allison A.

“…•Big data analysis and multidisciplinary review to harmonize reference intervals for thyroid function tests.•Refinement of the TSH reflex algorithm to improve…”
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Strategies for mitigating risk posed by biotin interference on clinical immunoassays by Gifford, Jessica L., de Koning, Lawrence, Sadrzadeh, S. M. Hossein

“…Recently, biotin use as an oral supplement has increased significantly among the general population. Biotin is a water soluble B-vitamin and is marketed to…”
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Increased Lp(a) Workload Volumes Reflect Uptake of the 2021 Canadian Cardiovascular Society Guidelines for Management of Dyslipidemia by Orton, Dennis J., Gifford, Jessica L., Raizman, Joshua E., Pearson, Glen J., Tsui, Albert K.Y.

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Low partial pressure of oxygen causes significant and unrecognized under-recovery of glucose on blood gas analyzers by Wayne Lewis, Cody, Butorin, Yury, de Koning, Lawrence, Paul, Heather A., Gifford, Jessica L., Venner, Allison A., Seiden-Long, Isolde

“…Blood gas analyzers employing glucose-oxidase biosensors under-recover glucose when pO2 is low. The manufacturer of the GEM®Premier™ series of analyzers…”
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Structural Insights into Calmodulin-regulated L-selectin Ectodomain Shedding by Gifford, Jessica L., Ishida, Hiroaki, Vogel, Hans J.

“…The L-selectin glycoprotein receptor mediates the initial steps of leukocyte migration into secondary lymphoid organs and sites of inflammation. Following cell…”
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Critically High Plasma Ammonia in an Adolescent Girl by Orton, Dennis J, Gifford, Jessica L, Seiden-Long, Isolde, Khan, Aneal, de Koning, Lawrence

“…Common causes of hyperammonemia include liver failure (hepatocyte destruction and reduced urea cycle enzymes), drug reactions (e.g., inhibition of the urea…”
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Skeletal fluorosis in a resettled refugee from Kakuma refugee camp by Fabreau, Gabriel E, Bauman, Paul, Coakley, Annalee L, Johnston, Kelly, Kennel, Kurt A, Gifford, Jessica L, Sadrzadeh, Hossein MH, Whitford, Gary M, Whyte, Michael P, Kline, Gregory A

“…From 2009 to 2015, this patient had lived in the Kakuma refugee camp (Rift Valley Province, Kenya), which houses 184 966 inhabitants.2,3 He had chronic,…”
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Biotin interference: Underrecognized patient safety risk in laboratory testing by Gifford, Jessica L, Sadrzadeh, S M Hossein, Naugler, Christopher

“…Dietary supplementation with biotin is increasingly recognized as a patient safety risk, as it might lead to incorrect results for various common laboratory…”
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Comparing the Calcium Binding Abilities of Two Soybean Calmodulins: Towards Understanding the Divergent Nature of Plant Calmodulins by Gifford, Jessica L., Jamshidiha, Mostafa, Mo, Jeffrey, Ishida, Hiroaki, Vogel, Hans J.

“…The discovery that plants contain multiple calmodulin (CaM) isoforms of variable sequence identity to animal CaM suggested an additional level of…”
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Erroneous HbA1c results in a patient with elevated HbC and HbF by Adekanmbi, Joy, Higgins, Trefor, Rodriguez-Capote, Karina, Thomas, Dylan, Winterstein, Jeffrey, Dixon, Tara, Gifford, Jessica L., Krause, Richard, Venner, Allison A., Clarke, Gwen, Estey, Mathew P.

“…HbA1c is used in the diagnosis and monitoring of diabetes mellitus (DM). Interference from hemoglobin variants is a well-described phenomenon, particularly…”
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Structural analysis of a calmodulin variant from rice: the C-terminal extension of OsCaM61 regulates its calcium binding and enzyme activation properties by Jamshidiha, Mostafa, Ishida, Hiroaki, Sutherland, Cindy, Gifford, Jessica L, Walsh, Michael P, Vogel, Hans J

“…OsCaM61 is one of five calmodulins known to be present in Oryza sativa that relays the increase of cytosolic [Ca(2+)] to downstream targets. OsCaM61 bears a…”
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